Gene Report

Basic Information

Approved Symbol	SLC6A15
Approved Name	solute carrier family 6 (neutral amino acid transporter), member 15
Previous Name	solute carrier family 6 (neurotransmitter transporter), member 15
Symbol Alias	hv7-3, NTT73, FLJ10316, V7-3, SBAT1
Name Alias	homolog of rat orphan transporter v7-3, "sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7"
Location	12q21.3
Position	chr12:85253267-85306608 (-)
External Links	Entrez Gene: 55117 Ensembl: ENSG00000072041 UCSC: uc001szv.3 HGNC ID: 13621
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between SLC6A15 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC6A15	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 2.1041868 Down regulation, fold change([MD] vs [C]) 2.1041868

Positive relationships between SLC6A15 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
SLC6A15		rs1545843(rs1545843)	SNP	Kohli MA, 2011	Patients and nomal controls; animal model	p = 0.00043	The MD risk genotype (AA) is associated with reduced full-le...... The MD risk genotype (AA) is associated with reduced full-length SLC6A15 mRNA expression levels compared to the nonrisk genotypes (AG+GG). More...

Positive relationship network of SLC6A15 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC6A15 and MDD (count: 0)

Negative relationships between SLC6A15 and other components at different levels (count: 0)

SLC6A15 related SNPs in MK4MDD (count: 0)

SLC6A15 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Sodium-dependent neutral amino acid transporter B(0)AT2	Q9H2J7	0(0/0)	Gene mapped

SLC6A15 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005326	neurotransmitter transporter activity	molecular function	NAS[11112352]
GO:0055085	transmembrane transport	biological process	TAS
GO:0005328	neurotransmitter:sodium symporter activity	molecular function	IEA
GO:0015820	leucine transport	biological process	ISS
GO:0006811	ion transport	biological process	TAS
GO:0005887	integral to plasma membrane	cellular component	IEA
GO:0006836	neurotransmitter transport	biological process	NAS[11112352]
GO:0016021	integral to membrane	cellular component	NAS[11112352]
GO:0015804	neutral amino acid transport	biological process	IDA[16226721]
GO:0006865	amino acid transport	biological process	TAS
GO:0005298	proline:sodium symporter activity	molecular function	IEA
GO:0015824	proline transport	biological process	ISS
GO:0005886	plasma membrane	cellular component	TAS

SLC6A15 related KEGG pathways (count: 0)

SLC6A15 related BioCarta pathways (count: 0)

SLC6A15 related Reactome pathways (count: 9)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_13	metabolism of_amino_acids	This group of reactions is responsible for: 1) the breakdown...... This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. More...
REACT_19305	glucose and_other_sugar_slc_transporters	Hexoses like glucose, galactose and fructose serve as basic ...... Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins. SLC2 family contains 14 genes and encode facilitative glucose transporters. SLC5 family contains 12 genes and encode Na+/glucose symporters. SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers. SLC45 family has 4 members and encode putative sugar/H+ symporters. More...
REACT_20506	na cl_dependent_neurotransmitter_transporters	The SLC6 gene family encodes proteins that mediate neurotran...... The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA. More...
REACT_20679	amine compound_slc_transporters	Five SLC gene families encode proteins that mediate transpor...... Five SLC gene families encode proteins that mediate transport of amines. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_13796	amino acid_transport_across_the_plasma_membrane	Amino acid transport across plasma membranes is critical to ...... Amino acid transport across plasma membranes is critical to the uptake of these molecules from the gut, to their reabsortion in the kidney proximal tubulues, and to their distribution to cells in which they are required for the synthesis of proteins and of amino acid derived small molecules such as neurotransmitters. Physiological studies have defined 18 systems that mediate amino acid transport, each characterized by its amino acid substrates, as well as its pH sensitivity and its association. More...
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...

SLC6A15 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways