MK4MDD

Gene Report

Basic Information
Approved Symbol DISC1
Approved Name disrupted in schizophrenia 1
Location 1q42.1
Position chr1:232172578-232177018 (+)
External Links Entrez Gene: 27185
Ensembl: ENSG00000162946
UCSC: uc010pxh.2
HGNC ID: 2888
No. of Studies (Positive/Negative) 3(3/0) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between DISC1 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
DISC1 Hashimoto, 2006 patients and normal controls; cell model P-value=0.005; odds ratio=1.46 We found that Cys704 allele of the Ser704Cys single-nucleoti...... We found that Cys704 allele of the Ser704Cys single-nucleotide polymorphism (SNP) was associated with an increased risk of developing MDD (P=0.005, odds ratio=1.46) and stronger evidence for association in a multi-marker haplotype analysis containing this SNP (P=0.002). More...
DISC1 Schosser, 2010 patients and normal controls A haplotypic association in the TSNAX-DISC1 gene regiowas fo...... A haplotypic association in the TSNAX-DISC1 gene regiowas found for both BD and MDD. More...
DISC1 Arias, 2014 Patients and nomal controls Evidence of association among rs3738401 (DISC1), rs1615409 a...... Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). More...

Positive relationships between DISC1 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of DISC1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between DISC1 and MDD (count: 0)
Negative relationships between DISC1 and other components at different levels (count: 0) Help
DISC1 related SNPs in MK4MDD (count: 3)
DISC1 related proteins in MK4MDD (count: 1)
DISC1 related GO terms (count: 37)
DISC1 related KEGG pathways (count: 0)
DISC1 related BioCarta pathways (count: 0)
DISC1 related Reactome pathways (count: 0)
DISC1 related interactors from protein-protein interaction data in HPRD (count: 19)