MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Schmidt HD, 2010 PubMed
Full Info	Schmidt HD, Duman RS. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 2010; 35(12): 2378-2391.

Study

Hypothesis or Background	Recent clinical studies demonstrate that serum levels of brain-derived neurotrophic factor (BDNF) are significantly decreased in patients with major depressive disorder (MDD) and that antidepressant treatments reverse this effect, indicating that serum BDNF is a biomarker of MDD. These findings raise the possibility that serum BDNF may also have effects on neuronal activity and behavior, but the functional significance of altered serum BDNF is unknown.
Sample Information	mice
Method Detail	To address this issue, we determined the influence of peripheral BDNF administration on depression- and anxiety-like behavior, including the forced swim test (FST), chronic unpredictable stress (CUS)/anhedonia, novelty-induced hypophagia (NIH) test, and elevated-plus maze (EPM). Furthermore, we examined adult hippocampal neurogenesis as well as hippocampal and striatal expression of BDNF, extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB), in order to determine whether peripherally administered BDNF produces antidepressant-like cellular responses in the brain
Method Keywords	dose administration; forced swimming test ; novelty-induced hypophagia test; elevated plus maze
Result	Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM. Moreover, adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration. We also found that BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF.
Conclusions	Taken together, these results indicate that peripheral/serum BDNF may not only represent a biomarker of MDD, but also have functional consequences on molecular signaling substrates, neurogenesis, and behavior.

Relationships reported by Schmidt HD, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
Depression-like behaviors from animal model (depressive-like behavior)	cognition and behavior	Brain-derived neurotrophic factor (BDNF)	protein		Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM	Positive
BDNF (BDNF)	gene	Cyclic AMP-responsive element-binding protein 1 (cAMP response element-binding protein (CREB))	protein		BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF	Positive
Cyclic AMP-responsive element-binding protein 1 (CREB)	protein	Brain-derived neurotrophic factor (BDNF)	protein		Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF	Positive
mapkkk cascade (ERK)	pathway	Brain-derived neurotrophic factor (BDNF)	protein		Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF	Positive
anhedonic-like behavior from animal model (anhedonic-like behavior)	cognition and behavior	Brain-derived neurotrophic factor (BDNF)	protein		Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM	Positive
BDNF (BDNF)	gene	mapkkk cascade (signal-regulated kinase (ERK))	pathway		BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF	Positive
Anxiety-like behaviors from animal model (anxiety-like behavior)	cognition and behavior	Brain-derived neurotrophic factor (BDNF)	protein		Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM	Positive
Hippocampus (hippocampus)	brain morphology and function	Brain-derived neurotrophic factor (BDNF)	protein		Adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration	Positive