MK4MDD

Gene Report

Basic Information
Approved Symbol EGR1
Approved Name early growth response 1
Symbol Alias TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225
Name Alias "nerve growth factor-induced protein A", "transcription factor ETR103", "zinc finger protein 225", "early growth response protein 1"
Location 5q23-q31
Position chr5:137803771-137805004 (+)
External Links Entrez Gene: 1958
Ensembl: ENSG00000120738
UCSC: uc003ldb.1
HGNC ID: 3238
No. of Studies (Positive/Negative) 3(3/0) Help
Type Literature-origin

Positive relationships between EGR1 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
NGFI-A Alt, 2010 patients and normal controls NGFI-A, a transcription factor of exon 1F was down-regulated...... NGFI-A, a transcription factor of exon 1F was down-regulated in the hippocampus of MDD patients More...
EGR1 Sibille E, 2009 animal model; patients and nomal controls R=0.88, P-value<5E-6; y slope=1.14 Downregulated in MDD patients Downregulated in MDD patients
EGR1 Kerman IA, 2012 patients and normal controls The greatest changes in expression were observed among trans...... The greatest changes in expression were observed among transcriptional regulators, including downregulation in the expression of TOB1, EGR1, and NR4A2 and their downstream targets. More...

Positive relationships between EGR1 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of EGR1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between EGR1 and MDD (count: 0)
Negative relationships between EGR1 and other components at different levels (count: 0) Help
EGR1 related SNPs in MK4MDD (count: 0)
EGR1 related proteins in MK4MDD (count: 0)
EGR1 related GO terms (count: 33)
EGR1 related KEGG pathways (count: 1)
EGR1 related BioCarta pathways (count: 1)
EGR1 related Reactome pathways (count: 0)
EGR1 related interactors from protein-protein interaction data in HPRD (count: 14)