Gene Report

Basic Information

Approved Symbol	DYNC1I1
Approved Name	dynein, cytoplasmic 1, intermediate chain 1
Previous Symbol	DNCI1
Previous Name	dynein, cytoplasmic, intermediate polypeptide 1
Symbol Alias	DNCIC1
Location	7q21.3-q22.1
Position	chr7:95401818-95727736 (+)
External Links	Entrez Gene: 1780 Ensembl: ENSG00000158560 UCSC: uc003uoc.4 HGNC ID: 2963
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between DYNC1I1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DYNC1I1	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between DYNC1I1 and other components at different levels (count: 0)

Positive relationship network of DYNC1I1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DYNC1I1 and MDD (count: 0)

Negative relationships between DYNC1I1 and other components at different levels (count: 0)

DYNC1I1 related SNPs in MK4MDD (count: 0)

DYNC1I1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cytoplasmic dynein 1 intermediate chain 1	O14576	1(1/0)	Literature-origin

DYNC1I1 related GO terms (count: 14)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0000776	kinetochore	cellular component	IDA[19229290]
GO:0047496	vesicle transport along microtubule	biological process	ISS
GO:0005515	protein binding	molecular function	IPI[14985359]
GO:0000922	spindle pole	cellular component	IDA[19229290]
GO:0005874	microtubule	cellular component	IEA
GO:0031982	vesicle	cellular component	IDA
GO:0003777	microtubule motor activity	molecular function	ISS
GO:0003774	motor activity	molecular function	TAS[10049579]
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0008017	microtubule binding	molecular function	ISS
GO:0005868	cytoplasmic dynein complex	cellular component	ISS
GO:0000777	condensed chromosome kinetochore	cellular component	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS

DYNC1I1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04962	vasopressin regulated_water_reabsorption	Vasopressin-regulated water reabsorption	In the kidney, the antidiuretic hormone vasopressin (AVP) is...... In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. More...

DYNC1I1 related BioCarta pathways (count: 0)

DYNC1I1 related Reactome pathways (count: 0)

DYNC1I1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DYNC1I1	BICD1	No	in vivo	17139249
DYNC1I1	DYNLT1	No	in vitro	8943288
DYNC1I1	DYNLL2	No	yeast 2-hybrid	16189514
DYNC1I1	GSK3B	Yes	in vivo	17139249
DYNC1I1	DYNLRB1	No	yeast 2-hybrid	16189514
DYNC1I1	DYNLL1	No	in vitro	11148209
DYNC1I1	STAU1	No	in vitro	15121898

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways