SNP Report

Name	rs242939 dbSNP Ensembl
Location	Chrchr17:43895579(Forward)
Variant Alleles	C/G/T/A
Ancestral Allele	T
Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant
Consequence to Transcript	downstream_gene_variant(ENST00000582044, ENST00000587305) intron_variant(ENST00000293493, ENST00000314537, ENST00000339069, ENST00000347197, ENST00000352855, ENST00000398285, ENST00000577353, ENST00000580955, ENST00000582766, ENST00000583888) nc_transcript_variant(ENST00000582766) NMD_transcript_variant(ENST00000347197, ENST00000580955, ENST00000583888)
No. of Studies (Positive/Negative)	3 (3/0)

Reference	Research Type	Statistical Result	Relation Description
Bosker, 2010	patients and normal controls		Significance of candidate SNPs for MDD identified from the l...... Significance of candidate SNPs for MDD identified from the literature within the GAIN MDD GWAS More...
Liu, 2006	patients and normal controls	P-value=0.0002	We observed significant allele (P=0.0008) and genotype (P=0....... We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. More...
Xiao Z, 2011	patients and normal controls	allelic: P-value = 0.018, genotypic: P-value= 0.022	Allelic association between CRHR1 rs242939 and recurrent MDD...... Allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio 0.454 (95% CI 0.266-0.775). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
CRHR1	corticotropin releasing hormone receptor 1	Literature-origin; SNP mapped; Protein mapped	6(6/0)