MK4MDD

Gene Report

Basic Information
Approved Symbol IL1B
Approved Name interleukin 1, beta
Symbol Alias IL1F2, IL-1B, IL1-BETA
Location 2q14
Position chr2:113594285-113594356 (-)
External Links Entrez Gene: 3553
Ensembl: ENSG00000125538
UCSC: uc002tii.1
HGNC ID: 5992
No. of Studies (Positive/Negative) 4(3/1) Help
Type Literature-origin; Protein mapped

Positive relationships between IL1B and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL-1beta Yu, 2003 patients and normal controls No significant difference was found in the genetic polymorph...... No significant difference was found in the genetic polymorphism between MDD patients and controls. However, MDD patients who were homozygous for the -511T allele of the IL-1beta gene had a trend of less severity of depressive symptoms and more favorable fluoxetine therapeutic response than -511C carriers. More...
IL1B Hwang, 2009 patients and normal controls P-value = 0.021 Compared with depressed subjects carrying the -511C allele, ...... Compared with depressed subjects carrying the -511C allele, depressed subjects who were -511T homozygotes showed a significantly later depression age of onset of 7 years (P = 0.021). More...
IL1¦Â Carvalho LA, 2014 patients and normal controls FC=3.8; P-value=0.002 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between IL1B and other components at different levels (count: 0) Help
Positive relationship network of IL1B in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between IL1B and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
interleukin-1beta Borkowska, 2011 patients and normal controls P-value=0.064 A specific haplotype in this gene, composed of the C allele ...... A specific haplotype in this gene, composed of the C allele at -31 and the T allele at -511, has a tendency to have a statistically significant difference (p = 0.064) between patients and control group. More...

Negative relationships between IL1B and other components at different levels (count: 0) Help
IL1B related SNPs in MK4MDD (count: 0)
IL1B related proteins in MK4MDD (count: 1)
IL1B related GO terms (count: 125)
IL1B related KEGG pathways (count: 12)
IL1B related BioCarta pathways (count: 3)
IL1B related Reactome pathways (count: 0)
IL1B related interactors from protein-protein interaction data in HPRD (count: 10)