Gene Report

Basic Information

Approved Symbol	COMP
Approved Name	cartilage oligomeric matrix protein
Previous Symbol	PSACH, EDM1, EPD1
Previous Name	cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
Symbol Alias	MED, THBS5
Name Alias	thrombospondin-5
Location	19p13.1
Position	chr19:18893583-18902114 (-)
External Links	Entrez Gene: 1311 Ensembl: ENSG00000105664 UCSC: uc002nke.3 HGNC ID: 2227
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between COMP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
COMP	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between COMP and other components at different levels (count: 0)

Positive relationship network of COMP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between COMP and MDD (count: 0)

Negative relationships between COMP and other components at different levels (count: 0)

COMP related SNPs in MK4MDD (count: 0)

COMP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cartilage oligomeric matrix protein	P49747	0(0/0)	Gene mapped

COMP related GO terms (count: 16)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008201	heparin binding	molecular function	IDA[17588949]
GO:0009887	organ morphogenesis	biological process	TAS[7713493]
GO:0031012	extracellular matrix	cellular component	IDA
GO:0005518	collagen binding	molecular function	IDA[11084047]
GO:0001501	skeletal system development	biological process	TAS[7670472]
GO:0005201	extracellular matrix structural constituent	molecular function	TAS[7713493]
GO:0005509	calcium ion binding	molecular function	IDA[11084047]
GO:0060173	limb development	biological process	IDA[16542502]
GO:0005515	protein binding	molecular function	IPI[16051604]
GO:0003417	growth plate cartilage development	biological process	IEA
GO:0043395	heparan sulfate proteoglycan binding	molecular function	IDA[17588949]
GO:0005615	extracellular space	cellular component	IDA
GO:0043066	negative regulation of apoptotic process	biological process	IDA[17993464]
GO:0007155	cell adhesion	biological process	IEA
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA

COMP related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04510	focal adhesion	Focal adhesion	Cell-matrix adhesions play essential roles in important biol...... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. More...
hsa04512	ecm receptor_interaction	ECM-receptor interaction	The extracellular matrix (ECM) consists of a complex mixture...... The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04350	tgf beta_signaling_pathway	TGF-beta signaling pathway	The transforming growth factor-beta (TGF-beta) family member...... The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. More...

COMP related BioCarta pathways (count: 0)

COMP related Reactome pathways (count: 0)

COMP related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
COMP	COL9A1	No	in vitro	15047691
COMP	FN1	No	in vitro	12225811
COMP	COL2A1	No	in vitro	9685393

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways