Gene Report

Basic Information

Approved Symbol	RAB1A
Approved Name	RAB1A, member RAS oncogene family
Previous Symbol	RAB1
Symbol Alias	YPT1
Name Alias	"Rab GTPase YPT1 homolog (yeast)"
Location	2p14
Position	chr2:65357050-65357240 (-)
External Links	Entrez Gene: 5861 Ensembl: ENSG00000138069 UCSC: uc002sdm.3 HGNC ID: 9758
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAB1A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAB1A	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between RAB1A and other components at different levels (count: 0)

Positive relationship network of RAB1A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAB1A and MDD (count: 0)

Negative relationships between RAB1A and other components at different levels (count: 0)

RAB1A related SNPs in MK4MDD (count: 0)

RAB1A related proteins in MK4MDD (count: 0)

RAB1A related GO terms (count: 39)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0047496	vesicle transport along microtubule	biological process	IMP[21303926]
GO:0016192	vesicle-mediated transport	biological process	TAS[2501306]
GO:0090557	establishment of endothelial intestinal barrier	biological process	IMP[23885123]
GO:0005829	cytosol	cellular component	TAS
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005789	endoplasmic reticulum membrane	cellular component	IBA
GO:1903020	positive regulation of glycoprotein metabolic process	biological process	IGI[21680502]
GO:0006914	autophagy	biological process	IMP[22939626]
GO:0000278	mitotic cell cycle	biological process	TAS
GO:0003924	GTPase activity	molecular function	IDA[17684057\|22939626]
GO:0005515	protein binding	molecular function	IPI[15186776\|15796781\|16902405\|17684057\|19942850\|25446900\|26496610]
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0005769	early endosome	cellular component	IEA
GO:0042384	cilium assembly	biological process	IMP[17646400]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0030252	growth hormone secretion	biological process	IMP[22939626]
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS
GO:0005525	GTP binding	molecular function	IEA
GO:0034446	substrate adhesion-dependent cell spreading	biological process	IEA
GO:0042470	melanosome	cellular component	IEA
GO:0043687	post-translational protein modification	biological process	TAS
GO:0061024	membrane organization	biological process	TAS
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	IGI[21680502]; IMP[17684057\|21680502\|22939626]; TAS
GO:0070062	extracellular exosome	cellular component	IDA[20458337]
GO:0016477	cell migration	biological process	IMP[20639577]
GO:0005794	Golgi apparatus	cellular component	IDA[16791210]
GO:0007264	small GTPase mediated signal transduction	biological process	IEA
GO:0000139	Golgi membrane	cellular component	IBA; TAS
GO:0072606	interleukin-8 secretion	biological process	IMP[22939626]
GO:0090110	cargo loading into COPII-coated vesicle	biological process	IMP[17684057]
GO:0032402	melanosome transport	biological process	IEA
GO:0019068	virion assembly	biological process	IGI[21680502]; IMP[21680502]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0042742	defense response to bacterium	biological process	IMP[22939626]
GO:0006897	endocytosis	biological process	IMP[21303926]
GO:0048208	COPII vesicle coating	biological process	TAS
GO:0000045	autophagosome assembly	biological process	IMP[22939626]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0007030	Golgi organization	biological process	IMP[17684057]

RAB1A related KEGG pathways (count: 0)

RAB1A related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
RAB_PATHWAY	rab pathway	Rab GTPases Mark Targets In The Endocytotic Machinery	The eukaryotic cell contains compartments with distinct func...... The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes. The movement of membrane vesicles between these compartments allows proteins in the secretory pathway to move outward from the endoplasmic reticulum (ER) to the Golgi, trans Golgi network (TGN), secretory vesicles, and the plasma membrane and to be secreted into the extracellular environment. The trafficking of membrane vesicles is also essential for endocytosis and the movement of material from the extracellular environment into the early endosome (EE), late endosome (LE) and lysosome. The movement of vesicles and their contents between these compartments and their secretion are essential for a host of cellular functions, including the release of neurotransmitters and hormones. The movement of membrane vesicles between all of these compartments is regulated by members of the Rab family of GTPases, part of the ras superfamily of genes, regulated through binding of GTP and hydrolysis of bound GTP to GDP. At least eleven yeast genes in this family have been identified as Ypts, yeast transport proteins, and over sixty mammalian Rab genes have been identified in this highly conserved gene family. The products of the Rab genes regulate specific steps in vesicle transport. Rab1 is involved in the movement of membranes from the ER through the Golgi. Rab3 regulates secretory vesicle release and Rab27 is also involved in regulated release of secreted proteins. Rab5, 7 and 9 contribute to endocytosis while Rab4 and Rab11 mediate recycling from the endosome back to the plasma membrane. Rab11 is involved in both endocytosis and exocytosis. As with other Ras family GTPases, the activity of Rabs is regulated by guanine-nucleotide exchange factors (GEFs) and GAPs (GTPase activating proteins). Downstream effectors must also interact with Rabs to transmit their signals regulating each step of the membrane trafficking pathways including vesicle formation, movement of vesicles between compartments, vesicle docking, fusion and membrane remodeling. Downstream effectors of the Rabs include Rabphilin-3 (vesicle movement effector for Rab3), Rabphilin-11 (vesicle formation effector for Rab11), and EEA1 (vesicle fusion and membrane remodeling). If Rabs are involved in more than one role and other components of Rab signaling also interact with more than one Rab this will further increase the complexity of the system. Elucidating the interaction of Rabs and regulation of vesicle trafficking by other signaling pathways will be a key area of research in the future. More...

RAB1A related Reactome pathways (count: 0)

RAB1A related interactors from protein-protein interaction data in HPRD (count: 23)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAB1A	OCRL	No	in vitro;in vivo;yeast 2-hybrid	16902405
RAB1A	RABGGTA	No	in vitro	7991565
RAB1A	RABAC1	No	yeast 2-hybrid	9341137
RAB1A	TBC1D17	No	yeast 2-hybrid	16169070
RAB1A	CREB1	Yes	yeast 2-hybrid	16169070
RAB1A	PSMD7	No	yeast 2-hybrid	16169070
RAB1A	MAPRE3	No	yeast 2-hybrid	16169070
RAB1A	SLC16A8	No	yeast 2-hybrid	16169070
RAB1A	HIVEP1	No	yeast 2-hybrid	16169070
RAB1A	CHML	No	in vitro	9730828 , 8294464
RAB1A	USO1	No	in vitro;in vivo;yeast 2-hybrid	10903204 , 16473624
RAB1A	ZNF593	No	yeast 2-hybrid	16169070
RAB1A	CDKN1A	No	yeast 2-hybrid	16169070
RAB1A	FSCN1	No	yeast 2-hybrid	16169070
RAB1A	MICALL1	No	in vitro;in vivo;yeast 2-hybrid	12788069
RAB1A	GORASP2	No	in vivo	11739401
RAB1A	GOLGA5	No	in vitro;in vivo;yeast 2-hybrid	12656988 , 12538640
RAB1A	GOLGA2	Yes	in vitro;yeast 2-hybrid	11739401
RAB1A	RFK	No	yeast 2-hybrid	16169070
RAB1A	SYT5	No	yeast 2-hybrid	16169070
RAB1A	RABGGTB	No	in vitro	7991565
RAB1A	CAPNS1	No	yeast 2-hybrid	16169070
RAB1A	ADCK1	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways