Down regulation, fold change([MD] vs [C]) 2.1041868
Down regulation, fold change([MD] vs [C]) 2.1041868
Positive relationships between SLC6A15 and other components at different levels (count: 1)
Genetic/epigenetic locus
Protein and other molecule
Cell and molecular pathway
Neural system
Cognition and behavior
Symptoms and signs
Environment
Positive relationship network of SLC6A15 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus
Protein and Other Molecule
Cell and Molecular Pathway
Neural System
Cognition and Behavior
Symptoms and Signs
Environment
MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network.
If the mapped gene or protein is not from literature, square node would be used instead of Circle node.
Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between SLC6A15 and MDD (count: 0)
Negative relationships between SLC6A15 and other components at different levels (count: 0)
Eight SLC gene families are involved in the transport of ami......
Eight SLC gene families are involved in the transport of amino acids and oligopeptides.More...
Teleologically, one might argue that inorganic cation and an......
Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides.More...
This group of reactions is responsible for: 1) the breakdown......
This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine.More...
Hexoses like glucose, galactose and fructose serve as basic ......
Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins. SLC2 family contains 14 genes and encode facilitative glucose transporters. SLC5 family contains 12 genes and encode Na+/glucose symporters. SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers. SLC45 family has 4 members and encode putative sugar/H+ symporters.More...
The SLC6 gene family encodes proteins that mediate neurotran......
The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA.More...
Amino acid transport across plasma membranes is critical to ......
Amino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in which they are required for the synthesis of proteins and of amino acid derived small molecules such as neurotransmitters. Physiological studies have defined 18 systems that mediate amino acid transport, each characterized by its amino acid substrates, as well as its pH sensitivity and its association.More...
Proteins with transporting functions can be roughly classifi......
Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily.More...
SLC6A15 related interactors from protein-protein interaction data in HPRD (count: 0)