Gene Report

Basic Information

Approved Symbol	PCNT
Approved Name	pericentrin
Previous Symbol	PCNT2
Previous Name	"pericentrin 2 (kendrin)"
Symbol Alias	KEN, KIAA0402, PCN, PCNTB, SCKL4
Name Alias	"kendrin", "Seckel syndrome 4"
Location	21q22.3
Position	chr21:47865241-47865682 (+)
External Links	Entrez Gene: 5116 Ensembl: ENSG00000160299 UCSC: uc002zji.4 HGNC ID: 16068
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between PCNT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PCNT	Numata, 2009	patients and normal controls	P-value<0.05	We found a significant allelic association between 3 SNPs (r...... We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively) More...

Positive relationships between PCNT and other components at different levels (count: 0)

Positive relationship network of PCNT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PCNT and MDD (count: 0)

Negative relationships between PCNT and other components at different levels (count: 0)

PCNT related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs2073380	chr21:46443844(Forward)		1(1/0)
rs2073376	chr21:46431839(Forward)		1(1/0)

PCNT related proteins in MK4MDD (count: 0)

PCNT related GO terms (count: 30)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005814	centriole	cellular component	IDA[24421332]
GO:0005874	microtubule	cellular component	IEA
GO:0043066	negative regulation of apoptotic process	biological process	IEA
GO:0021696	cerebellar cortex morphogenesis	biological process	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0031514	motile cilium	cellular component	IEA
GO:0045171	intercellular bridge	cellular component	IEA
GO:0034451	centriolar satellite	cellular component	IDA[22797915]
GO:0005737	cytoplasm	cellular component	IDA
GO:0021772	olfactory bulb development	biological process	IEA
GO:0035264	multicellular organism growth	biological process	IEA
GO:0035108	limb morphogenesis	biological process	IEA
GO:0005813	centrosome	cellular component	IDA[18955030\|19543530\|20186884\|21399614\|22797915]
GO:0005516	calmodulin binding	molecular function	IEA
GO:0001701	in utero embryonic development	biological process	IEA
GO:0036064	ciliary basal body	cellular component	IEA
GO:0005801	cis-Golgi network	cellular component	IEA
GO:0061351	neural precursor cell proliferation	biological process	IEA
GO:0001764	neuron migration	biological process	IEA
GO:0042384	cilium assembly	biological process	IDA[15337773]
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS
GO:0048854	brain morphogenesis	biological process	IEA
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0000242	pericentriolar material	cellular component	IEA
GO:0007052	mitotic spindle organization	biological process	IMP[25220058]
GO:0005515	protein binding	molecular function	IPI[12812986\|15094396\|16980960\|18955030\|20466722\|22797915\|24816561\|26638075]
GO:0006996	organelle organization	biological process	TAS
GO:0000278	mitotic cell cycle	biological process	TAS
GO:0000226	microtubule cytoskeleton organization	biological process	IMP[18955030]
GO:0090316	positive regulation of intracellular protein transport	biological process	IMP[22797915]

PCNT related KEGG pathways (count: 0)

PCNT related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
AKAPCENTROSOME_PATHWAY	akapcentrosome pathway	Protein Kinase A at the Centrosome	Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is t...... Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP350 (also known as AKAP450 and CGNAP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the on set of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kinase, having a catalytic domain homologous to the PKC family in the C-terminal region and a unique regulatory region in the N-terminal region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kinases and phophatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott). Another example of AKAP/PKA interaction is illustrated in the AKAP95 role in mitosis and chromosome dynamics pathway. More...

PCNT related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15364	loss of_nlp_from_mitotic_centrosomes	During interphase, Nlp interacts with gamma-tubulin ring com...... During interphase, Nlp interacts with gamma-tubulin ring complexes. Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome. Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity. More...
REACT_2203	g2 m_transition	Cyclin A can also form complexes with Cdc2 (Cdk1). Together ...... Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved in mitotic spindle structure and function, the breakdown of the nuclear envelope, and topological changes in chromosomes allowing resolution of their entanglement and condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis. More...
REACT_152	cell cycle_mitotic	The replication of the genome and the subsequent segregation...... The replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried out during a discrete temporal period known as the S (synthesis)-phase, and chromosome segregation occurs during a massive reorganization to cellular architecture at mitosis. Two gap-phases separate these major cell cycle events: G1 between mitosis and S-phase, and G2 between S-phase and mitosis. In the development of the human body, cells can exit the cell cycle for a period and enter a quiescent state known as G0, or terminally differentiate into cells that will not divide again, but undergo morphological development to carry out the wide variety of specialized functions of individual tissues. A family of protein serine/threonine kinases known as the cyclin-dependent kinases (CDKs) controls progression through the cell cycle. As the name suggests, the activity of the catalytic subunit is dependent on binding to a cyclin partner. The human genome encodes several cyclins and several CDKs, with their names largely derived from the order in which they were identified. The oscillation of cyclin abundance is one important mechanism by which these enzymes phosphorylate key substrates to promote events at the relevant time and place. Additional regulatory proteins and post-translational modifications ensure that CDK activity is precisely regulated, frequently confined to a narrow window of activity. More...
REACT_15479	centrosome maturation	The centrosome is the primary microtubule organizing center. The centrosome is the primary microtubule organizing center.

PCNT related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PCNT	TUBGCP3	No	in vivo	12221128
PCNT	DISC1	Yes	in vivo;yeast 2-hybrid	15094396
PCNT	TUBG1	No	in vivo	12221128
PCNT	TUBGCP2	No	in vivo	12221128
PCNT	CALM2	Yes	in vivo	12221128 , 10823944
PCNT	AKAP9	No	in vivo	12221128
PCNT	PCM1	Yes	in vitro;in vivo	11171385
PCNT	CEP55	No	in vivo	16198290

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways

Gene mapped Reactome pathways