Gene Report

Basic Information

Approved Symbol	CREM
Approved Name	cAMP responsive element modulator
Symbol Alias	hCREM-2
Location	10p12.1-p11.1
Position	chr10:35500732-35501886 (+)
External Links	Entrez Gene: 1390 Ensembl: ENSG00000095794 UCSC: uc001iyb.3 HGNC ID: 2352
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between CREM and MDD (count: 0)

Positive relationships between CREM and other components at different levels (count: 0)

Positive relationship network of CREM in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CREM and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CREM	Crisafulli C, 2012	patients and normal controls		Participants were genotyped for 14 SNPs within CREB1, CREBBP...... Participants were genotyped for 14 SNPs within CREB1, CREBBP and CREM. We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. More...

Negative relationships between CREM and other components at different levels (count: 0)

CREM related SNPs in MK4MDD (count: 0)

CREM related proteins in MK4MDD (count: 0)

CREM related GO terms (count: 23)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0007165	signal transduction	biological process	TAS[7916662]
GO:0032922	circadian regulation of gene expression	biological process	IEA
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[8206879]; NAS[7916662]
GO:0005667	transcription factor complex	cellular component	IEA
GO:0042752	regulation of circadian rhythm	biological process	IEA
GO:0003677	DNA binding	molecular function	NAS[7916662]
GO:0007275	multicellular organism development	biological process	IEA
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IEA
GO:0007283	spermatogenesis	biological process	IEA
GO:0005737	cytoplasm	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI[10373550\|21976679]
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0006006	glucose metabolic process	biological process	IEA
GO:0006687	glycosphingolipid metabolic process	biological process	IEA
GO:0048384	retinoic acid receptor signaling pathway	biological process	IEA
GO:0030154	cell differentiation	biological process	IEA
GO:0005634	nucleus	cellular component	NAS[8206879]
GO:0051591	response to cAMP	biological process	IEA
GO:0008140	cAMP response element binding protein binding	molecular function	NAS[8206879]
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IEA
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IEA
GO:0006631	fatty acid metabolic process	biological process	IEA

CREM related KEGG pathways (count: 0)

CREM related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
DREAM_PATHWAY	dream pathway	Repression of Pain Sensation by the Transcriptional Regulator DREAM	The molecular events that lead to the perception of pain are...... The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain signaling in response to endogenous peptide ligands and opiate drugs such as morphine. The kappa opioid receptor plays a key role in the profound analgesia of opiates and is activated by the endogenous peptide ligand dynorphin, encoded by the prodynorphin gene. Production of prodynorphin is transcriptionally regulated by a downstream regulatory element (DRE) in the prodynorphin gene. A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound. DREAM binds calcium with 4 EF-hand motifs and the binding of DREAM to DNA is repressed in the presence of calcium. Many transcription factors are regulated by calcium indirectly through calcium sensitive kinases and phosphatases, but DREAM is unique to date in being a transcription factor that directly binds calcium and is regulated by calcium binding. DREAM may also regulate other genes such as c-fos. DREAM is expressed in spinal cord neurons in regions involved in pain signaling. The regulation of prodynorphin expression by DREAM also leads to the hypothesis that DREAM is involved in pain signaling. Transgenic mice lacking the DREAM gene were unusually pain insensitive and had elevated spinal levels of dynorphin and tonic activation of the kappa opioid receptor, supporting this hypothesis. Other functions of DREAM may exist such as regulation of presenilins and potassium channel activity in the heart. DREAM is also known as calsenilin and KChIP3 through its association with these other proteins. These processes were not affected in mice lacking the DREAM gene however. More...

CREM related Reactome pathways (count: 0)

CREM related interactors from protein-protein interaction data in HPRD (count: 21)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CREM	CSNK2A2	No	in vitro;in vivo	8404858
CREM	SPI1	Yes	in vitro	7730336
CREM	CAMK2G	No	in vitro;in vivo	8404858
CREM	CREB1	Yes	in vitro;in vivo	7809053
CREM	PRKCA	No	in vitro;in vivo	8404858
CREM	TBP	No	in vitro	10409662
CREM	ATF1	No	in vitro	12805554
CREM	GSK3A	No	in vitro;in vivo	8404858
CREM	CDC34	No	in vivo;yeast 2-hybrid	10373550
CREM	KCNIP3	No	in vitro	11094064 , 12198160
CREM	GSK3B	Yes	in vitro;in vivo	8404858
CREM	CSNK2A1	Yes	in vitro;in vivo	8404858
CREM	CREBBP	Yes	in vitro;in vivo	9006899
CREM	CDK1	No	in vitro;in vivo	8404858
CREM	CAMK2D	No	in vitro;in vivo	8404858
CREM	PRKACA	No	in vitro;in vivo	8404858
CREM	CREM	Yes	in vitro	8994192
CREM	CSNK1A1	No	in vitro;in vivo	8404858
CREM	CREB3L1	No	in vitro	12805554
CREM	TAF4	No	in vitro	10409662
CREM	FHL5	No	in vitro;in vivo;yeast 2-hybrid	10086359

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways