Gene Report

Basic Information

Approved Symbol	DAP3
Approved Name	death associated protein 3
Symbol Alias	MRPS29, DAP-3, MRP-S29, bMRP-10, MGC126058, MGC126059, DKFZp686G12159
Name Alias	"mitochondrial 28S ribosomal protein S29"
Location	1q22
Position	chr1:155708034-155708320 (+)
External Links	Entrez Gene: 7818 Ensembl: ENSG00000132676 UCSC: uc001flr.3 HGNC ID: 2673
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DAP3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Death-associated protein 3	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between DAP3 and other components at different levels (count: 0)

Positive relationship network of DAP3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DAP3 and MDD (count: 0)

Negative relationships between DAP3 and other components at different levels (count: 0)

DAP3 related SNPs in MK4MDD (count: 0)

DAP3 related proteins in MK4MDD (count: 0)

DAP3 related GO terms (count: 14)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008637	apoptotic mitochondrial changes	biological process	IEA
GO:0070125	mitochondrial translational elongation	biological process	TAS
GO:0005763	mitochondrial small ribosomal subunit	cellular component	IBA
GO:0005654	nucleoplasm	cellular component	IDA
GO:0005739	mitochondrion	cellular component	IDA[20563667]
GO:0005515	protein binding	molecular function	IPI[19103604\|20563667]
GO:0006996	organelle organization	biological process	TAS
GO:0070124	mitochondrial translational initiation	biological process	TAS
GO:0097190	apoptotic signaling pathway	biological process	TAS[7499268]
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674\|22681889]
GO:0003735	structural constituent of ribosome	molecular function	IBA
GO:0070126	mitochondrial translational termination	biological process	TAS
GO:0032543	mitochondrial translation	biological process	TAS
GO:0005743	mitochondrial inner membrane	cellular component	TAS

DAP3 related KEGG pathways (count: 0)

DAP3 related BioCarta pathways (count: 0)

DAP3 related Reactome pathways (count: 0)

DAP3 related interactors from protein-protein interaction data in HPRD (count: 9)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DAP3	DAP3	Yes	in vitro	10903152
DAP3	PPARA	No	in vitro	10903152
DAP3	HIF1A	No	in vitro	10903152
DAP3	AHR	No	in vitro	10903152
DAP3	FADD	No	in vivo;yeast 2-hybrid	11753396 , 11376335
DAP3	HSP90AA1	No	in vitro;in vivo	10903152
DAP3	NR3C1	Yes	in vitro;in vivo;yeast 2-hybrid	12099703 , 10903152
DAP3	TNFRSF10A	No	in vivo;yeast 2-hybrid	11376335
DAP3	AR	Yes	in vitro;yeast 2-hybrid	10903152

Gene Report

Gene mapped GO terms