KEGG Pathway Report
Basic Information
| ID |
hsa04664
|
| Name |
fc epsilon_ri_signaling_pathway
|
| Brief Description |
Fc epsilon RI signaling pathway
|
| Full Description |
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses. |
hsa04664 related genes in MK4MDD (count: 16)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| IL13 |
interleukin 13 |
Literature-origin; Protein mapped
|
1(1/0) |
| RAC2 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
Literature-origin
|
1(1/0) |
| IL4 |
interleukin 4 |
Protein mapped
|
0(0/0) |
| BTK |
Bruton agammaglobulinemia tyrosine kinase |
Literature-origin
|
1(1/0) |
| PRKCB |
protein kinase C, beta |
Protein mapped
|
0(0/0) |
| TNF |
tumor necrosis factor |
Literature-origin; SNP mapped; Protein mapped
|
5(5/0) |
| IL5 |
interleukin 5 (colony-stimulating factor, eosinophil) |
Literature-origin; Protein mapped
|
1(1/0) |
| NRAS |
neuroblastoma RAS viral (v-ras) oncogene homolog |
Protein mapped
|
0(0/0) |
| PIK3R1 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Literature-origin
|
1(1/0) |
| PRKCE |
protein kinase C, epsilon |
Protein mapped
|
0(0/0) |
| MAPK12 |
mitogen-activated protein kinase 12 |
Literature-origin
|
1(1/0) |
| MAPK1 |
mitogen-activated protein kinase 1 |
Literature-origin
|
2(2/0) |
| MAPK8 |
mitogen-activated protein kinase 8 |
Literature-origin
|
1(1/0) |
| IL3 |
interleukin 3 (colony-stimulating factor, multiple) |
Literature-origin
|
1(1/0) |
| KRAS |
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
| HRAS |
v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
