MK4MDD

Gene Report

Basic Information
Approved Symbol TNF
Approved Name tumor necrosis factor
Previous Symbol TNFA
Previous Name "tumor necrosis factor (TNF superfamily, member 2)"
Symbol Alias TNFSF2, DIF, TNF-alpha
Name Alias "TNF superfamily, member 2"
Location 6p21.3
Position chr6:31545315-31546113 (+)
External Links Entrez Gene: 7124
Ensembl: ENSG00000232810
UCSC: uc003nui.4
HGNC ID: 11892
No. of Studies (Positive/Negative) 7(7/0) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between TNF and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
TNF Bosker, 2010 patients and normal controls OR T = 1.35, 95% CI 1.13-1.63; P-value = 0.0034 the only gene for which the association with MDD remained si...... the only gene for which the association with MDD remained significant after correction for multiple testing (rs76917; OR T = 1.35, 95% CI 1.13-1.63; P = 0.0034) More...
tumour necrosis factor-alpha Jun, 2003 patients and normal controls P-value<0.05 Genotype and allele distributions in patients with MDD (P=0....... Genotype and allele distributions in patients with MDD (P=0.024 and P=0.0125, respectively), were significantly different from those of the controls. In particular, subjects with MDD had an increased frequency of the TNF2 (A) allele. More...
TNF-alpha Cerri, 2010 patients and normal controls OR 2.433, CI 1.09-5.43 In subjects affected by MD we found a higher percentage of t...... In subjects affected by MD we found a higher percentage of the GG genotype (84 vs. 68,3%; p = 0.007) and thus of the G allele (92 vs. 81,9%; p = 0.05).The GG genotype was associated with a greater risk of developing the disease (OR 2.433, CI 1.09-5.43). More...
TNF-alpha Cerri AP, 2009 Patients and nomal controls p=0.007 Our results evidenced a significantly higher percentage of t...... Our results evidenced a significantly higher percentage of the GG genotype in depressed subjects (84.0% vs. 68.3%; p=0.007) and consequently of the G allele (92.0% vs. 81.9%; p=0.05). The presence of the GG genotype raised the risk of developing MD (odds ratio=OR=2.433, confidence interval=Cl=1.09-5.43). More...
TNF Carvalho LA, 2014 patients and normal controls FC=1.8; P-value=0.002 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...
TNF Savitz J, 2013 patients and normal controls FC=1.38; P-value=0.0014716

Positive relationships between TNF and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of TNF in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between TNF and MDD (count: 0)
Negative relationships between TNF and other components at different levels (count: 0) Help
TNF related SNPs in MK4MDD (count: 1)
TNF related proteins in MK4MDD (count: 1)
TNF related GO terms (count: 127)
TNF related KEGG pathways (count: 23)
TNF related BioCarta pathways (count: 20)
TNF related Reactome pathways (count: 2)
TNF related interactors from protein-protein interaction data in HPRD (count: 13)