Reactome Pathway Report
Basic Information
| ID |
|
| Name |
loss of_nlp_from_mitotic_centrosomes
|
| Description |
During interphase, Nlp interacts with gamma-tubulin ring complexes. Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome. Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.
|
REACT_15364 related genes in MK4MDD (count: 8)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| TUBB |
tubulin, beta class I |
Protein mapped
|
0(0/0) |
| CEP250 |
centrosomal protein 250kDa |
Literature-origin
|
1(1/0) |
| PRKACA |
protein kinase, cAMP-dependent, catalytic, alpha |
Protein mapped
|
0(0/0) |
| PCNT |
pericentrin |
Literature-origin; SNP mapped
|
1(1/0) |
| PRKAR2B |
protein kinase, cAMP-dependent, regulatory, type II, beta |
Literature-origin
|
1(1/0) |
| DCTN2 |
dynactin 2 (p50) |
Protein mapped
|
0(0/0) |
| YWHAE |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide |
Literature-origin
|
1(0/1) |
| PCM1 |
pericentriolar material 1 |
Literature-origin
|
1(1/0) |
