
Gene Report
Approved Symbol | YBX1 |
---|---|
Approved Name | Y box binding protein 1 |
Previous Symbol | NSEP1 |
Previous Name | nuclease sensitive element binding protein 1 |
Symbol Alias | YB-1, YB1, DBPB, NSEP-1, MDR-NF1, BP-8, CSDB, CSDA2 |
Location | 1p34 |
Position | chr1:43148066-43168020 (+) |
External Links |
Entrez Gene: 4904 Ensembl: ENSG00000065978 UCSC: uc001chs.3 HGNC ID: 8014 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
Y-box-binding protein 1 | Shelton, 2011 | patients and normal controls | The results strongly implicate increased apoptotic stress in...... The results strongly implicate increased apoptotic stress in the samples from the MDD group. Three anti-apoptotic factors, Y-box-binding protein 1, caspase-1 dominant-negative inhibitor pseudo-ICE, and the putative apoptosis inhibitor FKGS2, were over-expressed More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Nuclease-sensitive element-binding protein 1 | P67809 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0003723 | RNA binding | molecular function | IDA[19561594]; NAS | |
GO:0005689 | U12-type spliceosomal complex | cellular component | IDA[15146077] | |
GO:0008380 | RNA splicing | biological process | TAS | |
GO:0051154 | negative regulation of striated muscle cell differentiation | biological process | IEA | |
GO:0001701 | in utero embryonic development | biological process | IEA | |
GO:0010467 | gene expression | biological process | TAS | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular function | TAS[3174636] | |
GO:0003677 | DNA binding | molecular function | IDA[18809583]; TAS[8188694] | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological process | NAS | |
GO:0005634 | nucleus | cellular component | NAS | |
GO:0005515 | protein binding | molecular function | IPI[19174163] | |
GO:0070937 | CRD-mediated mRNA stability complex | cellular component | IDA[19029303] | |
GO:0003697 | single-stranded DNA binding | molecular function | IEA | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | IEA | |
GO:0003690 | double-stranded DNA binding | molecular function | TAS[1738588] | |
GO:0000398 | mRNA splicing, via spliceosome | biological process | TAS | |
GO:0043231 | intracellular membrane-bounded organelle | cellular component | IDA | |
GO:0005737 | cytoplasm | cellular component | IDA | |
GO:0030529 | ribonucleoprotein complex | cellular component | IDA[17289661] | |
GO:0005576 | extracellular region | cellular component | IEA | |
GO:0006355 | regulation of transcription, DNA-dependent | biological process | IDA[18809583]; NAS | |
GO:0006366 | transcription from RNA polymerase II promoter | biological process | TAS[3174636] | |
GO:0071204 | histone pre-mRNA 3'end processing complex | cellular component | ISS | |
GO:0010494 | cytoplasmic stress granule | cellular component | IDA[18335541] | |
GO:0051781 | positive regulation of cell division | biological process | IEA | |
GO:0070934 | CRD-mediated mRNA stabilization | biological process | IMP[19029303] | |
GO:0005654 | nucleoplasm | cellular component | TAS |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_125 | processing of_capped_intron_containing_pre_mrna | Any covalent change in a primary (nascent) mRNA transcript i...... Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm. More... | |
REACT_1021 | elongation and_processing_of_capped_transcripts | ||
REACT_2039 | formation and_maturation_of_mrna_transcript | Before a gene transcript is ready to be transported out of t...... Before a gene transcript is ready to be transported out of the nucleus, it has to undergo three major processing events to produce a fully translatable mRNA. These comprise capping, splicing out of introns from within the body of the pre-mRNA, and the generation of a 3' end, by cleavage, and except in the case of histone pre-mRNAs, polyadenylation. Although each of these reactions is a biochemically distinct process, these processes are interlinked and hence, influence one another's specificity and efficiency. On the other hand, most mRNA processing reactions occur co-transcriptionally. This is particularly important in very long genes where a strictly post-transcriptional processing would imply the existence of extremely long primary transcript molecules that would be susceptible to degradation. The co-transcriptional nature of pre-mRNA processing does not necessarily imply a functional coupling between the transcription and mRNA processing machineries. In some cases it may simply reflect that processing reactions occur during transcription because they are relatively fast compared with the time it takes to transcribe a gene to its end. In other cases a tight link exists between a particular processing reaction and the transcription process, due to the ability of the carboxy-terminal (CTD) of RNA polymerase II largest subunit to bind or recruit processing factors. The CTD consists of 52 heptad repeats (YSPTSPS). Specific phosphorylation/dephosphorylation patterns of serines 2 and 5 are critical for CTD function in coupling. CTD deletions that do not inactivate transcription significantly decrease the efficiency of capping, splicing and polyadenylation. The export of mRNA from the nucleus and mRNA splicing are also coupled. Mature mRNAs generated by splicing are more efficiently exported than their identical counterparts transcribed from a complementary DNA (cDNA). This effect of splicing on export is due to the recruitment of the mRNA export factor ALY to the mRNA during the splicing reaction, which in turn delivers the mRNP to the nuclear pore for export. More... | |
REACT_71 | gene expression | Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More... | |
REACT_1735 | mrna splicing | The process in which excision of introns from the primary tr...... The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
YBX1 | FUS | No | in vitro;yeast 2-hybrid | 12168660 | |
YBX1 | SFRS12 | No | in vitro;in vivo;yeast 2-hybrid | 14559993 | |
YBX1 | SMAD3 | No | in vitro;in vivo | 12917425 | |
YBX1 | HABP4 | No | yeast 2-hybrid | 16455055 | |
YBX1 | PCBP2 | Yes | yeast 2-hybrid | 8871564 | |
YBX1 | MAPK1 | Yes | in vitro | 16198352 | |
YBX1 | HNRNPD | No | in vitro;in vivo;yeast 2-hybrid | 12674497 | |
YBX1 | FBXO33 | No | in vitro;in vivo | 16797541 | |
YBX1 | AKT1 | No | in vitro;in vivo | 16354698 | |
YBX1 | TFAP2A | No | in vitro;in vivo | 9830047 , 11973333 | |
YBX1 | IREB2 | No | in vitro;in vivo;yeast 2-hybrid | 12192037 | |
YBX1 | RBBP6 | No | in vitro;in vivo;yeast 2-hybrid | 18851979 | |
YBX1 | SFRS9 | No | in vivo;yeast 2-hybrid | 12604611 | |
YBX1 | FMR1 | No | in vivo | 11162447 | |
YBX1 | PURA | No | in vitro;in vivo | 10318844 , 11751932 | |
YBX1 | YBX1 | Yes | in vitro;in vivo;yeast 2-hybrid | 12192037 | |
YBX1 | TP53 | No | in vitro;in vivo | 11175333 , 11973333 | |
YBX1 | NFYB | No | in vitro | 7651426 | |
YBX1 | CTCF | No | in vitro;in vivo | 10906122 , 15229244 | |
YBX1 | HNRNPK | No | in vitro;in vivo;yeast 2-hybrid | 10809782 | |
YBX1 | GSK3B | Yes | in vitro | 16198352 | |
YBX1 | VEGFA | Yes | in vitro | 16198352 | |
YBX1 | ANKRD2 | No | in vitro;in vivo | 15136035 | |
YBX1 | SLC6A4 | Yes | in vitro;in vivo;yeast 2-hybrid | 15229244 | |
YBX1 | PCNA | No | in vitro;in vivo | 9927044 |