Gene Report

Basic Information

Approved Symbol	CRY1
Approved Name	cryptochrome circadian clock 1
Previous Symbol	PHLL1
Previous Name	"cryptochrome 1 (photolyase-like)"
Location	12q23-q24.1
Position	chr12:107486740-107487635 (-)
External Links	Entrez Gene: 1407 Ensembl: ENSG00000008405 UCSC: uc001tmi.4 HGNC ID: 2384
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CRY1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CRY1	Soria, 2010	patients and normal controls		In the MDD subsample, the same SNPs in CRY1 and NPAS2 of the...... In the MDD subsample, the same SNPs in CRY1 and NPAS2 of the combined sample remained associated More...

Positive relationships between CRY1 and other components at different levels (count: 0)

Positive relationship network of CRY1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CRY1 and MDD (count: 0)

Negative relationships between CRY1 and other components at different levels (count: 0)

CRY1 related SNPs in MK4MDD (count: 0)

CRY1 related proteins in MK4MDD (count: 0)

CRY1 related GO terms (count: 39)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006094	gluconeogenesis	biological process	ISS
GO:0031397	negative regulation of protein ubiquitination	biological process	ISS
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[12397359\|23133559]; ISS
GO:0033762	response to glucagon	biological process	ISS
GO:2000001	regulation of DNA damage checkpoint	biological process	ISS
GO:0006975	DNA damage induced protein phosphorylation	biological process	ISS
GO:0042593	glucose homeostasis	biological process	ISS
GO:0007623	circadian rhythm	biological process	TAS
GO:0018298	protein-chromophore linkage	biological process	IEA
GO:0035257	nuclear hormone receptor binding	molecular function	IPI[22170608]
GO:0043153	entrainment of circadian clock by photoperiod	biological process	ISS
GO:0009785	blue light signaling pathway	biological process	NAS[8909283]
GO:0019901	protein kinase binding	molecular function	IEA
GO:0019902	phosphatase binding	molecular function	IPI[9383998]
GO:0001047	core promoter binding	molecular function	ISS
GO:0005515	protein binding	molecular function	IPI[9383998\|17463251\|20852621\|21613214\|21680841\|23133559]
GO:0003677	DNA binding	molecular function	TAS[9801304]
GO:0032868	response to insulin	biological process	IEA
GO:0003904	deoxyribodipyrimidine photo-lyase activity	molecular function	IDA[8909283]
GO:0005634	nucleus	cellular component	ISS
GO:0043130	ubiquitin binding	molecular function	ISS
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0042826	histone deacetylase binding	molecular function	IEA
GO:0042752	regulation of circadian rhythm	biological process	ISS
GO:0019915	lipid storage	biological process	IEA
GO:0032922	circadian regulation of gene expression	biological process	ISS
GO:0005739	mitochondrion	cellular component	IEA
GO:2000850	negative regulation of glucocorticoid secretion	biological process	IEA
GO:0008134	transcription factor binding	molecular function	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[12397359\|14672706\|15147242]
GO:0009882	blue light photoreceptor activity	molecular function	NAS[8909283]
GO:0003690	double-stranded DNA binding	molecular function	IDA[9801304]
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IEA
GO:0003914	DNA (6-4) photolyase activity	molecular function	IDA[8909283]
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	biological process	ISS
GO:0042754	negative regulation of circadian rhythm	biological process	ISS
GO:0000989	transcription factor activity, transcription factor binding	molecular function	IDA[15147242]
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	biological process	ISS

CRY1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04710	circadian rhythm_mammal	Circadian rhythm - mammal

CRY1 related BioCarta pathways (count: 0)

CRY1 related Reactome pathways (count: 0)

CRY1 related interactors from protein-protein interaction data in HPRD (count: 11)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CRY1	KRTAP4-12	No	yeast 2-hybrid	16189514
CRY1	ARNTL	Yes	yeast 2-hybrid	10531061
CRY1	MDFI	No	yeast 2-hybrid	16189514
CRY1	CSNK1E	Yes	in vivo	11875063
CRY1	PER2	Yes	in vitro;in vivo;yeast 2-hybrid	11533252 , 10531061 , 10428031
CRY1	PER3	Yes	in vivo	10428031
CRY1	CBLB	Yes	yeast 2-hybrid	16189514
CRY1	PER1	Yes	in vitro;in vivo;yeast 2-hybrid	12782655 , 10531061
CRY1	TIMELESS	Yes	in vivo	10428031
CRY1	PLSCR1	Yes	yeast 2-hybrid	16189514
CRY1	TRAF2	No	yeast 2-hybrid	16189514

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways