Gene Report

Basic Information

Approved Symbol	NR3C2
Approved Name	nuclear receptor subfamily 3, group C, member 2
Previous Symbol	MLR
Symbol Alias	MR
Location	4q31
Position	chr4:148999915-149363672 (-)
External Links	Entrez Gene: 4306 Ensembl: ENSG00000151623 UCSC: uc003ilj.4 HGNC ID: 7979
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin; SNP mapped

Positive relationships between NR3C2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
mineralocorticoid receptor (MR)	Klok, 2010	patients and normal controls	P-value<0.05	Significantly lower expression levels (30-50%) were detected...... Significantly lower expression levels (30-50%) were detected for MR or GR in hippocampal, inferior frontal gyrus and cingulate gyrus tissue from MDD patients (p < .05) More...

Positive relationships between NR3C2 and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
mineralocorticoid receptor		Reward processing(reward learning)	cognition and behavior	Bogdan R, 2010	normal people		Reward learning was enhanced in val carriers(at rs5522 of mi...... Reward learning was enhanced in val carriers(at rs5522 of mineralocorticoid receptor gene) More...
MR		Cortisol awakening response(cortisol awakening response (CAR))	signs	Klok, 2011	patients and normal controls	P-value=0.03	MR -2C/C genotype was associated with an attenuated CAR incr...... MR -2C/C genotype was associated with an attenuated CAR increase in women (p=.03) but not in men (p=.18; p=.01 for SNP-by-sex interaction). The MR I180V SNP had no significant effect on the CAR. More...

Positive relationship network of NR3C2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NR3C2 and MDD (count: 0)

Negative relationships between NR3C2 and other components at different levels (count: 0)

NR3C2 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs5522	chr4:149357475(Forward)	missense_variant	1(1/0)

NR3C2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Mineralocorticoid receptor	P08235	0(0/0)	Gene mapped

NR3C2 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[11518808]
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0005496	steroid binding	molecular function	IEA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0007165	signal transduction	biological process	TAS[3037703]
GO:0006883	cellular sodium ion homeostasis	biological process	IEA
GO:0043565	sequence-specific DNA binding	molecular function	IEA
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA
GO:0007588	excretion	biological process	IEA
GO:0003707	steroid hormone receptor activity	molecular function	IEA
GO:0010467	gene expression	biological process	TAS

NR3C2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04960	aldosterone regulated_sodium_reabsorption	Aldosterone-regulated sodium reabsorption	Sodium transport across the tight epithelia of Na+ reabsorbi...... Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteosomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented. More...

NR3C2 related BioCarta pathways (count: 0)

NR3C2 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15525	nuclear receptor_transcription_pathway	A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More...
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...

NR3C2 related interactors from protein-protein interaction data in HPRD (count: 12)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NR3C2	PTGES3	No	in vitro;in vivo	10691735
NR3C2	TRIM24	No	in vitro	9115274 , 11518808
NR3C2	HSP90AA1	No	in vitro	9392437
NR3C2	HSPA4	No	in vitro	9392437
NR3C2	ACTG1	No	in vitro	8612804
NR3C2	PROX1	No	yeast 2-hybrid	15604093
NR3C2	ACTA1	No	in vitro	8612804
NR3C2	PIAS3	No	in vitro;in vivo;yeast 2-hybrid	15171715
NR3C2	NR3C1	Yes	in vitro;in vivo	11154266
NR3C2	PIAS1	No	in vitro;in vivo;yeast 2-hybrid	14500761
NR3C2	AR	Yes	yeast 2-hybrid	12644298
NR3C2	FKBP4	Yes	in vitro	9392437

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways