Gene Report

Basic Information

Approved Symbol	SLC16A2
Approved Name	solute carrier family 16, member 2 (thyroid hormone transporter)
Previous Symbol	DXS128, AHDS, MRX22
Previous Name	solute carrier family 16 (monocarboxylic acid transporters), member 2 (putative transporter), "Allan-Herndon-Dudley syndrome", "solute carrier family 16 (monocarboxylic acid transporters), member 2", "mental retardation, X-linked 22", "solute carrier family 16, member 2 (monocarboxylic acid transporter 8)"
Symbol Alias	XPCT, MCT8, MCT7
Location	Xq13.2
Position	chrX:73641328-73753764 (+)
External Links	Entrez Gene: 6567 Ensembl: ENSG00000147100 UCSC: uc004ebt.2 HGNC ID: 10923
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SLC16A2 and MDD (count: 0)

Positive relationships between SLC16A2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
thyroid hormone transporter gene		left occipital cortex(left occipital cortex)	brain morphology and function	Dixson, 2011	patients and normal controls	P-value<0.01	group-by-genotype interactions for two in two thyroid hormon...... group-by-genotype interactions for two in two thyroid hormone transporter genes highly correlated SNPs (rs496549 and rs479640) revealed co-localised association clusters in the left occipital cortex (P-values 0.002 and 0.004, respectively, after full correction for whole brain and multiple SNP testing) More...

Positive relationship network of SLC16A2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC16A2 and MDD (count: 0)

Negative relationships between SLC16A2 and other components at different levels (count: 0)

SLC16A2 related SNPs in MK4MDD (count: 0)

SLC16A2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Monocarboxylate transporter 8	P36021	0(0/0)	Gene mapped

SLC16A2 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005887	integral to plasma membrane	cellular component	TAS[9425115]
GO:0016020	membrane	cellular component	TAS[9425115]
GO:0015718	monocarboxylic acid transport	biological process	TAS[9425115]
GO:0006810	transport	biological process	TAS[7981683]
GO:0008028	monocarboxylic acid transmembrane transporter activity	molecular function	TAS[9425115]
GO:0005215	transporter activity	molecular function	TAS[7981683]
GO:0015293	symporter activity	molecular function	IEA

SLC16A2 related KEGG pathways (count: 0)

SLC16A2 related BioCarta pathways (count: 0)

SLC16A2 related Reactome pathways (count: 0)

SLC16A2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SLC16A2	SERPINA7	No	in vitro;in vivo	12871948
SLC16A2	THRA	Yes	in vitro;in vivo	12871948

Gene Report

Gene mapped GO terms