Gene Report

Basic Information

Approved Symbol	SF1
Approved Name	splicing factor 1
Previous Symbol	ZNF162
Previous Name	"zinc finger protein 162"
Symbol Alias	ZFM1, ZCCHC25
Location	11q13
Position	chr11:64545865-64545938 (-)
External Links	Entrez Gene: 7536 Ensembl: ENSG00000168066 UCSC: uc001oaz.2 HGNC ID: 12950
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SF1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
D26121	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SF1 and other components at different levels (count: 0)

Positive relationship network of SF1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SF1 and MDD (count: 0)

Negative relationships between SF1 and other components at different levels (count: 0)

SF1 related SNPs in MK4MDD (count: 0)

SF1 related proteins in MK4MDD (count: 0)

SF1 related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0005840	ribosome	cellular component	NAS[8752089]
GO:0000389	mRNA 3'-splice site recognition	biological process	TAS[15647371]
GO:0005634	nucleus	cellular component	NAS[7912130]
GO:0005654	nucleoplasm	cellular component	IDA
GO:0000245	spliceosomal complex assembly	biological process	NAS[8752089]
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674\|22681889]
GO:0042802	identical protein binding	molecular function	IPI[22365833\|26420826]
GO:0005681	spliceosomal complex	cellular component	IDA[9731529]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0033327	Leydig cell differentiation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16189514\|17332742\|22365833\|25416956\|26420826]
GO:0003723	RNA binding	molecular function	TAS[8752089]
GO:0050810	regulation of steroid biosynthetic process	biological process	IEA
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IEA
GO:1903507	negative regulation of nucleic acid-templated transcription	biological process	TAS[9660765]
GO:0030238	male sex determination	biological process	IEA
GO:0003714	transcription corepressor activity	molecular function	TAS[9660765]
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[9731529]

SF1 related KEGG pathways (count: 0)

SF1 related BioCarta pathways (count: 0)

SF1 related Reactome pathways (count: 0)

SF1 related interactors from protein-protein interaction data in HPRD (count: 13)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SF1	PRKG1	No	in vitro	10449420
SF1	PRPF40A	No	in vitro	15456888
SF1	TRIM23	No	yeast 2-hybrid	16189514
SF1	EWSR1	No	in vitro;yeast 2-hybrid	9660765
SF1	TCERG1	No	in vitro;in vivo	11604498
SF1	BCL2	No	in vitro	8668206
SF1	RBPMS	No	yeast 2-hybrid	16189514
SF1	PLSCR1	Yes	yeast 2-hybrid	16189514
SF1	DDX17	No	yeast 2-hybrid	16189514
SF1	U2AF2	No	in vitro;yeast 2-hybrid	9150140 , 9512519
SF1	TAF15	No	in vitro	9660765
SF1	FUS	No	in vitro	9660765
SF1	WWP2	No	yeast 2-hybrid	16189514

Gene Report

Gene mapped GO terms