MK4MDD

Gene Report

Basic Information
Approved Symbol BDNF
Approved Name brain-derived neurotrophic factor
Name Alias "neurotrophin"
Location 11p14.1
Position chr11:27742962-27743605 (-)
External Links Entrez Gene: 627
Ensembl: ENSG00000176697
UCSC: uc009yje.3
HGNC ID: 1033
No. of Studies (Positive/Negative) 28(19/9) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between BDNF and MDD (count: 9)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Brain Derived Neurotrophic Factor (BDNF) Lau, 2010 patients and normal controls P-value<0.05 Significant effects of diagnosis and diagnosis-by-genotype i...... Significant effects of diagnosis and diagnosis-by-genotype interactions (F's>4, p's<0.05) characterized activations in amygdala and anterior hippocampal regions. Greater activations in patients than healthy adolescents were found. Critically, these hyperactivations were modulated by BDNF genotype: Met-carriers showed greater neural responses of emotional faces than Val/Val homozygotes in patients only. More...
BDNF Schumacher, 2005 patients and normal controls P-value=0.00006 Haplotype analysis of marker combination rs988748-(GT)n-rs62...... Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016). Association with MDD was the most robust finding and could be replicated in a second German sample of MDD patients and control subjects (p = .0092, uncorrected). More...
BDNF Licinio, 2009 patients and normal controls Association analyses of patients with MDD and controls showe...... Association analyses of patients with MDD and controls showed that 6 SNPs in this gene were associated with MDD (rs12273539, rs11030103, rs6265, rs28722151, rs41282918, and rs11030101) More...
BDNF Zhang, 2010 patients and normal controls P-value<0.05 Further gene-gene interaction analyses showed a significant ...... Further gene-gene interaction analyses showed a significant effect of a two-locus BDNF/GSK3B interaction with MDD (GSK3B rs6782799 and BDNF rs7124442) (corrected P = 0.011), and also for a three-locus interaction (GSK3B rs6782799, BDNF rs6265 and BDNF rs7124442) (corrected P = 0.019). More...
BDNF Sun, 2011 patients and normal controls P-value<0.001 The analysis revealed a strong association between the BDNF ...... The analysis revealed a strong association between the BDNF G-712A genotype distribution and MD (p=0.0005). The frequency of the -712A allele was significantly higher in MD patients than in the healthy controls (p=0.0007). More...
BDNF Kanellopoulos, 2011 patients and normal controls elderly MDD BDNF val/val homozygotes had significantly highe...... elderly MDD BDNF val/val homozygotes had significantly higher right hippocampal volumes compared with nondepressed val/val subjects. In addition, depressed met carriers had an earlier age of onset of depressive illness than val/val homozygotes More...
BDNF Oral E, 2012 patients and normal controls The MDD group showed significantly poorer performance than t...... The MDD group showed significantly poorer performance than the control group in cognitive functions; they also had lower levels of BDNF than the control group. More...
BDNF D'Addario C, 2013 patients and normal controls P-value <0.05 A signi?cant reduction of BDNF gene expression in MDD subjec...... A signi?cant reduction of BDNF gene expression in MDD subjects (0.45, SD=10; p<.05, according to unpaired t test) versus controls(1.00, SD=21; Figure 1A)was observed. In addition, an increase of DNA methylation at BDNF gene promoter was observed in MDD patients, compared with control subjects (32.52% SD=2.03% vs.24.04% SD=2.08%; p <.05, according to unpaired t test; Figure 1B) More...
BDNF Frazier, 2014 Patients and nomal controls P = 0.034 Patients carrying one or two BDNF minor alleles (GA or AA ge...... Patients carrying one or two BDNF minor alleles (GA or AA genotypes) showed a nominally significant association with healthy controls, implying a protective effect of this allele for mood disorder. This effect remained significant when adjusting for race/ethnicity (P = 0.034). However, when corrected for multiple testing (four different genes tested), this association was no longer significant More...

Positive relationships between BDNF and other components at different levels (count: 16) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of BDNF in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between BDNF and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description
BDNF Tsai SJ, 2003 Patients and nomal controls No significant differences were demonstrated for the genotyp...... No significant differences were demonstrated for the genotype or allele frequency of the BDNF polymorphism comparing the MDD and control groups. More...
BDNF Hong CJ, 2003 Patients and nomal controls The genotype and allele frequencies for the BDNF gene Val66M...... The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. Furthermore, it was not demonstrated that this BDNF polymorphism was associated with age of onset or suicidal history in our mood disorder patients. More...
BDNF Liu X, 2009 Patients and nomal controls No significant associations with MDD were demonstrated for t...... No significant associations with MDD were demonstrated for three SNPs. More...
BDNF Zou YF, 2010 Patients and nomal controls In the multivariate regression analysis, there was no signif...... In the multivariate regression analysis, there was no significant association between severity of depression and BDNF Val66Met polymorphism. More...
BDNF Evinova A, 2012 patients and normal controls We found no significant association of either the BDNF G196A...... We found no significant association of either the BDNF G196A or MTHFR C677T polymorphisms with major depressive disorder neither in female nor male group of patients. More...
BDNF Lan, 2014 Patients and nomal controls p= 0.087 The MDD group met carriers had 0 subjects with AA and 16 sub...... The MDD group met carriers had 0 subjects with AA and 16 subjectswith AG and 34 subjects with GG allele. The HV group had 4 subjects with AA, 19 subjectswith AG and 27 with GG allele. The allelic distribution (number of G alleles) showed a trend of a difference between MDD and HV groups in the vall66met allele (p= 0.087), but no difference in the 5-HT1A receptor C-1019G allele (p = 0.125). More...
BDNF Gutierrez, 2015 patients only ¦Ö2=0.02, P=0.99 Genotype frequencies were found to be in Hardy¨CWeinberg equ...... Genotype frequencies were found to be in Hardy¨CWeinberg equilibrium in the whole sample (5-HTTLPR triallelic poly-morphism: ¦Ö2=2.46, P=0.29,5-HTTLPR biallelic polymorphism: ¦Ö2=0.27,P=0.87;BDNF Val66Met polymorphism: ¦Ö2=0.02, P=0.99)and separately in participants with MD at any point over the follow-up period and participants without this condition.Table 2 shows crude and adjusted main effects of SERT, BDNF and childhood maltreatment variables on MD. In brief, variation at the SERT 5-HTTLPR triallelic polymorphism was not found to be associated with MD. The analysis of the 5- HTTLPR biallelic polymorphism did not yield significant results either. However, the risk for MD was significantly increased among Val/Val BDNF homozygous participants (OR 1.250, 95% CI 1.034¨C1.512, p = 0.019). More...
BDNF Cruz-Fuentes, 2014 Patients and nomal controls ¦Ö2 = 0.3, P > 0.05 Table 1 also shows the observed genotype frequencies for the...... Table 1 also shows the observed genotype frequencies for the SLC6A4 promoter VNTR and the BDNF Val66Met polymorphisms in cases and controls; no deviation from HWE was detected in both cases: SLC6A4, ¦Ö2 = 0.4, P > 0.05; BDNF, ¦Ö2 = 0.3, P > 0.05. Moreover, no significant genotype or allele differences were observed between groups of comparison. However, when hierarchical diagnostic criteria for depression was used as the output variable, the SS SLC6A4 genotype (but not BDNF) was a predictor of major depression (Wald¡¯s statistic 5.8, P = 0.016, CI = 1.1¨C2.7). No significant gene 9 gene interaction was detected (Wald 0.54, P = 0.461). More...

Negative relationships between BDNF and other components at different levels (count: 6) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


BDNF related SNPs in MK4MDD (count: 1)
BDNF related proteins in MK4MDD (count: 1)
BDNF related GO terms (count: 39)
BDNF related KEGG pathways (count: 3)
BDNF related BioCarta pathways (count: 0)
BDNF related Reactome pathways (count: 0)
BDNF related interactors from protein-protein interaction data in HPRD (count: 10)