Gene Report

Basic Information

Approved Symbol	PLSCR1
Approved Name	phospholipid scramblase 1
Symbol Alias	MMTRA1B
Location	3q23
Position	chr3:146232967-146262628 (-)
External Links	Entrez Gene: 5359 Ensembl: ENSG00000188313 UCSC: uc003evx.4 HGNC ID: 9092
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PLSCR1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PLSCR1	Spijker, 2010	patients and normal controls		Based on LPS-stimulated blood gene expression using whole-ge...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More...

Positive relationships between PLSCR1 and other components at different levels (count: 0)

Positive relationship network of PLSCR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PLSCR1 and MDD (count: 0)

Negative relationships between PLSCR1 and other components at different levels (count: 0)

PLSCR1 related SNPs in MK4MDD (count: 0)

PLSCR1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Phospholipid scramblase 1	O15162	0(0/0)	Gene mapped

PLSCR1 related GO terms (count: 31)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	IDA[10770950]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[16091359]
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	biological process	ISS
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	biological process	IDA[17567603]
GO:0005154	epidermal growth factor receptor binding	molecular function	IPI[12009895]
GO:0003677	DNA binding	molecular function	IEA
GO:0005730	nucleolus	cellular component	IDA[17567603]
GO:0035456	response to interferon-beta	biological process	IMP[15308695]
GO:0005634	nucleus	cellular component	IDA
GO:0005887	integral to plasma membrane	cellular component	IDA[12586838]
GO:0042609	CD4 receptor binding	molecular function	IPI[19333378]
GO:0005829	cytosol	cellular component	IDA[17712045]
GO:0005515	protein binding	molecular function	IPI
GO:0017121	phospholipid scrambling	biological process	IDA[10770950]
GO:0006953	acute-phase response	biological process	ISS
GO:0051607	defense response to virus	biological process	IMP[15308695]
GO:0033003	regulation of mast cell activation	biological process	ISS
GO:0005794	Golgi apparatus	cellular component	IDA[12586838]
GO:0005509	calcium ion binding	molecular function	IDA[18629440]; NAS[9218461]
GO:0045071	negative regulation of viral genome replication	biological process	IMP[15308695]
GO:0045121	membrane raft	cellular component	IDA[12009895]
GO:0045089	positive regulation of innate immune response	biological process	IMP[15308695]
GO:0031012	extracellular matrix	cellular component	IDA
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IDA[16091359]
GO:0010628	positive regulation of gene expression	biological process	IMP[15308695]
GO:0019899	enzyme binding	molecular function	IPI[12586838]
GO:0030168	platelet activation	biological process	NAS[9218461]
GO:0017128	phospholipid scramblase activity	molecular function	IDA[10770950]
GO:0005886	plasma membrane	cellular component	IDA[19333378]
GO:0017124	SH3 domain binding	molecular function	IDA[11390389]
GO:0006659	phosphatidylserine biosynthetic process	biological process	ISS

PLSCR1 related KEGG pathways (count: 0)

PLSCR1 related BioCarta pathways (count: 0)

PLSCR1 related Reactome pathways (count: 0)

PLSCR1 related interactors from protein-protein interaction data in HPRD (count: 72)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PLSCR1	MED15	No	yeast 2-hybrid	16189514
PLSCR1	EFEMP2	No	yeast 2-hybrid	16189514
PLSCR1	EXD3	No	yeast 2-hybrid	16189514
PLSCR1	DLK2	No	yeast 2-hybrid	16189514
PLSCR1	ATG12	No	yeast 2-hybrid	16189514
PLSCR1	DTX2	No	yeast 2-hybrid	16189514
PLSCR1	FAM113A	No	yeast 2-hybrid	16189514
PLSCR1	LASP1	No	yeast 2-hybrid	16189514
PLSCR1	ILF3	No	yeast 2-hybrid	16189514
PLSCR1	GLRX3	No	yeast 2-hybrid	16189514
PLSCR1	YIPF3	No	yeast 2-hybrid	16189514
PLSCR1	SPRY2	No	yeast 2-hybrid	16189514
PLSCR1	SLC35A2	No	yeast 2-hybrid	16189514
PLSCR1	SHC1	No	in vivo	12009895
PLSCR1	VASP	No	yeast 2-hybrid	16189514
PLSCR1	TFG	No	yeast 2-hybrid	16189514
PLSCR1	SF1	Yes	yeast 2-hybrid	16189514
PLSCR1	C4orf42	No	yeast 2-hybrid	16189514
PLSCR1	SLPI	No	in vitro	10869562
PLSCR1	PLSCR3	No	yeast 2-hybrid	16189514
PLSCR1	C10orf54	No	yeast 2-hybrid	16189514
PLSCR1	KRTAP4-12	No	yeast 2-hybrid	16189514
PLSCR1	C10orf10	No	yeast 2-hybrid	16189514
PLSCR1	NPDC1	No	yeast 2-hybrid	16189514
PLSCR1	GNAI2	No	yeast 2-hybrid	16189514
PLSCR1	OGDH	No	yeast 2-hybrid	16189514
PLSCR1	GPRIN2	No	yeast 2-hybrid	16189514
PLSCR1	TRAF4	No	yeast 2-hybrid	12023963
PLSCR1	C10orf62	No	yeast 2-hybrid	16189514
PLSCR1	PLSCR4	No	yeast 2-hybrid	16189514
PLSCR1	DAZAP2	No	yeast 2-hybrid	16189514
PLSCR1	SMCP	No	yeast 2-hybrid	16189514
PLSCR1	FBXL18	No	yeast 2-hybrid	16189514
PLSCR1	ANXA11	No	yeast 2-hybrid	16189514
PLSCR1	EGFR	No	in vitro;in vivo	12009895 , 12871937
PLSCR1	C12orf12	No	yeast 2-hybrid	16189514
PLSCR1	NOC4L	No	yeast 2-hybrid	16189514
PLSCR1	CDC42EP1	No	yeast 2-hybrid	16189514
PLSCR1	HEY2	No	yeast 2-hybrid	16189514
PLSCR1	CPSF3L	No	yeast 2-hybrid	16189514
PLSCR1	SPG7	No	yeast 2-hybrid	16189514
PLSCR1	ATN1	No	yeast 2-hybrid	16713569
PLSCR1	PRKCD	No	in vitro;in vivo	10770950
PLSCR1	KIAA1683	No	yeast 2-hybrid	16189514
PLSCR1	ADAMTSL4	No	yeast 2-hybrid	16189514
PLSCR1	PHLDA1	No	yeast 2-hybrid	16189514
PLSCR1	HOXA9	No	yeast 2-hybrid	16189514
PLSCR1	NTN4	No	yeast 2-hybrid	16189514
PLSCR1	CPSF6	No	yeast 2-hybrid	16189514
PLSCR1	SLC25A6	No	yeast 2-hybrid	16189514
PLSCR1	CRK	No	yeast 2-hybrid	16189514
PLSCR1	FAM103A1	No	yeast 2-hybrid	16189514
PLSCR1	CRY1	Yes	yeast 2-hybrid	16189514
PLSCR1	PGLS	No	yeast 2-hybrid	16189514
PLSCR1	C16orf48	No	yeast 2-hybrid	16189514
PLSCR1	ZNF638	No	yeast 2-hybrid	16189514
PLSCR1	ZNF581	No	yeast 2-hybrid	16189514
PLSCR1	IP6K2	No	yeast 2-hybrid	16189514
PLSCR1	HOXB6	No	yeast 2-hybrid	16189514
PLSCR1	BACE1	Yes	in vitro;in vivo;yeast 2-hybrid	12586838
PLSCR1	RERE	No	yeast 2-hybrid	16713569
PLSCR1	CNTFR	No	yeast 2-hybrid	16189514
PLSCR1	CCDC33	No	yeast 2-hybrid	16189514
PLSCR1	NEU4	No	yeast 2-hybrid	16189514
PLSCR1	DHRS1	No	yeast 2-hybrid	16189514
PLSCR1	NECAP2	No	yeast 2-hybrid	16189514
PLSCR1	ZBTB16	Yes	yeast 2-hybrid	16189514
PLSCR1	EWSR1	No	yeast 2-hybrid	16189514
PLSCR1	HOXA1	No	yeast 2-hybrid	16189514
PLSCR1	ZNF764	No	yeast 2-hybrid	16189514
PLSCR1	ABL1	No	in vitro;in vivo	11390389
PLSCR1	RASD1	No	yeast 2-hybrid	16189514

Gene Report

Literature-origin GO terms

Gene mapped GO terms