Gene Report

Basic Information

Approved Symbol	CRHR1
Approved Name	corticotropin releasing hormone receptor 1
Previous Symbol	CRHR
Symbol Alias	CRF-R, CRF1
Name Alias	corticotropin-releasing factor receptor
Location	17q12-q22
Position	chr17:43697710-43913194 (+)
External Links	Entrez Gene: 1394 Ensembl: ENSG00000120088 UCSC: uc002ijm.3 HGNC ID: 2357
No. of Studies (Positive/Negative)	6(6/0)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between CRHR1 and MDD (count: 6)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CRHR1	Liu, 2006	patients and normal controls	P-value<0.001	We observed significant allele (P=0.0008) and genotype (P=0....... We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. More...
CRHR1	Papiol, 2007	patients and normal controls		rs110402, in CRHR1 gene, was associated with an increased ri...... rs110402, in CRHR1 gene, was associated with an increased risk to present a seasonal pattern and an early age of onset of the first depressive episode. More...
CRHR1	Bradley, 2008	patients and normal controls	P-value<0.01	We found significant gene x environment interactions with mu...... We found significant gene x environment interactions with multiple individual single-nucleotide polymorphisms (eg, rs110402, P = .008) as well as with a rs7209436-rs4792887-rs110402 haplotype spanning intron 1 (P < .001). More...
CRHR1	Polanczyk, 2009	high-risk people		A haplotype in CRHR1 has been suggested to exert a protectiv...... A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. More...
CRHR1	Xiao Z, 2011	patients and normal controls	allelic: P-value = 0.018, genotypic: P-value = 0.022	Allelic association between CRHR1 rs242939 and recurrent MDD...... Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775). More...
CRH receptor 1 (CRHR1) gene	Hsu, 2012	patients and normal controls		Among GG-homozygotes, BOLD signal in the subgenual cingulate...... Among GG-homozygotes, BOLD signal in the subgenual cingulate was greater in MDD participants (n = 9) compared with controls (n = 33). Among A-carriers, BOLD signal was smaller in MDD (n = 7) compared with controls (n = 50) in the hypothalamus, bilateral amygdala, and left nucleus accumbens. More...

Positive relationships between CRHR1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
CRHR1		BDNF(BDNF)	gene	Xiao Z, 2011	patients and normal controls	P-value = 0.05	BDNF and CRHR1 interactions were found in the significant 2-...... BDNF and CRHR1 interactions were found in the significant 2-locus, gene-gene interaction models (p = 0.05) using a generalized multifactor dimensionality reduction (GMDR) method. More...

Positive relationship network of CRHR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CRHR1 and MDD (count: 0)

Negative relationships between CRHR1 and other components at different levels (count: 0)

CRHR1 related SNPs in MK4MDD (count: 3)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs242924	chr17:43885367(Forward)	intron_variant; nc_transcript_variant; NMD_transcript_variant	1(1/0)
rs110402	chr17:43880047(Forward)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	2(2/0)
rs242939	chr17:43895579(Forward)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	3(3/0)

CRHR1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Corticotropin-releasing factor receptor 1	P34998	1(1/0)	Literature-origin

CRHR1 related GO terms (count: 40)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0051424	corticotropin-releasing hormone binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	TAS
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	IEA
GO:0007613	memory	biological process	IEA
GO:0043306	positive regulation of mast cell degranulation	biological process	IEA
GO:0032811	negative regulation of epinephrine secretion	biological process	IEA
GO:0006955	immune response	biological process	TAS[7692441]
GO:0033267	axon part	cellular component	IEA
GO:0007218	neuropeptide signaling pathway	biological process	IEA
GO:0035902	response to immobilization stress	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[18801728]
GO:0021854	hypothalamus development	biological process	IEA
GO:0032099	negative regulation of appetite	biological process	IEA
GO:0007567	parturition	biological process	TAS[10598591]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0032403	protein complex binding	molecular function	IEA
GO:0031982	vesicle	cellular component	IEA
GO:0043404	corticotropin-releasing hormone receptor activity	molecular function	IEA
GO:0008542	visual learning	biological process	IEA
GO:1901215	negative regulation of neuron death	biological process	IEA
GO:0001965	G-protein alpha-subunit binding	molecular function	IEA
GO:0045177	apical part of cell	cellular component	IEA
GO:0007565	female pregnancy	biological process	NAS[7585095]
GO:0030855	epithelial cell differentiation	biological process	IEA
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[10598591]
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[7692441]
GO:0005802	trans-Golgi network	cellular component	IEA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8243652]
GO:0001666	response to hypoxia	biological process	IEA
GO:0048148	behavioral response to cocaine	biological process	IEA
GO:0005887	integral to plasma membrane	cellular component	TAS[10598591]
GO:0005771	multivesicular body	cellular component	IEA
GO:0060291	long-term synaptic potentiation	biological process	IEA
GO:0048266	behavioral response to pain	biological process	IEA
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IEA
GO:0042755	eating behavior	biological process	IEA
GO:0035641	locomotory exploration behavior	biological process	IEA
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IEA
GO:0030425	dendrite	cellular component	IEA
GO:0015056	corticotrophin-releasing factor receptor activity	molecular function	IEA

CRHR1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04730	long term_depression	Long-term depression	Cerebellar long-term depression (LTD), thought to be a molec...... Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

CRHR1 related BioCarta pathways (count: 0)

CRHR1 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_18372	class b2_secretin_family_receptors	This family is known as Family B. This family is known as Family B.
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

CRHR1 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CRHR1	CALM1	No	in vitro	15670850
CRHR1	UCN	No	in vitro;in vivo	8612563 , 9423932
CRHR1	GNAI1	No	in vivo	10598591
CRHR1	CRH	No	in vivo	9178757
CRHR1	GNAS	Yes	in vivo	10598591
CRHR1	GNAQ	No	in vivo	10598591
CRHR1	GNAO1	No	in vivo	10598591
CRHR1	UCN3	Yes	in vitro	11416224

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways