MK4MDD

Gene Report

Basic Information
Approved Symbol NTRK2
Approved Name neurotrophic tyrosine kinase, receptor, type 2
Symbol Alias TRKB
Location 9q22.1
Position chr9:87636353-87638505 (+)
External Links Entrez Gene: 4915
Ensembl: ENSG00000148053
UCSC: uc004anz.1
HGNC ID: 8032
No. of Studies (Positive/Negative) 6(5/1) Help
Type Literature-origin; Protein mapped

Positive relationships between NTRK2 and MDD (count: 4)
Name in Literature Reference Research Type Statistical Result Relation Description Help
TrkB Bernard, 2010 patients and normal controls The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
NTRK2 Aston, 2005 patients and normal controls Genes altered in major depressive disorder Genes altered in major depressive disorder
NTRK2 Sequeira, 2007 patients and normal controls Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus
NTRK2 Dong, 2009 patients and normal controls P-value = 0.0002 The most significant association was found between NTRK2 hap...... The most significant association was found between NTRK2 haplotype CAG (rs2289658, rs2289657 and rs2289656) and relative reduction of HAM-D21 score with a nominal P = 0.0002 and an effect size of squared R = 0.20 More...

Positive relationships between NTRK2 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of NTRK2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NTRK2 and MDD (count: 0)
Negative relationships between NTRK2 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


NTRK2 related SNPs in MK4MDD (count: 0)
NTRK2 related proteins in MK4MDD (count: 1)
NTRK2 related GO terms (count: 71)
NTRK2 related KEGG pathways (count: 2)
NTRK2 related BioCarta pathways (count: 0)
NTRK2 related Reactome pathways (count: 1)
NTRK2 related interactors from protein-protein interaction data in HPRD (count: 25)