Gene Report

Basic Information

Approved Symbol	SORT1
Approved Name	sortilin 1
Symbol Alias	Gp95, NT3
Location	1p13.3
Position	chr1:109852187-109940563 (-)
External Links	Entrez Gene: 6272 Ensembl: ENSG00000134243 UCSC: uc001dxm.2 HGNC ID: 11186
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SORT1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SORT1	Belzeaux, 2010	patients and normal controls		We found that variations of mRNA levels for NRG1, SORT1 and ...... We found that variations of mRNA levels for NRG1, SORT1 and TPH1 were interesting state-dependent biological markers of the disease. More...

Positive relationships between SORT1 and other components at different levels (count: 0)

Positive relationship network of SORT1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SORT1 and MDD (count: 0)

Negative relationships between SORT1 and other components at different levels (count: 0)

SORT1 related SNPs in MK4MDD (count: 0)

SORT1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Sortilin	Q99523	0(0/0)	Gene mapped

SORT1 related GO terms (count: 40)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006897	endocytosis	biological process	IDA[11331584]
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0005769	early endosome	cellular component	IDA[11331584]
GO:0005905	coated pit	cellular component	IDA[11331584]
GO:0010468	regulation of gene expression	biological process	IMP[18258592]
GO:0030140	trans-Golgi network transport vesicle	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0032868	response to insulin stimulus	biological process	IMP[15992544]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0046323	glucose import	biological process	IMP[15992544]
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IDA[9756851]
GO:0010465	nerve growth factor receptor activity	molecular function	IDA[14985763]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IMP[18258592]
GO:0005768	endosome	cellular component	NAS
GO:0019899	enzyme binding	molecular function	IPI[10085125]
GO:0009986	cell surface	cellular component	IDA[10085125]
GO:0043066	negative regulation of apoptotic process	biological process	IDA[14985763]
GO:0005794	Golgi apparatus	cellular component	IDA[11331584]
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11331584]
GO:0097190	apoptotic signaling pathway	biological process	IMP[14985763]
GO:0005886	plasma membrane	cellular component	IDA[11331584]; NAS[14985763]
GO:0048227	plasma membrane to endosome transport	biological process	IDA[11331584]
GO:0032580	Golgi cisterna membrane	cellular component	IEA
GO:0030379	neurotensin receptor activity, non-G-protein coupled	molecular function	IDA[9756851]
GO:0008333	endosome to lysosome transport	biological process	IDA[11331584]
GO:0051005	negative regulation of lipoprotein lipase activity	biological process	IDA[10085125]
GO:0016050	vesicle organization	biological process	IDA[15992544]
GO:0032509	endosome transport via multivesicular body sorting pathway	biological process	IDA[11331584]
GO:0030136	clathrin-coated vesicle	cellular component	IDA[11331584]
GO:0031965	nuclear membrane	cellular component	IEA
GO:0005765	lysosomal membrane	cellular component	IEA
GO:0048406	nerve growth factor binding	molecular function	IPI[14985763]
GO:0006895	Golgi to endosome transport	biological process	IDA[11331584]
GO:0001503	ossification	biological process	IEA
GO:0010008	endosome membrane	cellular component	IEA
GO:0014902	myotube differentiation	biological process	IMP[18258592]
GO:0016021	integral to membrane	cellular component	IDA[15992544]
GO:0048011	nerve growth factor receptor signaling pathway	biological process	IMP[14985763]
GO:0030425	dendrite	cellular component	IEA
GO:0007218	neuropeptide signaling pathway	biological process	IDA[9756851]

SORT1 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04142	lysosome	Lysosome	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...
hsa04722	neurotrophin signaling_pathway	Neurotrophin signaling pathway	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...

SORT1 related BioCarta pathways (count: 0)

SORT1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19400	golgi associated_vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. More...
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...

SORT1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SORT1	NGF	No	in vitro;in vivo	14985763
SORT1	BDNF	Yes	in vitro;in vivo	15987945
SORT1	NGFR	Yes	in vivo	14985763
SORT1	GGA1	No	in vitro;in vivo;yeast 2-hybrid	11390366
SORT1	LRPAP1	No	in vitro	9013611
SORT1	GGA2	No	in vitro;in vivo;yeast 2-hybrid	11331584 , 11390366
SORT1	NTS	No	in vitro;in vivo	9756851 , 16087676

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways