Gene Report
Approved Symbol | ESR1 |
---|---|
Approved Name | estrogen receptor 1 |
Previous Symbol | ESR |
Symbol Alias | NR3A1, Era |
Location | 6q24-q27 |
Position | chr6:152011631-152424409 (+) |
External Links |
Entrez Gene: 2099 Ensembl: ENSG00000091831 UCSC: uc003qon.4 HGNC ID: 3467 |
No. of Studies (Positive/Negative) | 3(3/0) |
Type | Literature-origin; SNP mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | |
---|---|---|---|---|---|
ER-alpha | Tsai, 2003 | patients and normal controls | P-value<0.05 | Statistical analysis showed a significant difference in the ...... Statistical analysis showed a significant difference in the II genotype and allele frequencies between the female MDD patients and the female controls ( P=0.010 and P=0.004, respectively). More... | |
ER | Geng, 2007 | patients and normal controls | AR gene in MDD group have shorter microsatellites' length, a...... AR gene in MDD group have shorter microsatellites' length, and ER beta gene have shorter microsatellites' length and higher rates of S alleles, SS, genotype, and lower rate of LL genotype than control group. More... | ||
ESR1 | Ryan J, 2012 | nomal people | P-value=0.009 | Women homozygous for the variant G allele of ESR1 rs9340799 ...... Women homozygous for the variant G allele of ESR1 rs9340799 had a 1.6-fold increased risk of MDD across their lifetime compared with women who were homozygous for the A allele (p=0.009) More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
#rs | Location | Annotation | No. of Studies (Positive/Negative) | |
---|---|---|---|---|
rs2234693 | chr6:152163335(Forward) | intron_variant | 1(1/0) | |
rs9340799 | chr6:152163381(Forward) | intron_variant | 2(2/0) |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Estrogen receptor | P03372 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | biological process | IDA[10681512] | |
GO:0048386 | positive regulation of retinoic acid receptor signaling pathway | biological process | IDA[15831516] | |
GO:0060523 | prostate epithelial cord elongation | biological process | IEA | |
GO:0008209 | androgen metabolic process | biological process | IEA | |
GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation | biological process | IEA | |
GO:0043627 | response to estrogen stimulus | biological process | IDA[11581164] | |
GO:0005886 | plasma membrane | cellular component | IDA[15569929] | |
GO:0060749 | mammary gland alveolus development | biological process | IEA | |
GO:0005654 | nucleoplasm | cellular component | TAS | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | IDA[15345745] | |
GO:0038052 | estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | molecular function | IGI[18722177] | |
GO:0042981 | regulation of apoptotic process | biological process | IEA | |
GO:0060745 | mammary gland branching involved in pregnancy | biological process | IEA | |
GO:0060068 | vagina development | biological process | IEA | |
GO:0006355 | regulation of transcription, DNA-dependent | biological process | NAS[3753802] | |
GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB cascade | biological process | IDA[16043358] | |
GO:0042802 | identical protein binding | molecular function | IPI | |
GO:0010467 | gene expression | biological process | TAS | |
GO:0006351 | transcription, DNA-dependent | biological process | TAS[2040605] | |
GO:0005634 | nucleus | cellular component | IDA[15569929] | |
GO:0003682 | chromatin binding | molecular function | IEA | |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | biological process | IDA[10816575] | |
GO:0030520 | intracellular estrogen receptor signaling pathway | biological process | NAS[3753802] | |
GO:0019899 | enzyme binding | molecular function | IPI[12039952] | |
GO:0001547 | antral ovarian follicle growth | biological process | IEA | |
GO:0008134 | transcription factor binding | molecular function | IEA | |
GO:0002064 | epithelial cell development | biological process | IEA | |
GO:0030235 | nitric-oxide synthase regulator activity | molecular function | NAS[12389206] | |
GO:0005496 | steroid binding | molecular function | IEA | |
GO:0001046 | core promoter sequence-specific DNA binding | molecular function | IDA[15345745] | |
GO:0006367 | transcription initiation from RNA polymerase II promoter | biological process | TAS | |
GO:0051000 | positive regulation of nitric-oxide synthase activity | biological process | IDA | |
GO:0060527 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | biological process | IEA | |
GO:0005794 | Golgi apparatus | cellular component | IEA | |
GO:0010629 | negative regulation of gene expression | biological process | IDA | |
GO:0016020 | membrane | cellular component | NAS[11960618] | |
GO:0007165 | signal transduction | biological process | TAS[10749889] | |
GO:0008013 | beta-catenin binding | molecular function | IPI[15304487] | |
GO:0045429 | positive regulation of nitric oxide biosynthetic process | biological process | IDA | |
GO:0008270 | zinc ion binding | molecular function | IEA | |
GO:0034056 | estrogen response element binding | molecular function | IDA[15345745] | |
GO:0060065 | uterus development | biological process | IEA | |
GO:0032355 | response to estradiol stimulus | biological process | IDA[15304487] | |
GO:0003707 | steroid hormone receptor activity | molecular function | TAS[10749889] | |
GO:0016021 | integral to membrane | cellular component | IEA | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular function | NAS[12552091] | |
GO:0060687 | regulation of branching involved in prostate gland morphogenesis | biological process | IEA | |
GO:0048146 | positive regulation of fibroblast proliferation | biological process | IEA | |
GO:0030284 | estrogen receptor activity | molecular function | NAS[3753802] | |
GO:0008584 | male gonad development | biological process | IEA | |
GO:0071391 | cellular response to estrogen stimulus | biological process | IEA | |
GO:0005515 | protein binding | molecular function | IPI[17363140] |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
MTA3_PATHWAY | mta3 pathway | Downregulated of MTA-3 in ER-negative Breast Tumors | Approximately 30% of breast carcinomas lack ER expression. P...... Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (cathepsin D, HSP27 (heat shock protein 27,000 kDa, aldolase A, dehydrogenase, alpha-tubulin, and glyceraldehyde-3-phosphat, Pdzk1, Greb ets) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrate that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. More... | |
CARM_ER_PATHWAY | carm er_pathway | CARM1 and Regulation of the Estrogen Receptor | Several forms of post-translational modification regulate pr...... Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. More... | |
HER2_PATHWAY | her2 pathway | Role of ERBB2 in Signal Transduction and Oncology | Her2 or ERBB2 belongs to a class of proteins having high hom...... Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors. The clinical importance of HER2 cannot be overstated. In addition, monoclonal antibody (Herceptin) against this receptor has been shown to be an effective treatment of breast cancer patients who have a high level of HER2 over expression. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_71 | gene expression | Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More... | |
REACT_15525 | nuclear receptor_transcription_pathway | A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More... |
ESR1 related interactors from protein-protein interaction data in HPRD (count: 189)
Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
ESR1 | SMARCA4 | No | in vivo;yeast 2-hybrid | 9099865 | |
ESR1 | STAT5A | No | in vitro;in vivo | 15304355 | |
ESR1 | SP1 | No | in vitro;in vivo | 15637147 , 10446910 | |
ESR1 | SMARCD3 | No | in vitro | 14701856 | |
ESR1 | ZNF398 | No | in vitro;yeast 2-hybrid | 11779858 | |
ESR1 | SOS1 | No | in vitro | 15173068 | |
ESR1 | PNRC2 | No | in vivo;yeast 2-hybrid | 11574675 , 15604093 | |
ESR1 | COBRA1 | No | in vitro;in vivo | 15342491 | |
ESR1 | BCAS2 | No | in vitro;in vivo;yeast 2-hybrid | 15694360 | |
ESR1 | HSP90AA1 | No | in vivo | 11911945 | |
ESR1 | STRN | No | in vitro;in vivo;yeast 2-hybrid | 15569929 | |
ESR1 | PIK3R1 | Yes | in vivo | 11689445 | |
ESR1 | BAG1 | No | in vivo | 8524784 | |
ESR1 | CALM3 | No | in vivo | 11981030 | |
ESR1 | RELA | No | in vitro | 7651415 | |
ESR1 | NR1H4 | No | in vivo | 17333335 | |
ESR1 | EGFR | No | in vitro | 11887937 | |
ESR1 | EIF3I | No | yeast 2-hybrid | 10706629 | |
ESR1 | CALM1 | No | in vivo | 11981030 | |
ESR1 | LOH3CR2A | No | in vitro;yeast 2-hybrid | 15474036 | |
ESR1 | RGS3 | No | in vitro;in vivo | 12198596 | |
ESR1 | PHB2 | No | in vitro | 10938099 , 15140878 | |
ESR1 | MAPK3 | No | in vitro;in vivo | 12118371 | |
ESR1 | HNF4A | No | in vitro;yeast 2-hybrid | 9717844 | |
ESR1 | SP3 | No | in vitro;in vivo | 10816575 | |
ESR1 | NPPA | No | yeast 2-hybrid | 15604093 | |
ESR1 | MMS19 | No | in vitro;yeast 2-hybrid | 11279242 | |
ESR1 | PTGES3 | No | in vivo | 10207098 | |
ESR1 | CHUK | No | in vivo | 15808510 | |
ESR1 | CCNH | No | in vivo | 12527756 | |
ESR1 | PIAS3 | No | in vitro;in vivo | 11117529 | |
ESR1 | ZBTB16 | Yes | in vitro | 14521715 | |
ESR1 | PRKACA | No | in vitro | 9891036 | |
ESR1 | ESRRA | No | in vitro | 9058380 | |
ESR1 | PGR | No | in vitro;in vivo;yeast 2-hybrid | 12612073 | |
ESR1 | SMARCA2 | No | in vivo | 9099865 | |
ESR1 | CUEDC2 | No | in vitro | 17347654 | |
ESR1 | BRCA1 | No | in vitro;in vivo | 10334989 , 11244506 , 12400015 | |
ESR1 | HSP90AB1 | No | in vitro | 11795466 | |
ESR1 | FOXO3 | No | in vitro;yeast 2-hybrid | 11435445 | |
ESR1 | IGF1R | No | in vivo | 10749889 , 16113100 | |
ESR1 | PELP1 | No | in vitro;in vivo | 11481323 | |
ESR1 | UBE2I | No | yeast 2-hybrid | 15666801 | |
ESR1 | RBM39 | No | in vitro | 11704680 | |
ESR1 | POU2F1 | No | in vivo | 10480874 | |
ESR1 | AR | Yes | in vitro | 12389206 | |
ESR1 | NSD1 | No | in vivo;yeast 2-hybrid | 9628876 | |
ESR1 | RPS6KA1 | No | in vitro;in vivo | 12093745 , 9528769 , 11507039 , 11139588 , 11432835 | |
ESR1 | JUNB | No | in vitro | 11477071 | |
ESR1 | EP300 | Yes | in vitro;in vivo | 11782371 | |
ESR1 | KIF1A | No | yeast 2-hybrid | 15604093 | |
ESR1 | DUT | No | yeast 2-hybrid | 15604093 | |
ESR1 | TAP1 | No | in vitro | 9774463 | |
ESR1 | TRIM24 | No | in vitro;in vivo | 9115274 , 9632676 , 10598587 | |
ESR1 | MED1 | No | in vitro;in vivo | 9653119 | |
ESR1 | POU4F2 | No | in vitro;yeast 2-hybrid | 9448000 | |
ESR1 | POLR2D | No | yeast 2-hybrid | 15604093 | |
ESR1 | POLR1B | No | in vitro | 11953755 | |
ESR1 | NCOR2 | No | in vivo | 9702189 | |
ESR1 | ARHGEF15 | No | yeast 2-hybrid | 15604093 | |
ESR1 | TP53 | No | in vitro | 10766163 | |
ESR1 | NCOA7 | No | in vivo | 11971969 | |
ESR1 | TDG | No | in vitro;in vivo;yeast 2-hybrid | 12874288 | |
ESR1 | CUL4B | No | in vivo | 17392787 | |
ESR1 | JUN | Yes | in vitro;in vivo | 11477071 | |
ESR1 | PIK3R3 | No | in vivo | 15001646 | |
ESR1 | MED24 | No | in vitro | 9653119 | |
ESR1 | CCNT1 | No | in vitro;in vivo | 15940264 | |
ESR1 | POU4F1 | No | in vitro;in vivo;yeast 2-hybrid | 9448000 | |
ESR1 | KDM5A | No | in vitro | 11358960 | |
ESR1 | GTF2H1 | No | in vitro;in vivo | 10949034 | |
ESR1 | TRIM59 | No | in vitro;in vivo;yeast 2-hybrid | 15941852 | |
ESR1 | REXO4 | No | in vitro;yeast 2-hybrid | 10908561 | |
ESR1 | CHD9 | No | in vitro | 16554032 | |
ESR1 | TSC2 | No | in vitro;in vivo | 15851513 | |
ESR1 | JUND | No | in vitro | 11477071 | |
ESR1 | THRB | No | in vitro | 9717844 | |
ESR1 | ESR2 | No | in vitro;in vivo | 9473491 | |
ESR1 | TRRAP | No | in vitro | 11931763 , 16260778 | |
ESR1 | HEXIM1 | No | in vivo | 15940264 | |
ESR1 | TRIP4 | No | in vitro;in vivo | 10454579 | |
ESR1 | NR2C1 | No | in vitro;in vivo | 12093804 | |
ESR1 | MPG | No | in vitro;in vivo | 14761960 | |
ESR1 | FOXO4 | No | in vitro | 11435445 | |
ESR1 | COPS5 | No | in vivo | 15899841 | |
ESR1 | PTPN1 | Yes | in vitro | 7539106 | |
ESR1 | MLL2 | No | in vitro | 16603732 | |
ESR1 | YWHAH | No | in vitro | 11266503 | |
ESR1 | NR2C2 | No | in vitro | 11844790 | |
ESR1 | SMARCE1 | No | in vitro | 12145209 | |
ESR1 | AKT2 | No | in vitro;in vivo | 11507039 , 11139588 , 11432835 , 9528769 | |
ESR1 | ITGB3BP | No | in vitro;in vivo | 15254226 | |
ESR1 | SLC30A9 | No | in vitro;in vivo | 15988012 | |
ESR1 | CDKN1A | No | in vitro | 17911387 | |
ESR1 | PAK1 | No | in vitro;in vivo | 12374744 | |
ESR1 | XBP1 | Yes | in vitro;in vivo | 12954762 | |
ESR1 | AHR | No | in vivo | 12612060 , 10620335 , 17392787 | |
ESR1 | CDK7 | No | in vivo | 15461668 | |
ESR1 | TAF10 | No | in vitro | 7923369 | |
ESR1 | GADD45B | No | in vitro | 10872826 | |
ESR1 | MKNK2 | No | yeast 2-hybrid | 11013076 | |
ESR1 | AKT1 | No | in vitro;in vivo | 11139588 | |
ESR1 | TUBA1B | No | in vivo | 15556606 | |
ESR1 | CTNNB1 | No | in vitro | 15304487 | |
ESR1 | CCND1 | Yes | in vitro;in vivo;yeast 2-hybrid | 9039267 , 11073968 | |
ESR1 | NRIP1 | No | in vitro | 7641693 | |
ESR1 | DDX5 | No | in vivo;yeast 2-hybrid | 12738788 | |
ESR1 | PRDM2 | No | in vivo;yeast 2-hybrid | 10706618 | |
ESR1 | CAV1 | No | in vitro | 11563984 | |
ESR1 | GTF2B | No | in vitro | 7641693 , 9841876 | |
ESR1 | MNAT1 | No | in vitro | 12527756 , 10949034 , 8308015 | |
ESR1 | RXRA | No | in vitro | 9717844 | |
ESR1 | SAFB | No | in vitro;in vivo | 10707955 | |
ESR1 | ZBTB17 | No | in vitro | 11117529 | |
ESR1 | RPS6KA3 | No | in vitro;in vivo | 11507039 , 11139588 , 11432835 , 9528769 | |
ESR1 | SREBF1 | No | in vitro;in vivo | 12021179 | |
ESR1 | MTA1 | No | in vivo | 12167865 | |
ESR1 | PRMT1 | No | in vitro | 11050077 | |
ESR1 | RFX4 | No | in vivo | 10706293 , 1603086 | |
ESR1 | BDNF | Yes | in vitro | 11923430 | |
ESR1 | CSNK2B | No | in vitro | 7838153 | |
ESR1 | ISL1 | No | in vitro;in vivo | 11043578 | |
ESR1 | SMAD4 | No | in vivo;yeast 2-hybrid | 11555647 , 12576474 | |
ESR1 | FOXO1 | No | in vitro;in vivo;yeast 2-hybrid | 11435445 , 11353774 | |
ESR1 | KAT5 | Yes | in vitro;in vivo | 16260778 | |
ESR1 | FHL2 | No | yeast 2-hybrid | 15666801 | |
ESR1 | NR0B2 | No | in vitro;in vivo | 11861507 , 9773978 | |
ESR1 | RARA | No | in vitro;yeast 2-hybrid | 9717844 , 17641689 | |
ESR1 | NCOA6 | No | yeast 2-hybrid | 10866662 | |
ESR1 | NCOA2 | No | in vitro | 11937504 | |
ESR1 | MDM2 | No | in vitro | 10766163 , 11178989 | |
ESR1 | HSPA4 | No | in vivo | 15556606 | |
ESR1 | SMAD2 | No | in vitro | 11555647 | |
ESR1 | NFKB1 | No | in vitro | 7651415 | |
ESR1 | LCK | No | in vitro;in vivo | 7539106 | |
ESR1 | AKAP13 | No | in vitro;in vivo | 9627117 | |
ESR1 | MVP | No | in vitro;in vivo | 9628887 | |
ESR1 | CEBPB | No | in vivo | 7651415 | |
ESR1 | MAPK1 | Yes | in vitro;in vivo | 12093745 , 9528769 | |
ESR1 | PTPN6 | Yes | in vitro | 7539106 | |
ESR1 | TBP | No | in vivo | 11595744 | |
ESR1 | GNAI1 | No | in vitro;in vivo | 11369763 | |
ESR1 | THRA | Yes | in vitro;yeast 2-hybrid | 9717844 | |
ESR1 | CDC25B | No | in vitro;in vivo | 11689696 | |
ESR1 | ERBB2 | No | in vitro;in vivo | 15173068 | |
ESR1 | TRIM28 | No | in vitro | 9774463 | |
ESR1 | RLIM | No | in vitro;in vivo | 19117995 | |
ESR1 | SMAD3 | No | in vitro;in vivo | 11555647 | |
ESR1 | LDB1 | No | in vitro;in vivo | 19117995 | |
ESR1 | NCOA3 | No | in vitro | 11050174 , 15145444 , 11353774 | |
ESR1 | MTCH2 | No | yeast 2-hybrid | 15604093 | |
ESR1 | PPARGC1A | No | in vitro;in vivo | 10748020 | |
ESR1 | PRMT2 | No | in vitro;in vivo | 12039952 | |
ESR1 | ARNT | No | in vitro | 15837795 | |
ESR1 | ESR1 | Yes | in vitro;in vivo | 10567404 , 11953755 , 10409727 | |
ESR1 | WIPI1 | No | in vitro | 15602573 | |
ESR1 | ATAD2 | No | in vitro;in vivo | 17998543 | |
ESR1 | PAK6 | No | in vitro;in vivo | 11773441 | |
ESR1 | DNTTIP2 | No | in vitro;in vivo;yeast 2-hybrid | 15047147 | |
ESR1 | NR0B1 | No | in vitro | 11053406 | |
ESR1 | BCAR1 | No | in vivo | 15020686 | |
ESR1 | NCOR1 | No | in vitro | 12145334 | |
ESR1 | TUBB | No | in vivo | 15556606 | |
ESR1 | PRPF6 | No | in vivo | 12039962 | |
ESR1 | SAFB2 | No | in vitro;in vivo | 12660241 | |
ESR1 | CALM2 | Yes | in vivo | 11981030 | |
ESR1 | TCF20 | No | in vitro;in vivo | 15831449 | |
ESR1 | GRB2 | No | in vitro;in vivo | 15173068 | |
ESR1 | MAPK14 | No | in vitro;in vivo | 12138194 | |
ESR1 | PSMC5 | No | in vitro;in vivo;yeast 2-hybrid | 8598193 , 14702340 | |
ESR1 | PIAS1 | No | yeast 2-hybrid | 15666801 | |
ESR1 | DDX54 | No | in vitro;yeast 2-hybrid | 12466272 | |
ESR1 | NR2F1 | No | in vitro;in vivo;yeast 2-hybrid | 12093745 | |
ESR1 | NR2F6 | No | in vitro | 10713182 | |
ESR1 | NCOA1 | No | in vitro | 9427757 , 11165056 | |
ESR1 | SRC | No | in vitro;yeast 2-hybrid | 7539106 , 12736255 , 15140878 | |
ESR1 | CITED1 | No | in vitro;in vivo | 11581164 | |
ESR1 | RNF4 | No | in vitro;in vivo | 11696545 | |
ESR1 | USF1 | No | in vitro | 15111769 | |
ESR1 | RBM23 | No | in vitro | 15694343 | |
ESR1 | RNF14 | No | in vitro;in vivo | 10085091 | |
ESR1 | GADD45G | No | in vitro | 10872826 | |
ESR1 | FLII | No | in vitro;in vivo | 14966289 | |
ESR1 | SHC1 | No | in vitro;in vivo | 11773443 | |
ESR1 | CREBBP | Yes | in vitro;in vivo | 8616895 | |
ESR1 | STUB1 | No | in vivo | 16037132 | |
ESR1 | TNFRSF14 | No | in vivo | 12093804 | |
ESR1 | PPARGC1B | No | in vitro;yeast 2-hybrid | 11854298 | |
ESR1 | RBM9 | No | in vivo | 11875103 |