Gene Report

Basic Information

Approved Symbol	BTG1
Approved Name	B-cell translocation gene 1, anti-proliferative
Location	12q21.33
Position	chr12:92539312-92539673 (-)
External Links	Entrez Gene: 694 Ensembl: ENSG00000133639 UCSC: uc001tby.3 HGNC ID: 1130
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BTG1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
B-cell translocation protein 1	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between BTG1 and other components at different levels (count: 0)

Positive relationship network of BTG1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BTG1 and MDD (count: 0)

Negative relationships between BTG1 and other components at different levels (count: 0)

BTG1 related SNPs in MK4MDD (count: 0)

BTG1 related proteins in MK4MDD (count: 0)

BTG1 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006479	protein methylation	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[9712883\|9820826\|10617598\|11136725\|16189514\|21900206]
GO:0045603	positive regulation of endothelial cell differentiation	biological process	IMP[15033446]
GO:0006979	response to oxidative stress	biological process	IEA
GO:0043434	response to peptide hormone	biological process	IEA
GO:0019899	enzyme binding	molecular function	IPI[8663146]
GO:0045766	positive regulation of angiogenesis	biological process	IMP[15033446]
GO:0019900	kinase binding	molecular function	NAS[9820826]
GO:0030308	negative regulation of cell growth	biological process	NAS[15033446]
GO:0005737	cytoplasm	cellular component	IDA[11420681]; IMP[11420681]
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[11420681]
GO:0005634	nucleus	cellular component	IDA[9820826\|11420681]; IMP[11420681]
GO:0045663	positive regulation of myoblast differentiation	biological process	IDA[11420681]; NAS[15033446]
GO:0008285	negative regulation of cell proliferation	biological process	IDA[1373383\|11420681]
GO:2000271	positive regulation of fibroblast apoptotic process	biological process	IMP[9690562]
GO:0003712	transcription cofactor activity	molecular function	NAS[11420681]
GO:0007283	spermatogenesis	biological process	IEA
GO:0016477	cell migration	biological process	NAS[15033446]

BTG1 related KEGG pathways (count: 0)

BTG1 related BioCarta pathways (count: 0)

BTG1 related Reactome pathways (count: 0)

BTG1 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BTG1	THRA	Yes	in vitro;in vivo	15674337
BTG1	THRB	No	in vitro	15674337
BTG1	RARA	No	in vitro	15674337
BTG1	HOXB9	No	in vitro;yeast 2-hybrid	10617598
BTG1	PRMT1	No	in vitro;yeast 2-hybrid	14734530 , 8663146 , 11856371
BTG1	CCNA2	No	in vitro	9820826
BTG1	CNOT7	No	in vitro;in vivo	9820826 , 11136725 , 11429045
BTG1	CNOT8	No	in vitro	11136725

Gene Report

Literature-origin GO terms

Gene mapped GO terms