MK4MDD

Gene Report

Basic Information
Approved Symbol CREB1
Approved Name cAMP responsive element binding protein 1
Location 2q34
Position chr2:208463804-208468155 (+)
External Links Entrez Gene: 1385
Ensembl: ENSG00000118260
UCSC: uc002vcc.3
HGNC ID: 2345
No. of Studies (Positive/Negative) 12(10/2) Help
Type Literature-origin; Protein mapped

Positive relationships between CREB1 and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
CREB1 Liu, 2010 patients and normal controls P-value=0.00003241 There was strong positive association between the rs10932201...... There was strong positive association between the rs10932201-rs6740584 haplotype of the CREB1 and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022) More...
cAMP-responsive element-binding protein (CREB) Zubenko, 2002 patients and normal controls The region between the markers that yielded the peak LOD sco...... The region between the markers that yielded the peak LOD score includes the CREB1 gene More...
CREB1 Zubenko, 2003 patients and normal controls P-value << 0.0001 The highest maximum LOD score observed, 8.19 (genome-wide a...... The highest maximum LOD score observed, 8.19 (genome-wide adjusted P << 0.0001), occurred for Recurrent Major Depressive Disorder (R-MDD) at D2S2321 (205 cM), located 121 kb proximal to CREB1 More...
CREB1 Maher, 2010 patients and normal controls The results continue to support sex-specific linkage of the ...... The results continue to support sex-specific linkage of the CREB1 region to mood disorders among women from families with RE-MDD. More...
CREB1 Zubenko, 2003 patients and normal controls Sequence variations in the CREB1 promoter and intron 8 have ...... Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders. More...
CREB Iga, 2007 patients and normal controls Levels of HDAC5 and CREB mRNA were significantly higher in d...... Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls More...
CREB1 Belzeaux, 2010 patients and normal controls We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More...

Positive relationships between CREB1 and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of CREB1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CREB1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
CREB1 Hettema JM, 2009 Patients and nomal controls None of these markers were significant in stage 2 in either ...... None of these markers were significant in stage 2 in either sex individually or combined More...
CREB1 Crisafulli C, 2012 patients and normal controls Participants were genotyped for 14 SNPs within CREB1, CREBBP...... Participants were genotyped for 14 SNPs within CREB1, CREBBP and CREM. We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. More...

Negative relationships between CREB1 and other components at different levels (count: 0) Help
CREB1 related SNPs in MK4MDD (count: 0)
CREB1 related proteins in MK4MDD (count: 1)
CREB1 related GO terms (count: 89)
CREB1 related KEGG pathways (count: 5)
CREB1 related BioCarta pathways (count: 11)
CREB1 related Reactome pathways (count: 23)
CREB1 related interactors from protein-protein interaction data in HPRD (count: 38)