Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
Depression-like behaviors from animal model (depressive-like behavior)
|
cognition and behavior |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM |
Positive
|
BDNF (BDNF)
|
gene |
Cyclic AMP-responsive element-binding protein 1 (cAMP response element-binding protein (CREB)) |
protein |
|
BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF |
Positive
|
Cyclic AMP-responsive element-binding protein 1 (CREB)
|
protein |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF |
Positive
|
mapkkk cascade (ERK)
|
pathway |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF |
Positive
|
anhedonic-like behavior from animal model (anhedonic-like behavior)
|
cognition and behavior |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM |
Positive
|
BDNF (BDNF)
|
gene |
mapkkk cascade (signal-regulated kinase (ERK)) |
pathway |
|
BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF |
Positive
|
Anxiety-like behaviors from animal model (anxiety-like behavior)
|
cognition and behavior |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM |
Positive
|
Hippocampus (hippocampus)
|
brain morphology and function |
Brain-derived neurotrophic factor (BDNF) |
protein |
|
Adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration |
Positive
|