Reactome Pathway Report
Basic Information
| ID |
|
| Name |
nrage signals_death_through_jnk
|
| Description |
Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.
|
REACT_13638 related genes in MK4MDD (count: 7)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| ARHGEF2 |
Rho/Rac guanine nucleotide exchange factor (GEF) 2 |
Literature-origin
|
1(1/0) |
| TIAM1 |
T-cell lymphoma invasion and metastasis 1 |
Literature-origin
|
1(1/0) |
| TRIO |
trio Rho guanine nucleotide exchange factor |
Literature-origin
|
1(1/0) |
| RASGRF1 |
Ras protein-specific guanine nucleotide-releasing factor 1 |
Literature-origin
|
1(1/0) |
| NGFR |
nerve growth factor receptor |
Literature-origin; SNP mapped
|
1(0/1) |
| MAPK8 |
mitogen-activated protein kinase 8 |
Literature-origin
|
1(1/0) |
| PREX1 |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
Literature-origin
|
1(1/0) |
