Gene Report

Basic Information

Approved Symbol	APLP1
Approved Name	amyloid beta (A4) precursor-like protein 1
Symbol Alias	APLP
Name Alias	amyloid-like protein 1, "amyloid precursor-like protein 1"
Location	19q
Position	chr19:36359401-36370699 (+)
External Links	Entrez Gene: 333 Ensembl: ENSG00000105290 UCSC: uc002ocf.3 HGNC ID: 597
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between APLP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
APLP1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between APLP1 and other components at different levels (count: 0)

Positive relationship network of APLP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between APLP1 and MDD (count: 0)

Negative relationships between APLP1 and other components at different levels (count: 0)

APLP1 related SNPs in MK4MDD (count: 0)

APLP1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Amyloid-like protein 1	P51693	0(0/0)	Gene mapped

APLP1 related GO terms (count: 24)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006897	endocytosis	biological process	IEA
GO:0046914	transition metal ion binding	molecular function	IEA
GO:0030198	extracellular matrix organization	biological process	IEA
GO:0042802	identical protein binding	molecular function	IPI[16193067]
GO:0005515	protein binding	molecular function	IPI[16193067]
GO:0007155	cell adhesion	biological process	IEA
GO:0031694	alpha-2A adrenergic receptor binding	molecular function	IPI[16531006]
GO:0006378	mRNA polyadenylation	biological process	IEA
GO:0030900	forebrain development	biological process	IEA
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[16531006]
GO:0009887	organ morphogenesis	biological process	TAS[9521588]
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[16531006]
GO:0031696	alpha-2C adrenergic receptor binding	molecular function	IPI[16531006]
GO:0016021	integral to membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	IDA[16531006]
GO:0006417	regulation of translation	biological process	IEA
GO:0031695	alpha-2B adrenergic receptor binding	molecular function	IPI[16531006]
GO:0007399	nervous system development	biological process	TAS[9521588]
GO:0071874	cellular response to norepinephrine stimulus	biological process	IDA[16531006]
GO:0008201	heparin binding	molecular function	IEA
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0005604	basement membrane	cellular component	TAS[9521588]
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IC[16531006]

APLP1 related KEGG pathways (count: 0)

APLP1 related BioCarta pathways (count: 0)

APLP1 related Reactome pathways (count: 0)

APLP1 related interactors from protein-protein interaction data in HPRD (count: 23)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
APLP1	TSC22D1	No	yeast 2-hybrid	16169070
APLP1	GSTM4	Yes	yeast 2-hybrid	16169070
APLP1	DAB1	No	in vitro;in vivo;yeast 2-hybrid	10460257
APLP1	PRNP	No	in vivo	15146195
APLP1	CDKN2C	No	yeast 2-hybrid	16169070
APLP1	HSPE1	No	yeast 2-hybrid	16169070
APLP1	HLA-DQA1	No	yeast 2-hybrid	16169070
APLP1	MPHOSPH6	No	yeast 2-hybrid	16169070
APLP1	PNP	No	yeast 2-hybrid	16169070
APLP1	EIF2S2	No	yeast 2-hybrid	16169070
APLP1	APBB1	No	in vitro;yeast 2-hybrid	8894693
APLP1	TK1	No	yeast 2-hybrid	16169070
APLP1	NACA	No	yeast 2-hybrid	16169070
APLP1	SAT1	Yes	yeast 2-hybrid	16169070
APLP1	TCF21	No	yeast 2-hybrid	16169070
APLP1	STX5	No	yeast 2-hybrid	16169070
APLP1	TMSB4X	No	yeast 2-hybrid	16169070
APLP1	ZNF24	No	yeast 2-hybrid	16169070
APLP1	PCDHA4	No	yeast 2-hybrid	16169070
APLP1	CRCT1	No	yeast 2-hybrid	16169070
APLP1	TOE1	No	yeast 2-hybrid	16169070
APLP1	PHF10	No	yeast 2-hybrid	16169070
APLP1	UTP14A	No	yeast 2-hybrid	16169070

Gene Report

Literature-origin GO terms

Gene mapped GO terms