Gene Report

Basic Information

Approved Symbol	THOC1
Approved Name	THO complex 1
Symbol Alias	P84, HPR1
Location	18p11.32
Position	chr18:214520-268059 (-)
External Links	Entrez Gene: 9984 Ensembl: ENSG00000079134 UCSC: uc002kkj.4 HGNC ID: 19070
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between THOC1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Nuclear matrix protein p84	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between THOC1 and other components at different levels (count: 0)

Positive relationship network of THOC1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between THOC1 and MDD (count: 0)

Negative relationships between THOC1 and other components at different levels (count: 0)

THOC1 related SNPs in MK4MDD (count: 0)

THOC1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
THO complex subunit 1	Q96FV9	0(0/0)	Gene mapped

THOC1 related GO terms (count: 20)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	IDA[10512864]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0032784	regulation of DNA-dependent transcription, elongation	biological process	IDA[15870275]
GO:0005515	protein binding	molecular function	IPI[15870275]
GO:0046784	intronless viral mRNA export from host nucleus	biological process	IDA[18974867]
GO:0005730	nucleolus	cellular component	IDA
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0003723	RNA binding	molecular function	IEA
GO:0008380	RNA splicing	biological process	IEA
GO:0000445	THO complex part of transcription export complex	cellular component	IDA[15998806]
GO:0005737	cytoplasm	cellular component	IDA[15358532]
GO:0006397	mRNA processing	biological process	IEA
GO:0006396	RNA processing	biological process	TAS[7525595]
GO:0003677	DNA binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IDA
GO:0006406	mRNA export from nucleus	biological process	IDA[17190602]
GO:0016607	nuclear speck	cellular component	IEA
GO:0000347	THO complex	cellular component	IDA[15998806]
GO:0000346	transcription export complex	cellular component	IDA[15833825]
GO:0007165	signal transduction	biological process	IEA
GO:0016363	nuclear matrix	cellular component	IEA

THOC1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa03040	spliceosome	Spliceosome	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

THOC1 related BioCarta pathways (count: 0)

THOC1 related Reactome pathways (count: 0)

THOC1 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways