MK4MDD

Brain Morphology and Function Report

Basic Information
Name Midbrain
Brain Morphology "Midbrain- the rostral part of the brain stem, which includes the tectum and tegmentum."
Brain Function "It is involved in functions such as vision, hearing, eyemovement, and body movement. The anterior part has the cerebral peduncle, which is a huge bundle of axons traveling from the cerebral cortex through the brain stem and these fibers (along with other structures) are important for voluntary motor function. "
Picture Midbrain From Wiki. Magnify
No. of Studies (Positive/Negative) 12(10/2) Help

Positive relationships between Midbrain and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description Help
midbrain Kumar, 2008 patients and normal controls Patients with MDD had significantly reduced reward-learning ...... Patients with MDD had significantly reduced reward-learning signals in midbrain. More...
midbrain Nofzinger, 2004 patients and normal controls depressed patients showed greater activation in the midbrain...... depressed patients showed greater activation in the midbrain reticular formation. More...
midbrain Newberg, 2005 patients and normal controls P-value = 0.01 in MDD patients (1.81, SD = 0.07) than in controls (1.95, SD = 0.13). (123)I-ADAM binding to SERT(serotonin transporter) in the mi...... (123)I-ADAM binding to SERT(serotonin transporter) in the midbrain was significantly lower (P = 0.01) in MDD patients (1.81 +/- 0.07) than in controls (1.95 +/- 0.13). More...
midbrain Parsey, 2006 patients and normal controls Post hoc analysis revealed lower binding potential(serotonin...... Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the midbrain. More...
midbrain Joensuu, 2007 patients and normal controls lower (-10%) binding potential The patients had a significantly lower (-10%) binding potent...... The patients had a significantly lower (-10%) binding potential in the midbrain region than controls. More...
midbrain Miller, 2008 patients and normal controls Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
midbrain Lehto, 2008 patients and normal controls Major depression groups had lower midbrain [123I] nor-beta-C...... Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. More...
midbrain Lee, 2011 patients and normal controls Decreased gray matter concentration (GMC) was found in MDD p...... Decreased gray matter concentration (GMC) was found in MDD patients in the midbrain encompassing the dorsal raphe nuclei (DRN). More...

Positive relationships between Midbrain and other components at different levels (count: 6) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Midbrain in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Midbrain and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
midbrain Ichimiya, 2002 patients and normal controls Binding potential in the midbrain did not differ between the...... Binding potential in the midbrain did not differ between the groups. More...

Negative relationships between Midbrain and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment