Gene Report

Basic Information

Approved Symbol	THRA
Approved Name	thyroid hormone receptor, alpha
Previous Symbol	THRA1, THRA2, ERBA1
Previous Name	"thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog)", "thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)"
Symbol Alias	EAR-7.1/EAR-7.2, THRA3, AR7, ERBA, NR1A1
Location	17q21.1
Position	chr17:38249636-38250120 (+)
External Links	Entrez Gene: 7067 Ensembl: ENSG00000126351 UCSC: uc002htw.3 HGNC ID: 11796
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between THRA and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Thyroid hormone receptor, alpha	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between THRA and other components at different levels (count: 0)

Positive relationship network of THRA in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between THRA and MDD (count: 0)

Negative relationships between THRA and other components at different levels (count: 0)

THRA related SNPs in MK4MDD (count: 0)

THRA related proteins in MK4MDD (count: 0)

THRA related GO terms (count: 57)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[8710870]
GO:0048568	embryonic organ development	biological process	IEA
GO:0005739	mitochondrion	cellular component	IEA
GO:0050994	regulation of lipid catabolic process	biological process	IEA
GO:0042994	cytoplasmic sequestering of transcription factor	biological process	IEA
GO:0010467	gene expression	biological process	TAS
GO:0030218	erythrocyte differentiation	biological process	IEA
GO:0042493	response to drug	biological process	IEA
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[8710870\|9653119]
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[18052923]
GO:0030325	adrenal gland development	biological process	IEA
GO:0002153	steroid receptor RNA activator RNA binding	molecular function	IEA
GO:0045925	positive regulation of female receptivity	biological process	IEA
GO:0001889	liver development	biological process	IEA
GO:0033032	regulation of myeloid cell apoptotic process	biological process	IEA
GO:0003707	steroid hormone receptor activity	molecular function	IEA
GO:0009755	hormone-mediated signaling pathway	biological process	IDA[18052923]
GO:0017025	TBP-class protein binding	molecular function	IDA[8524305]
GO:0007420	brain development	biological process	IEA
GO:0032403	protein complex binding	molecular function	IEA
GO:0008134	transcription factor binding	molecular function	IPI[8524305]
GO:0019904	protein domain specific binding	molecular function	IPI[9653119]
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[18052923]
GO:0008050	female courtship behavior	biological process	IEA
GO:0005829	cytosol	cellular component	IDA[19158403]
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:2000143	negative regulation of DNA-templated transcription, initiation	biological process	IDA[8524305]
GO:0031667	response to nutrient levels	biological process	IEA
GO:0043565	sequence-specific DNA binding	molecular function	IEA
GO:0031490	chromatin DNA binding	molecular function	IEA
GO:0060509	Type I pneumocyte differentiation	biological process	IEA
GO:0030878	thyroid gland development	biological process	IEA
GO:0001503	ossification	biological process	IEA
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IDA[8710870\|9653119\|18052923]
GO:0001502	cartilage condensation	biological process	IEA
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular function	IEA
GO:0048565	digestive tract development	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[8710870\|19158403]
GO:0004887	thyroid hormone receptor activity	molecular function	IDA[8710870\|15466465\|18052923]
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	biological process	IDA[8524305]
GO:0001822	kidney development	biological process	IEA
GO:0070324	thyroid hormone binding	molecular function	IDA[8710870\|15466465]; IPI[2879243]
GO:0009409	response to cold	biological process	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS
GO:0030522	intracellular receptor signaling pathway	biological process	IDA[8710870\|15466465\|18052923]; IEA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0043401	steroid hormone mediated signaling pathway	biological process	IEA
GO:0010831	positive regulation of myotube differentiation	biological process	IEA
GO:0042803	protein homodimerization activity	molecular function	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0044213	intronic transcription regulatory region DNA binding	molecular function	IEA
GO:0007611	learning or memory	biological process	IEA
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[9653119\|10866662\|16799563\|25416956]
GO:0002155	regulation of thyroid hormone mediated signaling pathway	biological process	IEA
GO:0008016	regulation of heart contraction	biological process	IEA

THRA related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

THRA related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
EGFR_SMRTE_PATHWAY	egfr smrte_pathway	Map Kinase Inactivation of SMRT Corepressor	Corepressors are coregulators that interact with transcripti...... Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is shown in this diagram. The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by each pathway is shown, causing SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. More...

THRA related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15525	nuclear receptor_transcription_pathway	A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More...
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...

THRA related interactors from protein-protein interaction data in HPRD (count: 33)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
THRA	TDG	No	in vitro	12874288
THRA	SLC16A2	Yes	in vitro;in vivo	12871948
THRA	MED21	No	in vitro;yeast 2-hybrid	15249124
THRA	YWHAH	No	in vitro	11266503
THRA	FUS	No	in vitro	9440806
THRA	CCND1	Yes	in vivo	12048199
THRA	NCOA6	No	in vitro;yeast 2-hybrid	10866662 , 11158331
THRA	CDK7	No	yeast 2-hybrid	15249124
THRA	HDAC2	Yes	in vitro	10508171
THRA	COPS2	No	in vitro;in vivo;yeast 2-hybrid	10207062
THRA	CREBBP	Yes	in vitro;in vivo	8616895
THRA	GTF2B	No	in vitro	7609079
THRA	MED1	No	in vitro;in vivo	9653119
THRA	ESR1	Yes	in vitro;yeast 2-hybrid	9717844
THRA	NR2F1	No	in vitro	1331778
THRA	RGN	No	yeast 2-hybrid	15604093
THRA	PML	No	in vivo	10610177
THRA	NCOR1	No	yeast 2-hybrid	15604093
THRA	BTG1	Yes	in vitro;in vivo	15674337
THRA	POU2F1	No	in vivo	10480874
THRA	CREB1	Yes	in vitro;in vivo	12805224
THRA	MEF2A	No	in vivo	12371907
THRA	AKAP13	No	in vitro;in vivo	9627117
THRA	TRIM24	No	in vivo	9115274
THRA	NCOR2	No	in vivo;yeast 2-hybrid	7566127
THRA	NSD1	No	in vitro	9628876
THRA	RXRA	Yes	in vitro;yeast 2-hybrid	1331778 , 15604093
THRA	CUL1	No	yeast 2-hybrid	15604093
THRA	NCOA1	No	in vitro	15249124
THRA	OASL	No	yeast 2-hybrid	7776974
THRA	SRC	No	in vitro	15140878
THRA	RXRB	No	in vitro	1331778
THRA	RXRG	No	in vitro	8127707

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways

Gene mapped Reactome pathways