Gene Report

Basic Information

Approved Symbol	DICER1
Approved Name	dicer 1, ribonuclease type III
Previous Symbol	MNG1
Previous Name	"Dicer1, Dcr-1 homolog (Drosophila)", "multinodular goitre 1"
Symbol Alias	Dicer, KIAA0928, K12H4.8-LIKE, HERNA
Name Alias	"dicer 1, double-stranded RNA-specific endoribonuclease"
Location	14q32.13
Position	chr14:95623567-95623759 (-)
External Links	Entrez Gene: 23405 Ensembl: ENSG00000100697 UCSC: uc001ydw.2 HGNC ID: 17098
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between DICER1 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DICER1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
DICER1	Jansen R, 2015	patients and normal controls	P-value=0.0000976;FDR=0.0853;beta=0.211	we found 129 genes (142 probesets) differentially expressed ...... we found 129 genes (142 probesets) differentially expressed between the control and current MDD groups (FDR<0.1) More...

Positive relationships between DICER1 and other components at different levels (count: 0)

Positive relationship network of DICER1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DICER1 and MDD (count: 0)

Negative relationships between DICER1 and other components at different levels (count: 0)

DICER1 related SNPs in MK4MDD (count: 0)

DICER1 related proteins in MK4MDD (count: 0)

DICER1 related GO terms (count: 78)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0070578	RISC-loading complex	cellular component	IDA[15973356\|16357216\|18178619\|19820710]
GO:0021889	olfactory bulb interneuron differentiation	biological process	IEA
GO:0031069	hair follicle morphogenesis	biological process	IEA
GO:0035196	production of miRNAs involved in gene silencing by miRNA	biological process	IDA[15973356\|23661684]; ISS
GO:0051726	regulation of cell cycle	biological process	IEA
GO:0060576	intestinal epithelial cell development	biological process	IEA
GO:0001525	angiogenesis	biological process	IEA
GO:0060119	inner ear receptor cell development	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[12526743\|14749716\|15973356\|16142218\|16424907\|17452327\|17932509\|18325616\|19716330\|19804757\|19820710\|20869963\|21903422\|23622242\|23661684\|23741051\|25446899\|25557550\|26496610]
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	cellular component	IEA
GO:0035116	embryonic hindlimb morphogenesis	biological process	IEA
GO:0030422	production of siRNA involved in RNA interference	biological process	IDA[15973356\|17452327\|23661684]
GO:0004530	deoxyribonuclease I activity	molecular function	IBA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:2000630	positive regulation of miRNA metabolic process	biological process	IEA
GO:0035197	siRNA binding	molecular function	IDA[15973356]
GO:0010628	positive regulation of gene expression	biological process	IEA
GO:0010467	gene expression	biological process	TAS
GO:0019904	protein domain specific binding	molecular function	IPI[12526743]
GO:0021987	cerebral cortex development	biological process	IEA
GO:0051216	cartilage development	biological process	IEA
GO:0035264	multicellular organism growth	biological process	IEA
GO:0048536	spleen development	biological process	IEA
GO:0030423	targeting of mRNA for destruction involved in RNA interference	biological process	IMP[15973356\|17452327]
GO:0030425	dendrite	cellular component	IEA
GO:0014040	positive regulation of Schwann cell differentiation	biological process	ISS
GO:0004525	ribonuclease III activity	molecular function	IDA[21753850]
GO:0006309	apoptotic DNA fragmentation	biological process	IBA
GO:0004386	helicase activity	molecular function	IEA
GO:0071335	hair follicle cell proliferation	biological process	IEA
GO:0003677	DNA binding	molecular function	IEA
GO:0035198	miRNA binding	molecular function	IEA
GO:0035068	micro-ribonucleoprotein complex	cellular component	IEA
GO:0030324	lung development	biological process	IEA
GO:0031054	pre-miRNA processing	biological process	IDA[15973356\|16357216\|18178619\|23661684\|25549615]
GO:0048812	neuron projection morphogenesis	biological process	ISS
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	biological process	IDA[18178619]
GO:0019827	stem cell population maintenance	biological process	IEA
GO:0033167	ARC complex	cellular component	IC[19701182]
GO:0003725	double-stranded RNA binding	molecular function	IDA[12411504]; IMP[19701182]
GO:0010070	zygote asymmetric cell division	biological process	IEA
GO:0014835	myoblast differentiation involved in skeletal muscle regeneration	biological process	IEA
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	biological process	IEA
GO:0005524	ATP binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IBA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0045664	regulation of neuron differentiation	biological process	IEA
GO:0048255	mRNA stabilization	biological process	IEA
GO:0035087	siRNA loading onto RISC involved in RNA interference	biological process	IDA[15973356]
GO:0051607	defense response to virus	biological process	IEA
GO:0032290	peripheral nervous system myelin formation	biological process	ISS
GO:0051225	spindle assembly	biological process	IEA
GO:0048754	branching morphogenesis of an epithelial tube	biological process	IEA
GO:0021522	spinal cord motor neuron differentiation	biological process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	ISS
GO:0005737	cytoplasm	cellular component	IBA
GO:0045069	regulation of viral genome replication	biological process	IEA
GO:0070173	regulation of enamel mineralization	biological process	IEA
GO:0004521	endoribonuclease activity	molecular function	IDA[25549615]; IMP[18325616\|19701182]; TAS[19820710]
GO:0048713	regulation of oligodendrocyte differentiation	biological process	IEA
GO:0048608	reproductive structure development	biological process	IEA
GO:0031047	gene silencing by RNA	biological process	TAS
GO:0010626	negative regulation of Schwann cell proliferation	biological process	ISS
GO:0031643	positive regulation of myelination	biological process	ISS
GO:0005829	cytosol	cellular component	TAS
GO:0033168	conversion of ds siRNA to ss siRNA involved in RNA interference	biological process	IMP[19701182]
GO:0009791	post-embryonic development	biological process	IEA
GO:0016442	RISC complex	cellular component	IDA[16357216]
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	biological process	IDA[21753850\|25549615]
GO:0036404	conversion of ds siRNA to ss siRNA	biological process	IMP[18325616]
GO:0070883	pre-miRNA binding	molecular function	IDA[18508075\|25549615]; IDA[18178619]
GO:0061548	ganglion development	biological process	IEA
GO:0021675	nerve development	biological process	ISS
GO:0010660	regulation of muscle cell apoptotic process	biological process	IEA
GO:0030426	growth cone	cellular component	IEA
GO:0055013	cardiac muscle cell development	biological process	IEA
GO:0030424	axon	cellular component	IEA
GO:0046872	metal ion binding	molecular function	IEA

DICER1 related KEGG pathways (count: 0)

DICER1 related BioCarta pathways (count: 0)

DICER1 related Reactome pathways (count: 1)

ID	Name	Description
Gene mapped Reactome pathways
REACT_12417	microrna biogenesis	1. Transcription. MicroRNA (miRNA) transcripts may come from...... 1. Transcription. MicroRNA (miRNA) transcripts may come from autonomously transcribed genes or they may be contained in cotranscripts with other genes. Most miRNAs are transcribed by RNA polymerase II, however a few miRNAs originate as RNA polymerase III cotranscripts with neighboring repetitive elements. The initial transcript, termed a primary microRNA (pri-miRNA), contains an imperfectly double-stranded region within a hairpin loop. Longer sequences extend from the 5' and 3' ends of the hairpin and may also contain double-stranded regions. 2. Cleavage by Drosha. The 5' and 3' ends of the pri-miRNA are removed during endoribonucleolytic cleavage by the Drosha nuclease in a complex with the RNA-binding protein DGCR8 (the Microprocessor complex). The cleavage product is a short hairpin of about 60 to 70 nt called the pre-microRNA (pre-miRNA). 3. Nuclear export by Exportin-5. The resulting pre-miRNA is bound by Exportin-5 in a complex with Ran and GTP. The complex translocates the pre-miRNA through the nuclear pore into the cytoplasm. 4. Cleavage by Dicer. Once in the cytoplasm the pre-miRNA is bound and cleaved by the Dicer ribonuclease in complex with the RNA-binding protein TRBP (TAR binding protein). The product is an imperfectly double-stranded miRNA of about 21 to 23 nucleotides. At this stage the double-stranded miRNA has protruding single-stranded 3' ends of 2-3 nt. 5. Strand selection and incorporation into RNA-Induced Silencing Complex (RISC). At this stage the miRNA has two strands: the passenger strand, which will be removed and degraded, and the guide strand, which will be retained and guides the RISC to target mRNAs. An Argonaute protein is already bound to the Dicer:miRNA complex or subsequently binds the complex (the order is unknown). The human genome encodes 4 Argonaute proteins, however only Argonaute2 can cleave target mRNAs with perfect or nearly perfect complementarity to the guide miRNA. In mammalian cells, such endogenous interactions are very rare; most miRNAs only cause translational repression. For complexes that contain Argonaute2, cleavage of the passenger strand of the double-stranded miRNA accompanies removal of the passenger strand. Complexes containing other Argonautes may use a helicase to remove the passenger strand but this is not fully known. The resulting single-stranded miRNA (the guide strand) remains in a complex containing Argonaute, Dicer, TRBP, and other proteins termed the RNA-induced Silencing Complex (RISC). The full set of proteins composing RISC is not yet known. More...

DICER1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DICER1	PIWIL4	No	in vitro;yeast 2-hybrid	14749716
DICER1	TARBP2	No	in vitro;in vivo	16424907 , 16142218 , 15973356
DICER1	EIF2C1	No	in vivo	12526743
DICER1	PIWIL1	No	in vitro	14749716
DICER1	EIF2C2	No	in vivo	12526743
DICER1	PIWIL2	No	in vitro;in vivo	12906857
DICER1	PRKRA	No	in vivo	16424907

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways