Reactome Pathway Report
Basic Information
| ID |
|
| Name |
inorganic cation_anion_slc_transporters
|
| Description |
Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides.
|
REACT_19397 related genes in MK4MDD (count: 11)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| SLC3A2 |
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 |
Protein mapped
|
0(0/0) |
| SLC32A1 |
solute carrier family 32 (GABA vesicular transporter), member 1 |
Literature-origin; Protein mapped
|
1(1/0) |
| SLC1A2 |
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
Literature-origin; Protein mapped
|
3(3/0) |
| SLC17A7 |
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 |
Literature-origin; Protein mapped
|
4(4/0) |
| SLC6A15 |
solute carrier family 6 (neutral amino acid transporter), member 15 |
Literature-origin
|
2(2/0) |
| SLC1A6 |
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
Protein mapped
|
0(0/0) |
| SLC1A4 |
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
Protein mapped
|
0(0/0) |
| SLC17A6 |
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 |
Literature-origin
|
1(1/0) |
| SLC4A2 |
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) |
Literature-origin
|
1(1/0) |
| SLC4A4 |
solute carrier family 4, sodium bicarbonate cotransporter, member 4 |
Literature-origin
|
1(1/0) |
| SLC1A3 |
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
Literature-origin; Protein mapped
|
3(3/0) |
