Pathway Report

Name	apoptosis
GO Link	ID: GO:0006915 Name: apoptotic process Type: biological process
Description	Genes annotated by the GO term GO:0006915. A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
No. of Studies (Positive/Negative)	2 (2/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Apoptosis		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
Apoptosis		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Bergstrom A, 2007	animal model		upregulation of apoptotic pathway upregulation of apoptotic pathway
Apoptosis		Stress(stress)	environment	Tordera RM, 2011	animal model		After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
PSEN1	presenilin 1	Literature-origin	1(1/0)
CAPN3	calpain 3, (p94)	Literature-origin	1(1/0)
PTK2B	protein tyrosine kinase 2 beta	Literature-origin	2(2/0)
MAPK8	mitogen-activated protein kinase 8	Literature-origin	1(1/0)
IL1B	interleukin 1, beta	Literature-origin; SNP mapped; Protein mapped	3(2/1)
ZBTB16	zinc finger and BTB domain containing 16	Literature-origin	1(1/0)
TIAM1	T-cell lymphoma invasion and metastasis 1	Literature-origin	1(1/0)
TRIO	trio Rho guanine nucleotide exchange factor	Literature-origin	1(1/0)
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Literature-origin	1(1/0)
THOC1	THO complex 1	Literature-origin	1(1/0)
TJP2	tight junction protein 2	Literature-origin	1(1/0)
TNFRSF25	tumor necrosis factor receptor superfamily, member 25	Literature-origin	1(1/0)
LITAF	lipopolysaccharide-induced TNF factor	Literature-origin	1(1/0)
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	Literature-origin	1(1/0)
PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	Literature-origin	1(1/0)
PRKCQ	protein kinase C, theta	Literature-origin	1(1/0)
PLSCR1	phospholipid scramblase 1	Literature-origin	1(1/0)
PTPN6	protein tyrosine phosphatase, non-receptor type 6	Literature-origin	1(1/0)
FGFR2	fibroblast growth factor receptor 2	Literature-origin	2(2/0)
DICER1	dicer 1, ribonuclease type III	Literature-origin	1(1/0)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
PCNT	pericentrin	Literature-origin; SNP mapped	1(1/0)
IFNG	interferon, gamma	Literature-origin; Protein mapped	1(1/0)
VIM	vimentin	Literature-origin; Protein mapped	1(1/0)
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	Literature-origin; Protein mapped	2(2/0)
PAWR	PRKC, apoptosis, WT1, regulator	Literature-origin; Protein mapped	2(1/1)
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	Literature-origin; Protein mapped	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
NGFR	nerve growth factor receptor	Literature-origin; SNP mapped	1(0/1)
DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	Literature-origin	1(1/0)
TNF	tumor necrosis factor	Literature-origin; SNP mapped; Protein mapped	5(5/0)
APC	adenomatous polyposis coli	Literature-origin; SNP mapped	1(1/0)
FGFR3	fibroblast growth factor receptor 3	Literature-origin	2(2/0)
EP300	E1A binding protein p300	Literature-origin	1(1/0)
COMP	cartilage oligomeric matrix protein	Literature-origin	1(1/0)
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	Literature-origin	1(0/1)
IL1A	interleukin 1, alpha	Literature-origin	2(2/0)
APLP1	amyloid beta (A4) precursor-like protein 1	Literature-origin	1(1/0)
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Literature-origin	1(1/0)
GREM1	gremlin 1, DAN family BMP antagonist	Literature-origin	1(1/0)
PDE1B	phosphodiesterase 1B, calmodulin-dependent	Literature-origin	1(1/0)
FGF2	fibroblast growth factor 2 (basic)	Literature-origin	2(2/0)
SEPT4	septin 4	Literature-origin	1(1/0)
BCL2L1	BCL2-like 1	Literature-origin	1(1/0)
IL24	interleukin 24	Literature-origin	1(1/0)
BAX	BCL2-associated X protein	Literature-origin	1(1/0)