Gene Report

Basic Information

Approved Symbol	NTRK2
Approved Name	neurotrophic tyrosine kinase, receptor, type 2
Symbol Alias	TRKB
Location	9q22.1
Position	chr9:87283466-87638505 (+)
External Links	Entrez Gene: 4915 Ensembl: ENSG00000148053 UCSC: uc004anz.1 HGNC ID: 8032
No. of Studies (Positive/Negative)	5(5/0)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between NTRK2 and MDD (count: 4)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TrkB	Bernard, 2010	patients and normal controls		The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
NTRK2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
NTRK2	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus
NTRK2	Dong, 2009	patients and normal controls	P-value = 0.0002	The most significant association was found between NTRK2 hap...... The most significant association was found between NTRK2 haplotype CAG (rs2289658, rs2289657 and rs2289656) and relative reduction of HAM-D21 score with a nominal P = 0.0002 and an effect size of squared R = 0.20 More...

Positive relationships between NTRK2 and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
NTRK2		Hippocampus(hippocampus)	brain morphology and function	Sequeira, 2007	patients and normal controls	Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus
NTRK2		Suicide(suicide)	symptoms	Kohli, 2010	patients and normal controls	SNPs within NTRK2 were associated with suicide attempt among...... SNPs within NTRK2 were associated with suicide attempt among depressed patients More...

Positive relationship network of NTRK2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NTRK2 and MDD (count: 0)

Negative relationships between NTRK2 and other components at different levels (count: 0)

NTRK2 related SNPs in MK4MDD (count: 0)

NTRK2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
BDNF/NT-3 growth factors receptor	Q16620	1(1/0)	Literature-origin

NTRK2 related GO terms (count: 56)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0030182	neuron differentiation	biological process	ISS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:2000811	negative regulation of anoikis	biological process	IEA
GO:0060291	long-term synaptic potentiation	biological process	IEA
GO:0032314	regulation of Rac GTPase activity	biological process	ISS
GO:0001570	vasculogenesis	biological process	IEA
GO:0010628	positive regulation of gene expression	biological process	ISS
GO:0007568	aging	biological process	IEA
GO:0021954	central nervous system neuron development	biological process	ISS
GO:0043121	neurotrophin binding	molecular function	IDA[11738045]; ISS
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	biological process	IMP[15494731]
GO:0010976	positive regulation of neuron projection development	biological process	ISS
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS
GO:0021987	cerebral cortex development	biological process	ISS
GO:0010996	response to auditory stimulus	biological process	IEA
GO:0048709	oligodendrocyte differentiation	biological process	IEA
GO:0007631	feeding behavior	biological process	IEA
GO:0001764	neuron migration	biological process	ISS
GO:0048935	peripheral nervous system neuron development	biological process	IEA
GO:0060175	brain-derived neurotrophic factor-activated receptor activity	molecular function	IMP[15494731]
GO:0005829	cytosol	cellular component	IEA
GO:0030426	growth cone	cellular component	IEA
GO:0010008	endosome membrane	cellular component	IEA
GO:0043410	positive regulation of MAPK cascade	biological process	ISS
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	biological process	ISS
GO:0042490	mechanoreceptor differentiation	biological process	IEA
GO:0005887	integral to plasma membrane	cellular component	IDA[15494731]
GO:0007616	long-term memory	biological process	IEA
GO:0043524	negative regulation of neuron apoptotic process	biological process	ISS
GO:0035584	calcium-mediated signaling using intracellular calcium source	biological process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS
GO:0014069	postsynaptic density	cellular component	IEA
GO:0014047	glutamate secretion	biological process	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0005524	ATP binding	molecular function	IEA
GO:0048403	brain-derived neurotrophic factor binding	molecular function	ISS
GO:0050773	regulation of dendrite development	biological process	IEA
GO:0007612	learning	biological process	ISS
GO:0051896	regulation of protein kinase B signaling cascade	biological process	IEA
GO:0060076	excitatory synapse	cellular component	IEA
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA
GO:0050772	positive regulation of axonogenesis	biological process	ISS
GO:0046548	retinal rod cell development	biological process	IEA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0048786	presynaptic active zone	cellular component	IEA
GO:0046777	protein autophosphorylation	biological process	ISS
GO:0046928	regulation of neurotransmitter secretion	biological process	IEA
GO:0046875	ephrin receptor binding	molecular function	IEA
GO:0042803	protein homodimerization activity	molecular function	ISS
GO:0009986	cell surface	cellular component	IEA
GO:0008284	positive regulation of cell proliferation	biological process	ISS
GO:0007190	activation of adenylate cyclase activity	biological process	TAS

NTRK2 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04722	neurotrophin signaling_pathway	Neurotrophin signaling pathway	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04010	mapk signaling_pathway	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

NTRK2 related BioCarta pathways (count: 0)

NTRK2 related Reactome pathways (count: 1)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11061	signalling by_ngf	Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles i...... Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling. More...

NTRK2 related interactors from protein-protein interaction data in HPRD (count: 25)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NTRK2	FRS3	No	in vitro	11432792
NTRK2	DYNLL1	No	in vivo	11157096
NTRK2	UBB	No	in vivo	16701206
NTRK2	NCK2	No	in vitro;yeast 2-hybrid	12074588
NTRK2	NTRK2	Yes	in vitro;in vivo	10533983
NTRK2	SQSTM1	No	in vivo	12471037
NTRK2	DOK5	No	in vitro;yeast 2-hybrid	16647839
NTRK2	GIPC1	No	in vitro;in vivo;yeast 2-hybrid	11251075 , 15304335 , 14617818
NTRK2	NGFR	Yes	in vivo	9927421
NTRK2	NTF4	No	in vivo	11855816
NTRK2	SHC2	No	in vivo	12006576 , 9507002
NTRK2	RASGRF1	Yes	in vivo	15513915
NTRK2	SHC3	No	in vivo	9507002
NTRK2	NCK1	No	yeast 2-hybrid	12074588
NTRK2	PTPN11	No	in vitro	10386953
NTRK2	SH2B2	No	in vitro;in vivo	9856458
NTRK2	SH2B1	No	in vitro	9856458
NTRK2	PLCG1	No	in vitro;in vivo	12419535
NTRK2	NTF3	No	in vivo	8621424
NTRK2	FYN	No	in vitro;in vivo	9648856
NTRK2	TRAF6	No	in vitro	18457658
NTRK2	SHC1	No	in vitro;in vivo	12419535 , 16034442
NTRK2	PTPN1	Yes	in vitro	12237455
NTRK2	BDNF	Yes	in vitro;in vivo	9312147
NTRK2	KIDINS220	No	in vitro;in vivo	15167895

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways