MK4MDD

Gene Report

Basic Information
Approved Symbol NR3C1
Approved Name nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Previous Symbol GRL
Previous Name "nuclear receptor subfamily 3, group C, member 1"
Symbol Alias GR
Location 5q31-q32
Position chr5:143113303-143113322 (-)
External Links Entrez Gene: 2908
Ensembl: ENSG00000113580
UCSC: uc003lnb.3
HGNC ID: 7978
No. of Studies (Positive/Negative) 8(8/0) Help
Type Literature-origin; Protein mapped

Positive relationships between NR3C1 and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description Help
glucocorticoid receptor (GR) Klok, 2010 patients and normal controls P-value<0.05 Significantly lower expression levels (30-50%) were detected...... Significantly lower expression levels (30-50%) were detected for MR or GR in hippocampal, inferior frontal gyrus and cingulate gyrus tissue from MDD patients (p < .05) More...
NR3C1 van West, 2006 patients and normal controls P-value=0.02 In the Belgian sample, we observed significant allele (p=0.0...... In the Belgian sample, we observed significant allele (p=0.02) and genotype (p=0.02) association with an SNP in the promoter region (NR3C1-1); in the Swedish sample, we observed significant allele (p=0.02) and genotype (p=0.02) association with the R23K SNP. More...
Gralpha Matsubara, 2006 patients and normal controls Reduced expression of GRalpha mRNA was shown in both bipolar...... Reduced expression of GRalpha mRNA was shown in both bipolar and major depressive disorder patients in a current depressive state as well as in remission. More...
GR van Rossum EF, 2006 Patients and nomal controls Homozygous carriers of the BclI polymorphism and ER22/23EK-c...... Homozygous carriers of the BclI polymorphism and ER22/23EK-carriers had an increased risk of developing a major depressive episode. More...
NR3C1 Zobel, 2008 patients and normal controls We found association between the diagnosis of depression and...... We found association between the diagnosis of depression and DNA sequence variants in intron 2 as well as in the 5' region of the NR3C1 gene More...
glucocorticoid receptor Alt, 2010 patients and normal controls P-value<0.05 In MDD, total GR levels were unaltered, although GRalpha was...... In MDD, total GR levels were unaltered, although GRalpha was decreased in the amygdala and cingulate gyrus (p<0.05); transcripts containing exons 1B, 1C and 1F were lower, and 1D and1J were increased in some regions More...
NR3C1 Szczepankiewicz, 2011 patients and normal controls We have found three polymorphisms (rs6198, rs6191 and rs3338...... We have found three polymorphisms (rs6198, rs6191 and rs33388) to be associated with major depressive disorder (MDD) More...
GR¦Á Carvalho LA, 2014 patients and normal controls FC=0.8; P-value=0.019 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between NR3C1 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of NR3C1 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NR3C1 and MDD (count: 0)
Negative relationships between NR3C1 and other components at different levels (count: 0) Help
NR3C1 related SNPs in MK4MDD (count: 0)
NR3C1 related proteins in MK4MDD (count: 1)
NR3C1 related GO terms (count: 35)
NR3C1 related KEGG pathways (count: 1)
NR3C1 related BioCarta pathways (count: 2)
NR3C1 related Reactome pathways (count: 2)
NR3C1 related interactors from protein-protein interaction data in HPRD (count: 90)