MK4MDD

Gene Report

Basic Information
Approved Symbol NR3C2
Approved Name nuclear receptor subfamily 3, group C, member 2
Previous Symbol MLR
Symbol Alias MR
Location 4q31
Position chr4:149365678-149365850 (-)
External Links Entrez Gene: 4306
Ensembl: ENSG00000151623
UCSC: uc003ilj.4
HGNC ID: 7979
No. of Studies (Positive/Negative) 3(3/0) Help
Type Literature-origin; SNP mapped

Positive relationships between NR3C2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
mineralocorticoid receptor (MR) Klok, 2010 patients and normal controls P-value<0.05 Significantly lower expression levels (30-50%) were detected...... Significantly lower expression levels (30-50%) were detected for MR or GR in hippocampal, inferior frontal gyrus and cingulate gyrus tissue from MDD patients (p < .05) More...

Positive relationships between NR3C2 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of NR3C2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NR3C2 and MDD (count: 0)
Negative relationships between NR3C2 and other components at different levels (count: 0) Help
NR3C2 related SNPs in MK4MDD (count: 1)
NR3C2 related proteins in MK4MDD (count: 0)
NR3C2 related GO terms (count: 14)
NR3C2 related KEGG pathways (count: 1)
NR3C2 related BioCarta pathways (count: 0)
NR3C2 related Reactome pathways (count: 2)
NR3C2 related interactors from protein-protein interaction data in HPRD (count: 12)