Study Report
Reference
| Citation | MacMaster, 2008 PubMed |
| Full Info | MacMaster, F.P., Moore, G.J., Russell, A., Mirza, Y., Taormina, S.P., Buhagiar, C. and Rosenberg, D.R. (2008) Medial temporal N-acetyl-aspartate in pediatric major depression. Psychiatry Res, 164, 86-89.
|
Study
| Hypothesis or Background |
The medial temporal cortex (MTC) has been implicated in the pathogenesis of pediatric major depressive disorder (MDD).
|
| Sample Information | eleven MDD case-control pairs |
|---|
| Method Detail | Eleven MDD case-control pairs underwent proton magnetic resonance spectroscopic imaging. |
| Method Keywords | spectrophotometric analysis |
| Result | N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. |
| Conclusions | Lower N-acetyl-aspartate concentrations in MDD patients may reflect reduced neuronal viability. |
Relationships reported by
MacMaster, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
medial temporal regions (medial temporal cortex (MTC))
|
brain morphology and function |
N-acetylaspartate (N-acetyl-aspartate) |
molecule |
|
N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. |
Positive
|
|
MDD
|
syndrome |
medial temporal regions (medial temporal cortex (MTC)) |
brain morphology and function |
left MTC (27%) |
N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. |
Positive
|
|
MDD
|
syndrome |
N-acetylaspartate (N-acetyl-aspartate) |
molecule |
|
N-acetyl-aspartate was lower in the left MTC (27%) in MDD patients versus controls. |
Positive
|
