MK4MDD

Brain Morphology and Function Report

Basic Information
Name Insula
Brain Morphology "Insula- is a portion of the cerebral cortex folded deep within the lateral sulcus between the temporal lobe and the frontal lobe. The cortical area overlying it towards the lateral surface of the brain is the operculum (meaning ""lid""). The opercula are formed from parts of the enclosing frontal, temporal and parietal lobes. It is believed to be involved in consciousness. "
Brain Function "The insulae play a role in diverse functions usually linked to emotion or the regulation of the body's homeostasis. These functions include perception, motor control, self-awareness, cognitive functioning, and interpersonal experience. In relation to these it is involved in psychopathology."
Picture Insula Source Magnify
No. of Studies (Positive/Negative) 20(20/0) Help

Positive relationships between Insula and MDD (count: 15)
Name in Literature Reference Research Type Statistical Result Relation Description Help
insula Mitterschiffthaler, 2003 patients and normal controls Patients, compared to controls, showed increased activation ...... Patients, compared to controls, showed increased activation in insula. More...
insula Kimbrell, 2002 patients and normal controls Compared with control subjects, the subgroup of patients wit...... Compared with control subjects, the subgroup of patients with Hamilton depression scores of 22 or greater demonstrated decreased absolute rCMRglu bilaterally in the insula More...
contralateral insula Bar, 2007 patients and normal controls Patients displayed a stronger parametric BOLD signal increas...... Patients displayed a stronger parametric BOLD signal increase in the contralateral insula. More...
insula Cannon, 2007 patients and normal controls increased 5-HTT BP in the insula (15%) Relative to the healthy group both MDD and BD groups showed ...... Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the insula (15%). More...
insula Johnstone, 2007 patients and normal controls Pupil dilation data suggest that those depressed patients wh...... Pupil dilation data suggest that those depressed patients who expend more effort to reappraise negative stimuli are characterized by accentuated activation in the insula, whereas nondepressed individuals exhibit the opposite pattern. More...
insula Wang, 2008 patients and normal controls Patients also revealed a reversed activation pattern from co...... Patients also revealed a reversed activation pattern from controls in response to this contrast in the insula More...
bilateral insula Hosokawa, 2009 patients and normal controls Compared with healthy controls, the depressed UP (unipolar m...... Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral insula. More...
insula Halari, 2009 patients and normal controls Adolescents with depression compared to healthy controls dem...... Adolescents with depression compared to healthy controls demonstrated reduced activation in putamen, insula and temporal lobes during the Switch task. More...
insula Zhang, 2009 patients and normal controls Compared with healthy participants, patients with major depr...... Compared with healthy participants, patients with major depressive disorder showed significantly decreased local gyrification index in the insula, More...
insular Herwig, 2010 patients and normal controls Differences between healthy and depressed persons were found...... Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations. More...
insula Hwang, 2010 patients and normal controls Late-onset depression was associated with smaller volumes in...... Late-onset depression was associated with smaller volumes in several regions of gray matter (insula and the posterior cingulate region) and white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum). More...
insula Townsend, 2010 patients and normal controls In a between-group comparison, patients showed significantly...... In a between-group comparison, patients showed significantly reduced activation in the insula, temporal and occipital cortices. More...
insula Deschwanden, 2011 patients and normal controls The PET study revealed lower levels of regional mGluR5 bindi...... The PET study revealed lower levels of regional mGluR5 binding in the prefrontal cortex, the cingulate cortex, the insula, the thalamus, and the hippocampus in the depression group relative to the comparison group. More...
insula Jin, 2011 patients and normal controls Our results showed that the topological properties of depres...... Our results showed that the topological properties of depressed adolescents' networks were significantly disrupted compared with HC. Dysregulation of brain regions were found in the insula. More...
insula Levesque, 2011 high-risk people In children whose mothers exhibited higher depressive sympto...... In children whose mothers exhibited higher depressive symptomatology, compared to children whose mothers displayed lower depressive symptomatology, altered neural responses to sad film excerpts were noted in brain regions known to be involved in sadness and MD, notably the insula, anterior cingulate cortex and caudate nucleus, even though the children did not differ in current mood. More...

Positive relationships between Insula and other components at different levels (count: 9) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Insula in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Insula and MDD (count: 0)
Negative relationships between Insula and other components at different levels (count: 0) Help