MK4MDD

Gene Report

Basic Information
Approved Symbol CRHR1
Approved Name corticotropin releasing hormone receptor 1
Previous Symbol CRHR
Symbol Alias CRF-R, CRF1
Name Alias "corticotropin-releasing factor receptor"
Location 17q12-q22
Position chr17:43912131-43913194 (+)
External Links Entrez Gene: 1394
Ensembl: ENSG00000120088
UCSC: uc010dap.3
HGNC ID: 2357
No. of Studies (Positive/Negative) 7(6/1) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between CRHR1 and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
CRHR1 Liu, 2006 patients and normal controls P-value<0.001 We observed significant allele (P=0.0008) and genotype (P=0....... We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. More...
CRHR1 Papiol, 2007 patients and normal controls rs110402, in CRHR1 gene, was associated with an increased ri...... rs110402, in CRHR1 gene, was associated with an increased risk to present a seasonal pattern and an early age of onset of the first depressive episode. More...
CRHR1 Bradley, 2008 patients and normal controls P-value<0.01 We found significant gene x environment interactions with mu...... We found significant gene x environment interactions with multiple individual single-nucleotide polymorphisms (eg, rs110402, P = .008) as well as with a rs7209436-rs4792887-rs110402 haplotype spanning intron 1 (P < .001). More...
CRHR1 Polanczyk, 2009 high-risk people A haplotype in CRHR1 has been suggested to exert a protectiv...... A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. More...
CRHR1 Xiao Z, 2011 patients and normal controls allelic: P-value = 0.018, genotypic: P-value = 0.022 Allelic association between CRHR1 rs242939 and recurrent MDD...... Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775). More...
CRH receptor 1 (CRHR1) gene Hsu, 2012 patients and normal controls Among GG-homozygotes, BOLD signal in the subgenual cingulate...... Among GG-homozygotes, BOLD signal in the subgenual cingulate was greater in MDD participants (n = 9) compared with controls (n = 33). Among A-carriers, BOLD signal was smaller in MDD (n = 7) compared with controls (n = 50) in the hypothalamus, bilateral amygdala, and left nucleus accumbens. More...

Positive relationships between CRHR1 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of CRHR1 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CRHR1 and MDD (count: 0)
Negative relationships between CRHR1 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


CRHR1 related SNPs in MK4MDD (count: 2)
CRHR1 related proteins in MK4MDD (count: 1)
CRHR1 related GO terms (count: 18)
CRHR1 related KEGG pathways (count: 2)
CRHR1 related BioCarta pathways (count: 0)
CRHR1 related Reactome pathways (count: 4)
CRHR1 related interactors from protein-protein interaction data in HPRD (count: 8)