Protein Report

Protein Name	Pro-opiomelanocortin
UniPortKB	P01189
No. of Studies (Positive/Negative)	20 (20/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
adrenocorticotropic hormone (ACTH)	Heim, 2000	patients and normal controls	P-value<0.001	Women with a history of childhood abuse and a current major ...... Women with a history of childhood abuse and a current major depression diagnosis exhibited a more than 6-fold greater ACTH response to stress than age-matched controls (net peak of 9.0 pmol/L [41.0 pg/mL]; 95% confidence interval [CI], 4.7-13.3 pmol/L [21.6-60. 4 pg/mL]; vs net peak of 1.4 pmol/L [6.19 pg/mL]; 95% CI, 0.2-2.5 pmol/L [1.0-11.4 pg/mL]; difference, 8.6 pmol/L [38.9 pg/mL]; 95% CI, 4.6-12.6 pmol/L [20.8-57.1 pg/mL]; P<.001). More...
ACTH	Dinan, 2004	patients and normal controls	P-value=0.04	The mean +/- S.E.M. ACTH response in the depressives was 28....... The mean +/- S.E.M. ACTH response in the depressives was 28.4 +/- 4.3 ng/l and in the healthy subjects was 18.8 +/- 4.9 ng/l (P = 0.04). More...
ACTH	Posener, 2004	patients and normal controls		the depressed men had significantly increased cortisol ApEn ...... the depressed men had significantly increased cortisol ApEn (approximate entropy) and significantly decreased ACTH ApEn compared with the healthy subjects. More...
adrenocorticotropic hormone (ACTH)	Appelhof, 2006	patients only	P-value<0.05	Posttreatment maximal adrenocorticotropic hormone (ACTH) and...... Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). More...
ACTH	Ronsaville, 2006	high-risk people		offspring with early histories of mood problems, and those w...... offspring with early histories of mood problems, and those who developed major depressive disorder as young adults, did not exhibit basal hypercortisolism but did show an attenuated ACTH response to CRH. More...
adrenocorticotropin	Duval, 2006	patients and normal controls		Compared with controls, patients showed lower adrenocorticot...... Compared with controls, patients showed lower adrenocorticotropin and cortisol response to apomorphine (p<0.015 and <0.004, respectively) More...
corticotropin	Kennedy, 2006	patients and normal controls		Comparisons between patients with MDD and controls showed si...... Comparisons between patients with MDD and controls showed significantly lower neutral-state mu-opioid receptor BP in patients with MDD in the posterior thalamus, correlating with corticotropin and cortisol plasma levels. More...
ACTH	Ising, 2007	patients and normal controls		We found increased ACTH and cortisol responses to the first...... We found increased ACTH and cortisol responses to the first DEX/CRH test compared with healthy control subjects. More...
ACTH	Heim, 2008	patients and normal controls		Men with childhood trauma histories exhibited increases in A...... Men with childhood trauma histories exhibited increases in ACTH and cortisol responses to dexamethasone/CRF compared with non-abused men. In particular, abused men with current MDD showed increased responsiveness compared with control subjects and depressed men without childhood abuse experience More...
adrenocorticotropic hormone (ACTH)	Ahrens, 2008	patients and normal controls		This group(remitted patients from recurrent major depression...... This group(remitted patients from recurrent major depression) also displayed a blunted cortisol and ACTH response to the stressor, as compared with healthy controls. More...
corticotropin	Cizza, 2010	patients and normal controls		In cross-correlation analyses, the relationship between cort...... In cross-correlation analyses, the relationship between corticotropin and cortisol concentrations was stronger in women with MDD than in control subjects, a finding consistent with hypothalamic-pituitary-adrenal (HPA) axis activation in MDD. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
ACTH		rs1545843(rs1545843)	SNP	Schuhmacher A, 2013	patients and normal controls	P-value = 0.03	MDD patients carrying the depression-associated AA genotype ...... MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. More...
adrenocorticotropin		ADRA2A(ADRA2A)	gene	Haefner S, 2008	patients only	F = 4.9, d.f. = 2, p = 0.009	Male ADRA2A -1291G allele homozygotes showed significant pre...... Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). More...
adrenocorticotropin		ADRB2(ADRB2)	gene	Haefner S, 2008	patients only	F = 7.17, d.f. = 2, p = 0.001	female ADRB2 Arg/Arg homozygotes had increased pretreatment...... female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. More...
ACTH		Tumor necrosis factor(tumor necrosis factor (TNF)-alpha)	protein	Schuld, 2003	patients only		Baseline TNF-alpha levels were negatively correlated with th...... Baseline TNF-alpha levels were negatively correlated with the amount of ACTH released upon CRH stimulation during the DEX/CRH test. More...
ACTH		Rapid eye movement (REM) sleep(rapid eye movement (REM) sleep)	neurobiological system	Friess, 2008	patients and normal controls		We also observed an inverse association between the ACTH res...... We also observed an inverse association between the ACTH response to the Dex/CRH-test and rapid eye movement sleep (REM) density in HRPs, with suggestive evidence also in patients, but not in controls More...
ACTH		Depressed mood(melancholic)	symptoms	Kaestner, 2005	patients and normal controls		ACTH and cortisol concentrations were significantly elevated...... ACTH and cortisol concentrations were significantly elevated on admission in the melancholic but not the non-melancholic subgroup. More...
adrenocorticotropin hormone (ACTH)		Psychotic symptoms(psychotic depression)	symptoms	Owashi, 2008	patients only		The psychotic depression group exhibited greater elevation o...... The psychotic depression group exhibited greater elevation of ACTH responses to the DEX/CRH test than the non-psychotic depression group at admission. More...
adrenocorticotrophic hormone (ACTH)		Depressed mood(depression)	symptoms	Marcus, 2011	normal people		Infants born to women of the high/increasing depression grou...... Infants born to women of the high/increasing depression group had significant ACTH elevation at birth. More...
adrenocorticotropin hormone (ACTH)		Stress(stressful life events)	environment	Hikichi, 2007	patients only		SLEs(stressful life events) were significantly negatively as...... SLEs(stressful life events) were significantly negatively associated with DeltaMAX ACTH, ACTH AUC at the time of admission. More...
adrenocorticotropin hormone (ACTH)		Child abuse(childhood maltreatment)	environment	Carpenter, 2007	normal people		Compared with CTLs(without childhood maltreatment), MAL(chil...... Compared with CTLs(without childhood maltreatment), MAL(childhood maltreatment) subjects exhibited significantly lower cortisol and ACTH baseline-to-peak deltas. More...
ACTH		Child abuse(childhood trauma)	environment	Heim, 2008	patients and normal controls		Men with childhood trauma histories exhibited increases in A...... Men with childhood trauma histories exhibited increases in ACTH and cortisol responses to dexamethasone/CRF compared with non-abused men. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
POMC	proopiomelanocortin	Protein mapped	0 (0/0)