MK4MDD

Reactome Pathway Report

Basic Information
ID
Name nuclear receptor_transcription_pathway
Description A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1.

REACT_15525 related genes in MK4MDD (count: 8)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
THRA thyroid hormone receptor, alpha Literature-origin 1(1/0)
RORC RAR-related orphan receptor C Literature-origin 1(1/0)
NR4A2 nuclear receptor subfamily 4, group A, member 2 Literature-origin 1(1/0)
AR androgen receptor Literature-origin 3(3/0)
NR1D1 nuclear receptor subfamily 1, group D, member 1 Literature-origin 1(0/1)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Literature-origin; SNP mapped; Protein mapped 7(7/0)
ESR1 estrogen receptor 1 Literature-origin; SNP mapped 3(3/0)
NR3C2 nuclear receptor subfamily 3, group C, member 2 Literature-origin; SNP mapped 3(3/0)