Neurobiological Component Report

Basic Information

Name	N200
Description	The N200, or N2, is an event-related potential (ERP) component. The N200 in particular is a negative-going wave that peaks 200-350ms post-stimulus and is found primarily over anterior scalp sites.
Picture	From Wiki.
No. of Studies (Positive/Negative)	8 (8/0)

Positive relationship between N200 and MDD (count: 4)

Name in Literature	Reference	Research Type	Relation Description
N2	Holmes, 2008	patients and normal controls	Compared to healthy controls, MDD subjects showed reduced N2...... Compared to healthy controls, MDD subjects showed reduced N2 amplitudes. More...
N2	Kaiser, 2003	patients and normal controls	in the Nogo task depressive patients showed a reduction of a...... in the Nogo task depressive patients showed a reduction of an early fronto-temporal positivity in the N2 time window, which was associated with response inhibition in healthy subjects. More...
N270	Mao, 2005	patients and normal controls	A negative ERP component, N270, which was considered to refl...... A negative ERP component, N270, which was considered to reflect conflict processing activity in human brain, was evoked by S2 of the mismatch condition. The patient group showed a delayed and smaller N270 than the control group. More...
N2	Yang, 2011	patients only	MDD patients showed relatively high N2 amplitudes to negativ...... MDD patients showed relatively high N2 amplitudes to negative compared with positive target stimuli. MDD patients showed marginally reduced N2 amplitude to positive target stimuli compared with controls. More...

Positive relationships between N200 and other components at different levels (count: 8)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
N2		TNF(TNF)	gene	Beste, 2010	normal people	Compared with the TNF GG genotype group, attentional proces...... Compared with the TNF GG genotype group, attentional processes (N1) were enhanced in the combined AA/AG genotype group, while conflict processing functions (N2) and the selection of actions (LRP) were reduced. More...
N2		Protein S100-B(S100B)	protein	Dietrich, 2004	patients only	Patients with increased S100B serum levels (n=6) showed a no...... Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). More...
negative activity in the 157-210 ms section of the waveform		Perception(abnormal perceptual processing)	cognition and behavior	Pelosi, 2000	patients and normal controls	Surface negative activity in the 157-210 ms section of the w...... Surface negative activity in the 157-210 ms section of the waveform was reduced for all levels of memory load, suggesting abnormal sensory/perceptual processing in the modality-specific association cortices. More...
negative activity in the 157-210 ms section of the waveform		Sensation(abnormal sensory processing)	cognition and behavior	Pelosi, 2000	patients and normal controls	Surface negative activity in the 157-210 ms section of the w...... Surface negative activity in the 157-210 ms section of the waveform was reduced for all levels of memory load, suggesting abnormal sensory/perceptual processing in the modality-specific association cortices. More...
N2		Cognitive control(inhibition)	cognition and behavior	Kaiser, 2003	patients and normal controls	in the Nogo task depressive patients showed a reduction of a...... in the Nogo task depressive patients showed a reduction of an early fronto-temporal positivity in the N2 time window, which was associated with response inhibition in healthy subjects. More...
N270		Cognitive performance(cognitive impairment)	cognition and behavior	Mao, 2005	patients and normal controls	The results indicate that MDD patients as a group showed cog...... The results indicate that MDD patients as a group showed cognitive decline. N270 is a sensitive index in revealing cognitive impairment. More...
N270		Conflict processing(conflict processing)	cognition and behavior	Mao, 2005	patients and normal controls	A negative ERP component, N270, which was considered to refl...... A negative ERP component, N270, which was considered to reflect conflict processing activity in human brain, was evoked by S2 of the mismatch condition. More...
N2		Depressed mood(depressive symptomatology)	symptoms	Krompinger, 2009	high-risk people and normal controls	Examination of ERPs on trials uncontaminated by task-switchi...... Examination of ERPs on trials uncontaminated by task-switching effects revealed larger N2s on no-go than go trials, and, specific to the depressive group, larger N2s in response to positive compared to negative stimuli. More...

Positive relationship network of N200 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between N200 and MDD (count: 0)

Negative relationships between N200 and other components at different levels (count: 0)