Gene Report

Basic Information

Approved Symbol	SLC17A6
Approved Name	solute carrier family 17 (vesicular glutamate transporter), member 6
Previous Name	"solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6"
Symbol Alias	DNPI, VGLUT2
Name Alias	"vesicular glutamate transporter 2", "differentiation-associated Na-dependent inorganic phosphate cotransporter"
Location	11p14.3
Position	chr11:22399287-22401049 (+)
External Links	Entrez Gene: 57084 Ensembl: ENSG00000091664 UCSC: uc001mqk.3 HGNC ID: 16703
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SLC17A6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
VGLUT2	Uezato, 2009	patients and normal controls		We found decreased VGLUT1 mRNA expression in both MDD and BD...... We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus More...

Positive relationships between SLC17A6 and other components at different levels (count: 0)

Positive relationship network of SLC17A6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC17A6 and MDD (count: 0)

Negative relationships between SLC17A6 and other components at different levels (count: 0)

SLC17A6 related SNPs in MK4MDD (count: 0)

SLC17A6 related proteins in MK4MDD (count: 0)

SLC17A6 related GO terms (count: 11)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0055085	transmembrane transport	biological process	TAS
GO:0006836	neurotransmitter transport	biological process	IEA
GO:0015293	symporter activity	molecular function	IEA
GO:0006811	ion transport	biological process	TAS
GO:0089711	L-glutamate transmembrane transport	biological process	IBA
GO:0030672	synaptic vesicle membrane	cellular component	IBA; TAS
GO:0005313	L-glutamate transmembrane transporter activity	molecular function	IBA
GO:0006814	sodium ion transport	biological process	IEA
GO:0043005	neuron projection	cellular component	IEA
GO:0016021	integral component of membrane	cellular component	IBA

SLC17A6 related KEGG pathways (count: 0)

SLC17A6 related BioCarta pathways (count: 0)

SLC17A6 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...

SLC17A6 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways