SNP Report

Name	rs1545843 dbSNP Ensembl
Location	Chrchr12:84564068(Forward)
Variant Alleles	G/A
Ancestral Allele	G
No. of Studies (Positive/Negative)	2 (2/0)

Reference	Research Type	Statistical Result	Relation Description
Kohli MA, 2011	Patients and nomal controls; animal model	p = 5.53e-08; OR = 2.84 [95% CI1.92¨C4.21])	The commonSNP rs1545843 (MAF = 0.41 in controls) on chr12q21...... The commonSNP rs1545843 (MAF = 0.41 in controls) on chr12q21.31 showedexperiment-wide signi?cance in a recessive mode of inheritance(AA versus AG+GG) after pplying the permutation-based minimum p method for multiple comparison correction over all tested SNPs and genetic models More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
rs1545843		SLC6A15(SLC6A15)	gene	Kohli MA, 2011	Patients and nomal controls; animal model	p = 0.00043	The MD risk genotype (AA) is associated with reduced full-le...... The MD risk genotype (AA) is associated with reduced full-length SLC6A15 mRNA expression levels compared to the nonrisk genotypes (AG+GG). More...
rs1545843		Pro-opiomelanocortin(ACTH)	protein	Schuhmacher A, 2013	patients and normal controls	P-value = 0.03	MDD patients carrying the depression-associated AA genotype ...... MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. More...
rs1545843		Hippocampus(hippocampal volumes)	brain morphology and function	Kohli MA, 2011	patients and normal controls	bilateral hippocampal volume (F>15.128, p<1.2e-04, N=204); left group: case- control, genotypes AA vs. AG/GG: F=5.861, P-value = 0.016, right: F=5.686, P-value = 0.018.	We confirmed bilateral hippocampal volume reductions in recu...... We confirmed bilateral hippocampal volume reductions in recurrent depression (F>15.128, p<1.2e-04, N=204) and found a rs1545843 genotype diagnosis interaction effect on both left and right total hippocampal volumes¡£ More...
rs1545843		Memory(memory)	cognition and behavior	Schuhmacher A, 2013	patients and normal controls	P-value = 0.04	MDD patients carrying the depression-associated AA genotype ...... MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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