Cognition and Behavior Report

Basic Information

Name	Sensation
Description	Sensation is the process of receiving, converting, and transmitting raw sensory information from the external and internal environment to our brain. Sensation is the function of the low-level biochemical and neurological events that begin with the impinging of a stimulus upon the receptor cells of a sensory organ. In psychology, sensation and perception are stages of processing of the senses in human and animal systems, such as vision, auditory, vestibular, and pain senses.
No. of Studies (Positive/Negative)	9 (8/1)

Positive relationships betweenSensation and MDD (count: 5)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
functional deficits in auditory processing	Michael, 2004	patients and normal controls	P-value = 0.05	A subgroup of patients (n = 5) presented the following abnor...... A subgroup of patients (n = 5) presented the following abnormal habituation fMRI pattern: significantly lower activation after the first stimulation block (p = 0.05), missing characteristic signal decay to repeated acoustic stimulation and a marked undershoot after each stimulation block. This abnormal pattern may indicate functional deficits in auditory processing occurring with depression. More...
rapid visual information processing	Weiland-Fiedler, 2004	patients and normal controls		Patients with remitted MDD relative to controls were impaire...... Patients with remitted MDD relative to controls were impaired on tasks of rapid visual information processing (RVIP), psychomotor performance and spatial working memory (SWM). More...
early auditory processing is impaired	Kahkonen, 2007	patients and normal controls		Early auditory processing is impaired in patients with MDD d...... Early auditory processing is impaired in patients with MDD during an acute episode, probably reflecting dysfunctional frontotemporal neural circuits. More...
impaired ability to modulate pain experience	Strigo, 2008	patients and normal controls		These findings suggest that increased emotional reactivity d...... These findings suggest that increased emotional reactivity during the anticipation of heat pain may lead to an impaired ability to modulate pain experience in MDD More...
cold pressor pain sensitivity	Klatzkin, 2010	patients and normal controls		only in non-PMDD women was MDD associated with reduced cold ...... only in non-PMDD women was MDD associated with reduced cold pressor pain sensitivity More...

Positive relationships between Sensation and other level components at different levels (count: 4)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
abnormal sensory processing		N200(negative activity in the 157-210 ms section of the waveform)	neurobiological system	Pelosi, 2000	patients and normal controls	Surface negative activity in the 157-210 ms section of the w...... Surface negative activity in the 157-210 ms section of the waveform was reduced for all levels of memory load, suggesting abnormal sensory/perceptual processing in the modality-specific association cortices. More...
visual discrepancy		Alpha wave(slow-wave)	neurobiological system	Azuma, 2007	patients only	Postictal suppression and slow-wave amplitude correlated pos...... Postictal suppression and slow-wave amplitude correlated positively with delayed memory and visual/verbal discrepancy score. More...
odour identification		Depressed mood(depression)	symptoms	Clepce, 2010	patients only	Odour identification ability was significantly reduced durin...... Odour identification ability was significantly reduced during the depressive state. More...
olfactory hedonics		Anhedonia(anhedonia)	symptoms	Clepce, 2010	patients only	During the depressive episode, we found a significant relati...... During the depressive episode, we found a significant relation only between anhedonia and olfactory hedonics. More...

Positive relationship network of Sensation in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships betweenSensation and MDD (count: 0)

Negative relationships between Sensation and other level components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
sensory		Depressed mood(depression)	symptoms	Giesecke, 2005	patients and normal controls		Neither the level of symptoms of depression nor the presence...... Neither the level of symptoms of depression nor the presence of comorbid MDD was associated with the results of sensory testing or the magnitude of neuronal activation in brain areas associated with the sensory dimension of pain (primary and secondary somatosensory cortices). More...