Pathway Report

Name	apoptosis
GO Link	ID: GO:0006915 Name: apoptotic process Type: biological process
Description	"Genes annotated by the GO term GO:0006915. A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface."
No. of Studies (Positive/Negative)	2 (2/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Apoptosis		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
Apoptosis		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Bergstrom A, 2007	animal model		upregulation of apoptotic pathway upregulation of apoptotic pathway
Apoptosis		Stress(stress)	environment	Tordera RM, 2011	animal model		After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
LITAF	lipopolysaccharide-induced TNF factor	Literature-origin	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	Literature-origin	1(1/0)
PRKCB	protein kinase C, beta	Literature-origin; Protein mapped	1(1/0)
IRF3	interferon regulatory factor 3	Literature-origin	1(1/0)
VIM	vimentin	Literature-origin; Protein mapped	1(1/0)
SEPT4	septin 4	Literature-origin	1(1/0)
BAX	BCL2-associated X protein	Literature-origin	1(1/0)
GREM1	gremlin 1, DAN family BMP antagonist	Literature-origin	1(1/0)
LTA	lymphotoxin alpha	Literature-origin	2(1/1)
APLP1	amyloid beta (A4) precursor-like protein 1	Literature-origin	1(1/0)
IFNG	interferon, gamma	Literature-origin; Protein mapped	1(1/0)
APC	adenomatous polyposis coli	Literature-origin	1(1/0)
PLSCR1	phospholipid scramblase 1	Literature-origin	1(1/0)
ZBTB16	zinc finger and BTB domain containing 16	Literature-origin	1(1/0)
TJP2	tight junction protein 2	Literature-origin	1(1/0)
PDE1B	phosphodiesterase 1B, calmodulin-dependent	Literature-origin	1(1/0)
MAL	mal, T-cell differentiation protein	Literature-origin	1(1/0)
PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	Literature-origin	1(1/0)
EP300	E1A binding protein p300	Literature-origin	1(1/0)
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Literature-origin	2(2/0)
IL24	interleukin 24	Literature-origin	1(1/0)
CKAP2	cytoskeleton associated protein 2	Literature-origin	1(1/0)
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Literature-origin	1(0/1)
PRF1	perforin 1 (pore forming protein)	Literature-origin	1(1/0)
PTPN6	protein tyrosine phosphatase, non-receptor type 6	Literature-origin	1(1/0)
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Literature-origin	1(1/0)
CADM1	cell adhesion molecule 1	Literature-origin	1(0/1)
PAWR	PRKC, apoptosis, WT1, regulator	Literature-origin; Protein mapped	2(1/1)
CAPN3	calpain 3, (p94)	Literature-origin	1(1/0)
TNFRSF25	tumor necrosis factor receptor superfamily, member 25	Literature-origin	1(1/0)
PLAGL1	pleiomorphic adenoma gene-like 1	Literature-origin	1(1/0)
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	Literature-origin	1(1/0)
BCL2L1	BCL2-like 1	Literature-origin	1(1/0)
IL1B	interleukin 1, beta	Literature-origin; Protein mapped	4(3/1)
THOC1	THO complex 1	Literature-origin	1(1/0)
MAPK14	mitogen-activated protein kinase 14	Literature-origin	1(1/0)
DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	Literature-origin	1(1/0)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	Literature-origin	1(0/1)
COMP	cartilage oligomeric matrix protein	Literature-origin	1(1/0)
FGFR2	fibroblast growth factor receptor 2	Literature-origin	2(2/0)
IL1A	interleukin 1, alpha	Literature-origin	2(2/0)
MAPK8	mitogen-activated protein kinase 8	Literature-origin	1(1/0)
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	Literature-origin	1(1/0)
PRKCQ	protein kinase C, theta	Literature-origin	1(1/0)
PTK2B	protein tyrosine kinase 2 beta	Literature-origin	2(2/0)