MK4MDD

Gene Report

Basic Information
Approved Symbol GSK3B
Approved Name glycogen synthase kinase 3 beta
Location 3q13.3
Position chr3:119812282-119813264 (-)
External Links Entrez Gene: 2932
Ensembl: ENSG00000082701
UCSC: uc003edm.3
HGNC ID: 4617
No. of Studies (Positive/Negative) 7(6/1) Help
Type Literature-origin; Protein mapped

Positive relationships between GSK3B and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GSK3beta Inkster, 2010 patients and normal controls We observed associations for polymorphisms in 5/10 GSK3beta ...... We observed associations for polymorphisms in 5/10 GSK3beta substrate genes More...
GSK3B Zhang, 2010 patients and normal controls P-value<0.05 Further gene-gene interaction analyses showed a significant ...... Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019). More...
GSK3B Saus, 2010 patients and normal controls We identified a haplotype containing three SNPs (rs334555, r...... We identified a haplotype containing three SNPs (rs334555, rs119258668 and rs11927974) associated with age at onset (AAO) of the disorder (permutated P = 0.0025). More...
GSK3B Yang, 2010 patients and normal controls P-value=0.07 We observed a potential association between the GSK3B rs6782...... We observed a potential association between the GSK3B rs6782799 and MDD (P=0.07) More...
GSK-3beta Oh, 2010 patients and normal controls P-value<0.05 The level of GSK-3beta mRNA expression in the hippocampus wa...... The level of GSK-3beta mRNA expression in the hippocampus was significantly increased in the MDD group (n=8) compared with the control group (n=12, p<0.05). More...

Positive relationships between GSK3B and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of GSK3B in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GSK3B and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
GSK-3beta Yoon HK, 2010 Patients and nomal controls The results showed that the alleles, genotypes, and haploty...... The results showed that the alleles, genotypes, and haplotypes of the two SNPs do not differ between suicidal MDD subjects, non-suicidal MDD subjects, and normal controls. There was no difference in the haplotype frequency combination between the three groups. More...

Negative relationships between GSK3B and other components at different levels (count: 0) Help
GSK3B related SNPs in MK4MDD (count: 0)
GSK3B related proteins in MK4MDD (count: 1)
GSK3B related GO terms (count: 124)
GSK3B related KEGG pathways (count: 18)
GSK3B related BioCarta pathways (count: 12)
GSK3B related Reactome pathways (count: 9)
GSK3B related interactors from protein-protein interaction data in HPRD (count: 74)