Gene Report

Basic Information

Approved Symbol	ESR1
Approved Name	estrogen receptor 1
Previous Symbol	ESR
Symbol Alias	NR3A1, Era
Location	6q24-q27
Position	chr6:152420102-152420188 (+)
External Links	Entrez Gene: 2099 Ensembl: ENSG00000091831 UCSC: uc003qon.4 HGNC ID: 3467
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin

Positive relationships between ESR1 and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ER-alpha	Tsai, 2003	patients and normal controls	P-value<0.05	Statistical analysis showed a significant difference in the ...... Statistical analysis showed a significant difference in the II genotype and allele frequencies between the female MDD patients and the female controls ( P=0.010 and P=0.004, respectively). More...
ER	Geng, 2007	patients and normal controls		AR gene in MDD group have shorter microsatellites' length, a...... AR gene in MDD group have shorter microsatellites' length, and ER beta gene have shorter microsatellites' length and higher rates of S alleles, SS, genotype, and lower rate of LL genotype than control group. More...
ESR1	Ryan J, 2012	nomal people	P-value=0.009	Women homozygous for the variant G allele of ESR1 rs9340799 ...... Women homozygous for the variant G allele of ESR1 rs9340799 had a 1.6-fold increased risk of MDD across their lifetime compared with women who were homozygous for the A allele (p=0.009) More...

Positive relationships between ESR1 and other components at different levels (count: 0)

Positive relationship network of ESR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ESR1 and MDD (count: 0)

Negative relationships between ESR1 and other components at different levels (count: 0)

ESR1 related SNPs in MK4MDD (count: 0)

ESR1 related proteins in MK4MDD (count: 0)

ESR1 related GO terms (count: 87)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0002076	osteoblast development	biological process	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IDA[21937726]
GO:1990375	baculum development	biological process	IEA
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	NAS[12552091]
GO:0008013	beta-catenin binding	molecular function	IPI[15304487]
GO:0010467	gene expression	biological process	TAS
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	ISS
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[9328340\|10681512]
GO:0034056	estrogen response element binding	molecular function	IDA[15345745\|15831516\|17975005]
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS
GO:0043523	regulation of neuron apoptotic process	biological process	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0060523	prostate epithelial cord elongation	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[15569929\|17505058\|20074560\|20080953]
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[20074560]
GO:0016021	integral component of membrane	cellular component	IEA
GO:0032403	protein complex binding	molecular function	IEA
GO:0001223	transcription coactivator binding	molecular function	IEA
GO:0030235	nitric-oxide synthase regulator activity	molecular function	NAS[12389206]
GO:0060011	Sertoli cell proliferation	biological process	IEA
GO:0003682	chromatin binding	molecular function	IDA[17505058]
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	biological process	IEA
GO:0042562	hormone binding	molecular function	IEA
GO:0060687	regulation of branching involved in prostate gland morphogenesis	biological process	IEA
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[10816575]
GO:0060068	vagina development	biological process	IEA
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0042802	identical protein binding	molecular function	IPI[11265755\|11682626\|21182205\|23065768]
GO:0008209	androgen metabolic process	biological process	IEA
GO:0032355	response to estradiol	biological process	IDA[15304487]
GO:0043204	perikaryon	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA[17505058]
GO:0006338	chromatin remodeling	biological process	NAS[12351687]
GO:0030518	intracellular steroid hormone receptor signaling pathway	biological process	ISS
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IEA
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	biological process	IEA
GO:0001547	antral ovarian follicle growth	biological process	IEA
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	ISS
GO:0030315	T-tubule	cellular component	IEA
GO:0060745	mammary gland branching involved in pregnancy	biological process	IEA
GO:0051117	ATPase binding	molecular function	IDA[12058073]
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0010863	positive regulation of phospholipase C activity	biological process	ISS
GO:0060009	Sertoli cell development	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[11544182\|12047722\|15345745\|15831516]
GO:0030284	estrogen receptor activity	molecular function	NAS[3753802]
GO:0050679	positive regulation of epithelial cell proliferation	biological process	IEA
GO:0038052	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	molecular function	IDA[15831516]; IGI[18722177]
GO:0006351	transcription, DNA-templated	biological process	TAS[2040605]
GO:0051000	positive regulation of nitric-oxide synthase activity	biological process	IDA[21937726]
GO:0016020	membrane	cellular component	NAS[11960618]
GO:0005654	nucleoplasm	cellular component	TAS
GO:1901215	negative regulation of neuron death	biological process	IEA
GO:0035327	transcriptionally active chromatin	cellular component	IDA[17505058]
GO:0007165	signal transduction	biological process	TAS[10749889\|10970861]
GO:0019899	enzyme binding	molecular function	IPI[12039952\|22853951]
GO:0005739	mitochondrion	cellular component	IEA
GO:0043401	steroid hormone mediated signaling pathway	biological process	IEA
GO:0090209	negative regulation of triglyceride metabolic process	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IDA[15569929]
GO:0030520	intracellular estrogen receptor signaling pathway	biological process	NAS[3753802]
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[7641693\|7651415\|9328340\|9627117\|9628876\|9653119\|10359819\|10816575\|10866662\|11178989\|11265755\|11279242\|11353774\|11477071\|11581164\|11682626\|11875103\|12039952\|12093804\|12660241\|12917342\|14701856\|14764652\|14963108\|15199063\|15569929\|15674350\|15891768\|16603
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[15831516]
GO:0060065	uterus development	biological process	IEA
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[12047722]
GO:0000790	nuclear chromatin	cellular component	IDA[15831516]
GO:0005496	steroid binding	molecular function	ISS
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[3753802]
GO:0010629	negative regulation of gene expression	biological process	IDA[21695196]
GO:0043627	response to estrogen	biological process	IDA[11581164]
GO:0031798	type 1 metabotropic glutamate receptor binding	molecular function	IEA
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	molecular function	IEA
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IDA[7651415\|16043358]
GO:0005829	cytosol	cellular component	ISS
GO:0046697	decidualization	biological process	IEA
GO:0003707	steroid hormone receptor activity	molecular function	TAS[10749889]
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA
GO:0043234	protein complex	cellular component	IEA
GO:0046325	negative regulation of glucose import	biological process	IEA
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IDA[15345745]
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular function	IDA[12047722]
GO:0071392	cellular response to estradiol stimulus	biological process	IDA[15831516]; ISS
GO:0008134	transcription factor binding	molecular function	IPI[17505058]
GO:0060749	mammary gland alveolus development	biological process	IEA
GO:0048146	positive regulation of fibroblast proliferation	biological process	IEA

ESR1 related KEGG pathways (count: 0)

ESR1 related BioCarta pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
HER2_PATHWAY	her2 pathway	Role of ERBB2 in Signal Transduction and Oncology	Her2 or ERBB2 belongs to a class of proteins having high hom...... Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors. The clinical importance of HER2 cannot be overstated. In addition, monoclonal antibody (Herceptin) against this receptor has been shown to be an effective treatment of breast cancer patients who have a high level of HER2 over expression. More...
CARM_ER_PATHWAY	carm er_pathway	CARM1 and Regulation of the Estrogen Receptor	Several forms of post-translational modification regulate pr...... Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. More...
MTA3_PATHWAY	mta3 pathway	Downregulated of MTA-3 in ER-negative Breast Tumors	Approximately 30% of breast carcinomas lack ER expression. P...... Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (cathepsin D, HSP27 (heat shock protein 27,000 kDa, aldolase A, dehydrogenase, alpha-tubulin, and glyceraldehyde-3-phosphat, Pdzk1, Greb ets) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrate that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. More...

ESR1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_15525	nuclear receptor_transcription_pathway	A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More...

ESR1 related interactors from protein-protein interaction data in HPRD (count: 189)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ESR1	CALM1	Yes	in vivo	11981030
ESR1	SLC30A9	No	in vitro;in vivo	15988012
ESR1	CCNT1	No	in vitro;in vivo	15940264
ESR1	TUBB	No	in vivo	15556606
ESR1	HSPA4	No	in vivo	15556606
ESR1	MKNK2	No	yeast 2-hybrid	11013076
ESR1	ATAD2	No	in vitro;in vivo	17998543
ESR1	PPARGC1A	No	in vitro;in vivo	10748020
ESR1	THRA	Yes	in vitro;yeast 2-hybrid	9717844
ESR1	RNF14	No	in vitro;in vivo	10085091
ESR1	NR2C1	No	in vitro;in vivo	12093804
ESR1	BCAS2	No	in vitro;in vivo;yeast 2-hybrid	15694360
ESR1	NR1H4	No	in vivo	17333335
ESR1	STRN	No	in vitro;in vivo;yeast 2-hybrid	15569929
ESR1	MMS19	No	in vitro;yeast 2-hybrid	11279242
ESR1	JUNB	No	in vitro	11477071
ESR1	RBM23	No	in vitro	15694343
ESR1	PAK1	No	in vitro;in vivo	12374744
ESR1	ARNT	No	in vitro	15837795
ESR1	RPS6KA1	No	in vitro;in vivo	12093745 , 9528769 , 11507039 , 11139588 , 11432835
ESR1	GADD45B	No	in vitro	10872826
ESR1	ZNF398	No	in vitro;yeast 2-hybrid	11779858
ESR1	RGS3	No	in vitro;in vivo	12198596
ESR1	NRIP1	No	in vitro	7641693
ESR1	NCOR2	No	in vivo	9702189
ESR1	CALM3	No	in vivo	11981030
ESR1	DNTTIP2	No	in vitro;in vivo;yeast 2-hybrid	15047147
ESR1	ESR2	No	in vitro;in vivo	9473491
ESR1	JUN	Yes	in vitro;in vivo	11477071
ESR1	LOH3CR2A	No	in vitro;yeast 2-hybrid	15474036
ESR1	ISL1	No	in vitro;in vivo	11043578
ESR1	GTF2B	No	in vitro	7641693 , 9841876
ESR1	RBM39	No	in vitro	11704680
ESR1	RARA	No	in vitro;yeast 2-hybrid	9717844 , 17641689
ESR1	RFX4	No	in vivo	10706293 , 1603086
ESR1	SREBF1	No	in vitro;in vivo	12021179
ESR1	PTPN1	Yes	in vitro	7539106
ESR1	DUT	No	yeast 2-hybrid	15604093
ESR1	CAV1	No	in vitro	11563984
ESR1	MNAT1	No	in vitro	12527756 , 10949034 , 8308015
ESR1	ITGB3BP	No	in vitro;in vivo	15254226
ESR1	FOXO1	No	in vitro;in vivo;yeast 2-hybrid	11435445 , 11353774
ESR1	EGFR	No	in vitro	11887937
ESR1	HSP90AB1	No	in vitro	11795466
ESR1	YWHAH	No	in vitro	11266503
ESR1	NCOA7	No	in vivo	11971969
ESR1	TRIP4	No	in vitro;in vivo	10454579
ESR1	FHL2	No	yeast 2-hybrid	15666801
ESR1	CDK7	No	in vivo	15461668
ESR1	CUL4B	No	in vivo	17392787
ESR1	DDX5	No	in vivo;yeast 2-hybrid	12738788
ESR1	STUB1	No	in vivo	16037132
ESR1	RXRA	Yes	in vitro	9717844
ESR1	IGF1R	No	in vivo	10749889 , 16113100
ESR1	NCOR1	No	in vitro	12145334
ESR1	SOS1	No	in vitro	15173068
ESR1	NCOA6	No	yeast 2-hybrid	10866662
ESR1	AKT1	No	in vitro;in vivo	11139588
ESR1	ZBTB16	Yes	in vitro	14521715
ESR1	PIK3R1	Yes	in vivo	11689445
ESR1	CITED1	No	in vitro;in vivo	11581164
ESR1	PTPN6	Yes	in vitro	7539106
ESR1	EIF3I	No	yeast 2-hybrid	10706629
ESR1	CTNNB1	No	in vitro	15304487
ESR1	NSD1	No	in vivo;yeast 2-hybrid	9628876
ESR1	SAFB2	No	in vitro;in vivo	12660241
ESR1	SP1	No	in vitro;in vivo	15637147 , 10446910
ESR1	EP300	Yes	in vitro;in vivo	11782371
ESR1	MED1	No	in vitro;in vivo	9653119
ESR1	CHUK	No	in vivo	15808510
ESR1	BRCA1	No	in vitro;in vivo	10334989 , 11244506 , 12400015
ESR1	AHR	No	in vivo	12612060 , 10620335 , 17392787
ESR1	TNFRSF14	No	in vivo	12093804
ESR1	SMAD4	No	in vivo;yeast 2-hybrid	11555647 , 12576474
ESR1	GTF2H1	No	in vitro;in vivo	10949034
ESR1	PGR	No	in vitro;in vivo;yeast 2-hybrid	12612073
ESR1	RLIM	No	in vitro;in vivo	19117995
ESR1	POLR1B	No	in vitro	11953755
ESR1	MED24	No	in vitro	9653119
ESR1	TAF10	No	in vitro	7923369
ESR1	STAT5A	No	in vitro;in vivo	15304355
ESR1	NR0B1	No	in vitro	11053406
ESR1	NR2C2	No	in vitro	11844790
ESR1	FOXO3	No	in vitro;yeast 2-hybrid	11435445
ESR1	POU4F1	No	in vitro;in vivo;yeast 2-hybrid	9448000
ESR1	PRMT2	No	in vitro;in vivo	12039952
ESR1	TAP1	No	in vitro	9774463
ESR1	SP3	No	in vitro;in vivo	10816575
ESR1	PSMC5	No	in vitro;in vivo;yeast 2-hybrid	8598193 , 14702340
ESR1	TRIM59	No	in vitro;in vivo;yeast 2-hybrid	15941852
ESR1	ERBB2	No	in vitro;in vivo	15173068
ESR1	UBE2I	No	yeast 2-hybrid	15666801
ESR1	CALM2	Yes	in vivo	11981030
ESR1	ZBTB17	No	in vitro	11117529
ESR1	WIPI1	No	in vitro	15602573
ESR1	RBM9	No	in vivo	11875103
ESR1	TDG	No	in vitro;in vivo;yeast 2-hybrid	12874288
ESR1	HSP90AA1	No	in vivo	11911945
ESR1	SMAD3	No	in vitro;in vivo	11555647
ESR1	COBRA1	No	in vitro;in vivo	15342491
ESR1	XBP1	Yes	in vitro;in vivo	12954762
ESR1	PPARGC1B	No	in vitro;yeast 2-hybrid	11854298
ESR1	KDM5A	No	in vitro	11358960
ESR1	TRIM24	No	in vitro;in vivo	9115274 , 9632676 , 10598587
ESR1	TRRAP	No	in vitro	11931763 , 16260778
ESR1	CHD9	No	in vitro	16554032
ESR1	NCOA2	No	in vitro	11937504
ESR1	SRC	No	in vitro;yeast 2-hybrid	7539106 , 12736255 , 15140878
ESR1	NPPA	No	yeast 2-hybrid	15604093
ESR1	USF1	No	in vitro	15111769
ESR1	COPS5	No	in vivo	15899841
ESR1	SMARCA2	No	in vivo	9099865
ESR1	NCOA1	No	in vitro	9427757 , 11165056
ESR1	PNRC2	No	in vivo;yeast 2-hybrid	11574675 , 15604093
ESR1	MTA1	No	in vivo	12167865
ESR1	ESR1	Yes	in vitro;in vivo	10567404 , 11953755 , 10409727
ESR1	CDC25B	No	in vitro;in vivo	11689696
ESR1	POLR2D	No	yeast 2-hybrid	15604093
ESR1	NR2F1	No	in vitro;in vivo;yeast 2-hybrid	12093745
ESR1	NR0B2	No	in vitro;in vivo	11861507 , 9773978
ESR1	DDX54	No	in vitro;yeast 2-hybrid	12466272
ESR1	PRMT1	No	in vitro	11050077
ESR1	SMARCD3	No	in vitro	14701856
ESR1	MPG	No	in vitro;in vivo	14761960
ESR1	BAG1	No	in vivo	8524784
ESR1	FOXO4	No	in vitro	11435445
ESR1	CCND1	Yes	in vitro;in vivo;yeast 2-hybrid	9039267 , 11073968
ESR1	CUEDC2	No	in vitro	17347654
ESR1	PHB2	No	in vitro	10938099 , 15140878
ESR1	GRB2	No	in vitro;in vivo	15173068
ESR1	AR	Yes	in vitro	12389206
ESR1	NCOA3	No	in vitro	11050174 , 15145444 , 11353774
ESR1	TBP	No	in vivo	11595744
ESR1	LCK	No	in vitro;in vivo	7539106
ESR1	TCF20	No	in vitro;in vivo	15831449
ESR1	GNAI1	Yes	in vitro;in vivo	11369763
ESR1	RNF4	No	in vitro;in vivo	11696545
ESR1	ARHGEF15	No	yeast 2-hybrid	15604093
ESR1	LDB1	No	in vitro;in vivo	19117995
ESR1	POU4F2	No	in vitro;yeast 2-hybrid	9448000
ESR1	RELA	No	in vitro	7651415
ESR1	PRKACA	No	in vitro	9891036
ESR1	PTGES3	No	in vivo	10207098
ESR1	ESRRA	No	in vitro	9058380
ESR1	KAT5	Yes	in vitro;in vivo	16260778
ESR1	PIAS3	No	in vitro;in vivo	11117529
ESR1	CDKN1A	No	in vitro	17911387
ESR1	TRIM28	No	in vitro	9774463
ESR1	MVP	No	in vitro;in vivo	9628887
ESR1	MDM2	No	in vitro	10766163 , 11178989
ESR1	CCNH	No	in vivo	12527756
ESR1	GADD45G	No	in vitro	10872826
ESR1	SMARCE1	Yes	in vitro	12145209
ESR1	POU2F1	No	in vivo	10480874
ESR1	SMAD2	No	in vitro	11555647
ESR1	FLII	No	in vitro;in vivo	14966289
ESR1	PIK3R3	No	in vivo	15001646
ESR1	HEXIM1	Yes	in vivo	15940264
ESR1	RPS6KA3	No	in vitro;in vivo	11507039 , 11139588 , 11432835 , 9528769
ESR1	MAPK3	No	in vitro;in vivo	12118371
ESR1	TSC2	No	in vitro;in vivo	15851513
ESR1	CSNK2B	No	in vitro	7838153
ESR1	MTCH2	No	yeast 2-hybrid	15604093
ESR1	AKT2	No	in vitro;in vivo	11507039 , 11139588 , 11432835 , 9528769
ESR1	REXO4	No	in vitro;yeast 2-hybrid	10908561
ESR1	TP53	No	in vitro	10766163
ESR1	KIF1A	No	yeast 2-hybrid	15604093
ESR1	NR2F6	No	in vitro	10713182
ESR1	SHC1	No	in vitro;in vivo	11773443
ESR1	JUND	No	in vitro	11477071
ESR1	MAPK1	Yes	in vitro;in vivo	12093745 , 9528769
ESR1	CREBBP	Yes	in vitro;in vivo	8616895
ESR1	PAK6	No	in vitro;in vivo	11773441
ESR1	BDNF	Yes	in vitro	11923430
ESR1	MAPK14	Yes	in vitro;in vivo	12138194
ESR1	AKAP13	No	in vitro;in vivo	9627117
ESR1	PRDM2	No	in vivo;yeast 2-hybrid	10706618
ESR1	PIAS1	No	yeast 2-hybrid	15666801
ESR1	HNF4A	No	in vitro;yeast 2-hybrid	9717844
ESR1	THRB	No	in vitro	9717844
ESR1	PRPF6	No	in vivo	12039962
ESR1	SMARCA4	No	in vivo;yeast 2-hybrid	9099865
ESR1	NFKB1	No	in vitro	7651415
ESR1	MLL2	No	in vitro	16603732
ESR1	PELP1	No	in vitro;in vivo	11481323
ESR1	BCAR1	No	in vivo	15020686
ESR1	CEBPB	No	in vivo	7651415
ESR1	TUBA1B	No	in vivo	15556606
ESR1	SAFB	No	in vitro;in vivo	10707955

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways

Gene mapped Reactome pathways