Reactome Pathway Report
Basic Information
ID |
|
Name |
nuclear receptor_transcription_pathway
|
Description |
A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1.
|
REACT_15525 related genes in MK4MDD (count: 8)
Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
THRA |
thyroid hormone receptor, alpha |
Literature-origin
|
1(1/0) |
RORC |
RAR-related orphan receptor C |
Literature-origin
|
1(1/0) |
NR4A2 |
nuclear receptor subfamily 4, group A, member 2 |
Literature-origin
|
1(1/0) |
AR |
androgen receptor |
Literature-origin
|
3(3/0) |
NR1D1 |
nuclear receptor subfamily 1, group D, member 1 |
Literature-origin
|
1(0/1) |
NR3C1 |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
Literature-origin; SNP mapped; Protein mapped
|
7(7/0) |
ESR1 |
estrogen receptor 1 |
Literature-origin; SNP mapped
|
3(3/0) |
NR3C2 |
nuclear receptor subfamily 3, group C, member 2 |
Literature-origin; SNP mapped
|
3(3/0) |