KEGG Pathway Report
Basic Information
| ID |
hsa05215
|
| Name |
prostate cancer
|
| Brief Description |
Prostate cancer
|
| Full Description |
The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation. |
hsa05215 related genes in MK4MDD (count: 21)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| EP300 |
E1A binding protein p300 |
Literature-origin
|
1(1/0) |
| CCND1 |
cyclin D1 |
Literature-origin
|
1(1/0) |
| GSK3B |
glycogen synthase kinase 3 beta |
Literature-origin; SNP mapped; Protein mapped
|
7(6/1) |
| HSP90AB1 |
heat shock protein 90kDa alpha (cytosolic), class B member 1 |
Protein mapped
|
0(0/0) |
| CREBBP |
CREB binding protein |
Literature-origin
|
1(0/1) |
| FGFR2 |
fibroblast growth factor receptor 2 |
Literature-origin
|
2(2/0) |
| INS |
insulin |
Literature-origin; Protein mapped
|
1(1/0) |
| EGF |
epidermal growth factor |
Literature-origin; SNP mapped; Protein mapped
|
1(0/1) |
| CREB1 |
cAMP responsive element binding protein 1 |
Literature-origin; Protein mapped
|
12(10/2) |
| MTOR |
mechanistic target of rapamycin (serine/threonine kinase) |
Protein mapped
|
0(0/0) |
| NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
Protein mapped
|
0(0/0) |
| CREB3 |
cAMP responsive element binding protein 3 |
Literature-origin
|
1(1/0) |
| FGFR1 |
fibroblast growth factor receptor 1 |
Literature-origin
|
3(3/0) |
| PIK3R1 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Literature-origin
|
1(1/0) |
| CTNNB1 |
catenin (cadherin-associated protein), beta 1, 88kDa |
Protein mapped
|
0(0/0) |
| AR |
androgen receptor |
Literature-origin
|
3(3/0) |
| HSP90B1 |
heat shock protein 90kDa beta (Grp94), member 1 |
Protein mapped
|
0(0/0) |
| NFKB1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
Protein mapped
|
0(0/0) |
| MAPK1 |
mitogen-activated protein kinase 1 |
Literature-origin
|
2(2/0) |
| KRAS |
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
| HRAS |
v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
