Gene Report

Basic Information

Approved Symbol	TIAM1
Approved Name	T-cell lymphoma invasion and metastasis 1
Location	21q22.1
Position	chr21:32490736-32931290 (-)
External Links	Entrez Gene: 7074 Ensembl: ENSG00000156299 UCSC: uc002yow.1 HGNC ID: 11805
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between TIAM1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TIAM1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between TIAM1 and other components at different levels (count: 0)

Positive relationship network of TIAM1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TIAM1 and MDD (count: 0)

Negative relationships between TIAM1 and other components at different levels (count: 0)

TIAM1 related SNPs in MK4MDD (count: 0)

TIAM1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
T-lymphoma invasion and metastasis-inducing protein 1	Q13009	0(0/0)	Gene mapped

TIAM1 related GO terms (count: 14)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005829	cytosol	cellular component	TAS
GO:0005543	phospholipid binding	molecular function	IEA
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA
GO:0050772	positive regulation of axonogenesis	biological process	IEA
GO:0035023	regulation of Rho protein signal transduction	biological process	IEA
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS
GO:0048013	ephrin receptor signaling pathway	biological process	IEA
GO:0005911	cell-cell junction	cellular component	IDA
GO:0046875	ephrin receptor binding	molecular function	IEA
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS
GO:0005057	receptor signaling protein activity	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA

TIAM1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04810	regulation of_actin_cytoskeleton	Regulation of actin cytoskeleton

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04062	chemokine signaling_pathway	Chemokine signaling pathway	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. More...

TIAM1 related BioCarta pathways (count: 0)

TIAM1 related Reactome pathways (count: 7)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11051	rho gtpase_cycle	The cycling of Rho GTPases is tightly controlled by three cl...... The cycling of Rho GTPases is tightly controlled by three classes of protein. These are. More...
REACT_13776	p75 ntr_receptor_mediated_signalling	Besides signalling through the tyrosine kinase receptors TRK...... Besides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a number of downstream signalling events controlling survival, death, proliferation, and axonogenesis, according to the cellular context. p75NTR is devoid of enzymatic activity, and signals by recruiting other proteins to its own intracellular domain. p75 interacting proteins include NRIF, TRAF2, 4, and 6, NRAGE, necdin, SC1, NADE, RhoA, Rac, ARMS, RIP2, FAP and PLAIDD. Here we annotate only the proteins for which a clear involvement in p75NTR signalling was demonstrated. A peculiarity of p75NTR is the ability to bind the pro-neurotrophins proNGF and proBDNF. Proneurotrophins do not associate with TRK receptors, whereas they efficiently signal cell death by apoptosis through p75NTR. The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR, mediating apoptosis, and mature forms activating TRK receptors, to promote survival. Moreover, the two receptors are utilised to differentially modulate neuronal plasticity. For instance, proBDNF-p75NTR signalling facilitates LTD, long term depression, in the hippocampus , while BDNF-TRKB signalling promotes LTP (long term potentiation). Many biological observations indicate a functional interaction between p75NTR and TRKA signaling pathways. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_13638	nrage signals_death_through_jnk	Once bound by either NGF or proNGF, p75NTR interacts with NR...... Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here. More...
REACT_18407	g alpha_12_13_signalling_events	The alpha subunits of G12 and 13 bind RhoGEFs (guanine nucle...... The alpha subunits of G12 and 13 bind RhoGEFs (guanine nucleotide exchange factors, which activate small G proteins) providing a path to Rho-mediated cytoskeletal responses that are likely involved in shape change in platelets. More...
REACT_11061	signalling by_ngf	Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles i...... Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling. More...
REACT_13720	cell death_signalling_via_nrage_nrif_and_nade	p75NTR is a key regulator of neuronal apoptosis, both during...... p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. TRKA signalling protects neurons from apoptosis. The molecular mechanisms involved in p75NTR-apoptosis are not well understood. The death signalling requires activation of c-JUN N-terminal Kinase (JNK), as well as transcriptional events. JNK activation appears to involve the receptor interacting proteins TRAF6, NRAGE, and Rac. The transcription events are thought to be regulated by another p75-interacting protein, NRIF. Two other p75-interacting proteins, NADE and Necdin, have been implicated in apoptosis, but their role is less clear. More...

TIAM1 related interactors from protein-protein interaction data in HPRD (count: 21)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
TIAM1	MAPK8IP1	No	in vivo	12024021
TIAM1	YWHAG	No	in vivo	15324660
TIAM1	PRKCG	No	in vitro	10212259
TIAM1	HRAS	No	in vivo	12134164
TIAM1	EPHA2	No	in vitro;in vivo	14988728
TIAM1	PRKCA	No	in vitro;in vivo	10212259
TIAM1	MYC	No	in vitro;in vivo	12446731
TIAM1	TIAM1	Yes	in vitro;in vivo	12376551 , 14988728
TIAM1	CD44	No	in vitro;in vivo	10636882
TIAM1	MAPK8IP2	No	in vivo	12024021
TIAM1	NME1	No	in vivo	11274357
TIAM1	ABCA1	No	in vitro	16192287
TIAM1	PPP1R9B	No	in vivo;yeast 2-hybrid	12531897
TIAM1	PRKCD	No	in vitro	10212259
TIAM1	EFNB1	No	in vitro;in vivo	14988728
TIAM1	ANK1	No	in vitro;in vivo	10893266
TIAM1	SRC	No	in vitro;in vivo	12810717
TIAM1	PARD3	No	in vitro;in vivo	15723052
TIAM1	CAMK2G	No	in vitro;in vivo	10212259
TIAM1	PRKCE	No	in vitro	10212259
TIAM1	RAC1	No	in vitro;in vivo	11595749 , 11130063

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways