Gene Report

Basic Information

Approved Symbol	SEPT4
Approved Name	septin 4
Previous Symbol	PNUTL2
Previous Name	peanut-like 2 (Drosophila)
Symbol Alias	H5, CE5B3, hucep-7, ARTS, hCDCREL-2, MART
Name Alias	bradeoin, "septin-M"
Location	17q22
Position	chr17:56597611-56618179 (-)
External Links	Entrez Gene: 5414 Ensembl: ENSG00000108387 UCSC: uc002iwm.2 HGNC ID: 9165
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SEPT4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SEPT4	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between SEPT4 and other components at different levels (count: 0)

Positive relationship network of SEPT4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SEPT4 and MDD (count: 0)

Negative relationships between SEPT4 and other components at different levels (count: 0)

SEPT4 related SNPs in MK4MDD (count: 0)

SEPT4 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Septin-4	O43236	0(0/0)	Gene mapped

SEPT4 related GO terms (count: 21)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0005856	cytoskeleton	cellular component	IEA
GO:0006915	apoptotic process	biological process	NAS[11146656]
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007049	cell cycle	biological process	IEA
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	biological process	IMP
GO:0043065	positive regulation of apoptotic process	biological process	IDA
GO:0005739	mitochondrion	cellular component	NAS[11146656]
GO:0007420	brain development	biological process	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0005198	structural molecule activity	molecular function	TAS[9889007]
GO:0005515	protein binding	molecular function	IPI
GO:0006184	GTP catabolic process	biological process	TAS[9889007]
GO:0042981	regulation of apoptotic process	biological process	NAS[11146656]
GO:0031398	positive regulation of protein ubiquitination	biological process	IDA
GO:0000910	cytokinesis	biological process	TAS[9889007]
GO:0003924	GTPase activity	molecular function	TAS[9889007]
GO:0005525	GTP binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IDA; NAS[11146656]
GO:0048240	sperm capacitation	biological process	IEA
GO:0042995	cell projection	cellular component	IEA
GO:0030382	sperm mitochondrion organization	biological process	IEA

SEPT4 related KEGG pathways (count: 0)

SEPT4 related BioCarta pathways (count: 0)

SEPT4 related Reactome pathways (count: 0)

SEPT4 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms