
Gene Report
Approved Symbol | FGFR2 |
---|---|
Approved Name | fibroblast growth factor receptor 2 |
Previous Symbol | KGFR, BEK, CFD1, JWS |
Previous Name | bacteria-expressed kinase, "keratinocyte growth factor receptor", "craniofacial dysostosis 1", "Jackson-Weiss syndrome" |
Symbol Alias | CEK3, TK14, TK25, ECT1, K-SAM, CD332 |
Name Alias | Crouzon syndrome, "Pfeiffer syndrome" |
Location | 10q25.3-q26 |
Position | chr10:123237844-123357972 (-) |
External Links |
Entrez Gene: 2263 Ensembl: ENSG00000066468 UCSC: uc021pzy.1 HGNC ID: 3689 |
No. of Studies (Positive/Negative) | 2(2/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
FGFR2 | Aston, 2005 | patients and normal controls | Genes altered in major depressive disorder Genes altered in major depressive disorder | ||
FGFR 2 | Evans, 2004 | patients and normal controls | Of the 10 FGF transcripts reliably detected, 4 were signific...... Of the 10 FGF transcripts reliably detected, 4 were significantly differentially expressed in the DLPFC of MDD subjects, including 2 FGF receptors (FGFR 2 and 3) and 2 FGF ligands (FGF 1 and 9) More... |
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Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Fibroblast growth factor receptor 2 | P21802 | 0(0/0) | Gene mapped |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006915 | apoptotic process | biological process | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0040014 | regulation of multicellular organism growth | biological process | ISS | |
GO:0043410 | positive regulation of MAPK cascade | biological process | IMP[15629145] | |
GO:0010453 | regulation of cell fate commitment | biological process | ISS | |
GO:0090263 | positive regulation of canonical Wnt receptor signaling pathway | biological process | ISS | |
GO:0042472 | inner ear morphogenesis | biological process | ISS | |
GO:0042803 | protein homodimerization activity | molecular function | IPI[16844695] | |
GO:0060595 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification | biological process | ISS | |
GO:0001657 | ureteric bud development | biological process | ISS | |
GO:0031012 | extracellular matrix | cellular component | IDA[17959718] | |
GO:0010518 | positive regulation of phospholipase activity | biological process | IMP[16844695] | |
GO:0048557 | embryonic digestive tract morphogenesis | biological process | ISS | |
GO:0009791 | post-embryonic development | biological process | ISS | |
GO:0045667 | regulation of osteoblast differentiation | biological process | TAS[15190072] | |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological process | ISS | |
GO:0051150 | regulation of smooth muscle cell differentiation | biological process | ISS | |
GO:0045165 | cell fate commitment | biological process | ISS | |
GO:0032808 | lacrimal gland development | biological process | ISS | |
GO:0008201 | heparin binding | molecular function | IEA | |
GO:0018108 | peptidyl-tyrosine phosphorylation | biological process | IDA[16844695] | |
GO:0033688 | regulation of osteoblast proliferation | biological process | TAS[15190072] | |
GO:0048705 | skeletal system morphogenesis | biological process | TAS[15190072] | |
GO:0035602 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow | biological process | ISS | |
GO:0060365 | coronal suture morphogenesis | biological process | IEA | |
GO:0008543 | fibroblast growth factor receptor signaling pathway | biological process | IDA[15629145]; IGI[8663044]; IPI[10830168]; TAS | |
GO:0060670 | branching involved in labyrinthine layer morphogenesis | biological process | ISS | |
GO:0051781 | positive regulation of cell division | biological process | ISS | |
GO:0030901 | midbrain development | biological process | ISS | |
GO:0030282 | bone mineralization | biological process | ISS | |
GO:0060484 | lung-associated mesenchyme development | biological process | ISS | |
GO:0017134 | fibroblast growth factor binding | molecular function | IDA[8663044]; IPI[11923311] | |
GO:0045787 | positive regulation of cell cycle | biological process | ISS | |
GO:0060664 | epithelial cell proliferation involved in salivary gland morphogenesis | biological process | ISS | |
GO:0060348 | bone development | biological process | ISS | |
GO:0022612 | gland morphogenesis | biological process | ISS | |
GO:0016023 | cytoplasmic membrane-bounded vesicle | cellular component | IEA | |
GO:0016020 | membrane | cellular component | NAS[8676562] | |
GO:0008589 | regulation of smoothened signaling pathway | biological process | ISS | |
GO:0045839 | negative regulation of mitosis | biological process | IEA | |
GO:0005576 | extracellular region | cellular component | IEA | |
GO:0005515 | protein binding | molecular function | IPI[1309608] | |
GO:0009880 | embryonic pattern specification | biological process | ISS | |
GO:0050679 | positive regulation of epithelial cell proliferation | biological process | ISS | |
GO:0005887 | integral to plasma membrane | cellular component | IDA[16844695] | |
GO:0070307 | lens fiber cell development | biological process | IEA | |
GO:0035264 | multicellular organism growth | biological process | ISS | |
GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | biological process | ISS | |
GO:0021847 | ventricular zone neuroblast division | biological process | ISS | |
GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | biological process | ISS | |
GO:0030324 | lung development | biological process | ISS | |
GO:0048608 | reproductive structure development | biological process | ISS | |
GO:0005737 | cytoplasm | cellular component | IDA[16597614] | |
GO:0046777 | protein autophosphorylation | biological process | IDA[15629145] | |
GO:0030177 | positive regulation of Wnt receptor signaling pathway | biological process | ISS | |
GO:0060463 | lung lobe morphogenesis | biological process | ISS | |
GO:0001701 | in utero embryonic development | biological process | ISS | |
GO:0070372 | regulation of ERK1 and ERK2 cascade | biological process | ISS | |
GO:0048565 | digestive tract development | biological process | ISS | |
GO:0035265 | organ growth | biological process | ISS | |
GO:0005938 | cell cortex | cellular component | IDA[17471512] | |
GO:0042802 | identical protein binding | molecular function | IPI | |
GO:0005524 | ATP binding | molecular function | IEA | |
GO:0060601 | lateral sprouting from an epithelium | biological process | ISS | |
GO:0048489 | synaptic vesicle transport | biological process | IEA | |
GO:0007528 | neuromuscular junction development | biological process | IEA | |
GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development | biological process | ISS | |
GO:0008285 | negative regulation of cell proliferation | biological process | IEA | |
GO:0003149 | membranous septum morphogenesis | biological process | ISS | |
GO:0060045 | positive regulation of cardiac muscle cell proliferation | biological process | ISS | |
GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis | biological process | ISS | |
GO:0055010 | ventricular cardiac muscle tissue morphogenesis | biological process | ISS | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | ISS | |
GO:0060688 | regulation of morphogenesis of a branching structure | biological process | ISS | |
GO:0060687 | regulation of branching involved in prostate gland morphogenesis | biological process | ISS | |
GO:0021860 | pyramidal neuron development | biological process | ISS | |
GO:0005634 | nucleus | cellular component | IDA[16597614] | |
GO:0060174 | limb bud formation | biological process | ISS | |
GO:0007267 | cell-cell signaling | biological process | ISS | |
GO:0009887 | organ morphogenesis | biological process | ISS | |
GO:0060076 | excitatory synapse | cellular component | ISS | |
GO:0060527 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | biological process | ISS | |
GO:0048762 | mesenchymal cell differentiation | biological process | ISS | |
GO:0008286 | insulin receptor signaling pathway | biological process | TAS | |
GO:0060523 | prostate epithelial cord elongation | biological process | ISS | |
GO:0042476 | odontogenesis | biological process | ISS | |
GO:0030916 | otic vesicle formation | biological process | ISS | |
GO:0060667 | branch elongation involved in salivary gland morphogenesis | biological process | ISS | |
GO:0048755 | branching morphogenesis of a nerve | biological process | ISS | |
GO:0002053 | positive regulation of mesenchymal cell proliferation | biological process | ISS | |
GO:0005007 | fibroblast growth factor-activated receptor activity | molecular function | IDA[15629145]; IGI[10830168]; NAS[1400433] | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | ISS | |
GO:0030855 | epithelial cell differentiation | biological process | ISS | |
GO:0060449 | bud elongation involved in lung branching | biological process | ISS | |
GO:0009986 | cell surface | cellular component | IDA[16597614] | |
GO:0008284 | positive regulation of cell proliferation | biological process | IDA[8663044]; IGI[8663044]; IMP[15629145] | |
GO:0048286 | lung alveolus development | biological process | ISS | |
GO:0005886 | plasma membrane | cellular component | IDA; TAS | |
GO:0048562 | embryonic organ morphogenesis | biological process | ISS | |
GO:0001525 | angiogenesis | biological process | ISS | |
GO:0060349 | bone morphogenesis | biological process | ISS | |
GO:0048730 | epidermis morphogenesis | biological process | ISS | |
GO:0060916 | mesenchymal cell proliferation involved in lung development | biological process | ISS | |
GO:0035604 | fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow | biological process | ISS | |
GO:0003148 | outflow tract septum morphogenesis | biological process | ISS | |
GO:0031069 | hair follicle morphogenesis | biological process | ISS | |
GO:0060445 | branching involved in salivary gland morphogenesis | biological process | ISS | |
GO:0007409 | axonogenesis | biological process | ISS | |
GO:0035603 | fibroblast growth factor receptor signaling pathway involved in hemopoiesis | biological process | ISS | |
GO:0048568 | embryonic organ development | biological process | ISS | |
GO:0061031 | endodermal digestive tract morphogenesis | biological process | IEA | |
GO:0060615 | mammary gland bud formation | biological process | ISS | |
GO:0060915 | mesenchymal cell differentiation involved in lung development | biological process | ISS | |
GO:0060442 | branching involved in prostate gland morphogenesis | biological process | ISS | |
GO:0016021 | integral to membrane | cellular component | NAS[1697263] | |
GO:0021769 | orbitofrontal cortex development | biological process | ISS | |
GO:0004713 | protein tyrosine kinase activity | molecular function | NAS[1697263] | |
GO:0016331 | morphogenesis of embryonic epithelium | biological process | ISS | |
GO:0005794 | Golgi apparatus | cellular component | IEA | |
GO:0060512 | prostate gland morphogenesis | biological process | ISS |
Literature-origin KEGG pathway | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04810 | regulation of_actin_cytoskeleton | Regulation of actin cytoskeleton |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa05215 | prostate cancer | Prostate cancer | The identification of key molecular alterations in prostate-...... The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation. More... | |
hsa05200 | pathways in_cancer | Pathways in cancer | ||
hsa04010 | mapk signaling_pathway | MAPK signaling pathway | The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More... | |
hsa04144 | endocytosis | Endocytosis | Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_21272 | downstream signaling_of_activated_fgfr | Signaling via FGFRs is mediated via direct recruitment of si...... Signaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that become tyrosine phosphorylated in response to FGF-stimulation and form a complex with additional complement of signaling proteins. The activation loop in the catalytic domain of FGFR maintains the PTK domain in an inactive or low activity state. The activation-loop of FGFR1, for instance, contains two tyrosine residues that must be autophosphorylated for maintaining the catalytic domain in an active state. In the autoinhibited configuration, a kinase invariant proline residue at the C-terminal end of the activation loop interferes with substrate binding while allowing access to ATP in the nucleotidebinding site. Iin addition to the catalytic PTK core, the cytoplasmic domain of FGFR contains several regulatory sequences. The juxtamembrane domain of FGFRs is considerably longer than that of other receptor tyrosine kinases. This region contains a highly conserved sequence that serves as a binding site for the phosphotyrosine binding (PTB) domain of FRS2. A variety of signaling proteins are phosphorylated in response to FGF stimulation, including Shc, phospholipase-C gamma and FRS2 leading to stimulation of intracellular signaling pathways that control cell proliferation, cell differentiation, cell migration, cell survival and cell shape. More... | |
REACT_762 | irs related_events | IRS is one of the mediators of insulin signalling events. It...... IRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned under IRS are examples of IRS family members acting as indicated. More family members are to be confirmed and added in the future. More... | |
REACT_21310 | phospholipase cmediated_cascade | Phospholipase C-gamma (PLC-gamma) is a substrate of the fibr...... Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward tyrosine-autophosphorylated regions of the FGFR. PLC activation leads to phosphatidyl inositol (Pt Ins) hydrolysis, release of intracellular calcium and activation of PKC via recruitment of the SH2 domain of PLC-g to the FGFR. Activated PLC-gamma hydrolyzes Pt Ins P2 to form diacylglygerol (DAG) and Ins P3 which stimulates calcium release and activation of calcium/calmodulin dependent protein kinases. More... | |
REACT_21247 | frs2mediated cascade | FRS2 is an adapter protein that links FGFR receptors to down...... FRS2 is an adapter protein that links FGFR receptors to downstream MAP kinases. Depending on tissue expression, the products of two FRS2 genes, alpha and beta (the latter also known as FRS3, or SNT-2) serve as an essential core upon which a signaling complex consisting of the tyrosine phosphatase Shp2, the adaptor Grb2, and the docking protein GAB1 is formed, leading to the activation of the RAS-MAP kinase and PI-3-kinase/AKT pathways. More... | |
REACT_9396 | fgfr ligand_binding_and_activation | FGFs bind and activate alternatively spliced forms of four t...... FGFs bind and activate alternatively spliced forms of four tyrosine kinase FGF receptors in the region between the second and third immunoglobulin domain (known as D2 and D3). The first immunoglobulin domain (D1) and a stretch of acidic residues known as an acid box in the linker between D1 and D2 impart a lower affinity to FGFs compared to receptors in which such regions are removed. FGFRs also contain a short amino acid motif within the second immunoglobulin domain that shares sequence homology with functional motifs present in neural adhesion molecules such as NCAM and N-cadherin. This so called CAM homology domain (CHD) forms a contiguous sequence with the acid box region and is crucial for this mode of activation. Interactions between the neural cell adhesion molecules are important for a number of developmental events and have also been implicated in tumor progression. Although the interaction can be seen over most of the cell surface, it is not seen at points of cell-cell contact where the adhesion molecules accumulate at stable junctions. The FGFR interaction with N-cadherin and NCAM (but not FGF) is absolutely dependant on the presence of the acid box motif. As this motif can be spliced out of all four FGFRs, this suggests a mechanism that can regulate the interaction of the receptor with different ligand classes. From a hormonal point of view, the spatial and temporal expression patterns of FGFs and FGFRs and the ability of specific ligand-receptor pairs to actively signal are important factors regulating FGF activity in a variety of biological processes. FGF signaling activity is regulated by the binding specificity of ligands and receptors and is modulated by extrinsic cofactors such as heparan sulfate proteoglycans. More... | |
REACT_21270 | pi3k cascade | The ability of growth factors to protect from apoptosis is p...... The ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which in turn affects the activity or expression of pro-apoptotic factors, which contribute to protection from apoptosis. AKT activation also blocks the activity of GSK-3b which could lead to additional antiapoptotic signals. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
FGFR2 | EPHA4 | No | in vivo;yeast 2-hybrid | 16365308 | |
FGFR2 | FGF23 | No | in vitro | 12032146 | |
FGFR2 | FGF18 | No | in vitro | 10751172 | |
FGFR2 | ITGA5 | No | in vitro | 15728256 | |
FGFR2 | FGF17 | No | in vitro | 10751172 | |
FGFR2 | FGF10 | No | in vitro;in vivo | 9582367 | |
FGFR2 | FGF1 | Yes | in vitro;in vivo | 10618369 , 11069186 , 14732692 | |
FGFR2 | PTK2B | Yes | in vitro;in vivo | 15105428 | |
FGFR2 | PLCG1 | No | in vivo | 7999363 | |
FGFR2 | FGF9 | Yes | in vivo | 8576175 | |
FGFR2 | CACNA1D | No | in vivo | 11292657 | |
FGFR2 | FGF6 | No | in vitro | 8663044 | |
FGFR2 | FGF5 | No | in vivo | 11876253 | |
FGFR2 | FGF7 | No | in vivo | 7687739 | |
FGFR2 | FGF3 | No | in vitro | 8663044 | |
FGFR2 | FGF8 | No | in vitro | 8663044 , 10751172 | |
FGFR2 | FGF4 | No | in vitro | 8663044 | |
FGFR2 | PAK4 | No | in vitro;in vivo;yeast 2-hybrid | 12529371 |